Diabetes-specific enteral nutrition formula in hyperglycemic, mechanically ventilated, critically ill patients: A prospective, open-label, blind-randomized, multicenter study

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Mesejo, Alfonso ^a   Montejo González, Juan Carlos ^b   Vaquerizo Alonso, Clara ^c   Lobo Tamer, Gabriela ^d   Zabarte Martinez, Mercedes ^e   Herrero Meseguer, Jose Ignacio ^f   Acosta Escribano, Jose ^g   Blesa Malpica, Antonio ^h   Martinez Lozano, Fátima ⁱ  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL UNIVERSITARIO DE FUENLABRADA   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^e HOSPITAL DONOSTIA   (Spain)

^f HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^g HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^h HOSPITAL CLÍNICO SAN CARLOS   (Spain)

ⁱ HOSPITAL GENERAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; DOCOSAHEXAENOIC ACID; GLUCOSE; ICOSAPENTAENOIC ACID; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; GLUCOSE BLOOD LEVEL; INSULIN;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CALORIC INTAKE; CAPILLARY BLOOD; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIABETES MELLITUS; ENTERIC FEEDING; FEMALE; FIBER; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; INFECTION CONTROL; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; MORTALITY; MULTICENTER STUDY; OPEN STUDY; OUTCOME ASSESSMENT; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; TRACHEOBRONCHITIS; ANALYSIS; CRITICAL ILLNESS; DIET THERAPY; DRUG EFFECTS; GLYCEMIC INDEX; MIDDLE AGED; NURSING; NUTRITIONAL STATUS; PROCEDURES;

ADULT; AGED; BLOOD GLUCOSE; CRITICAL ILLNESS; DIABETES MELLITUS; ENTERAL NUTRITION; FEMALE; GLYCEMIC INDEX; HUMANS; HYPERGLYCEMIA; INSULIN; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PROSPECTIVE STUDIES;

EID: 84946547315     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-1108-1     Document Type: Article

References (43)

1. Mizock BA. Alterations in carbohydrate metabolism during stress: a review of the literature. Am J Med. 1995;98:75-84.
2. Mechanick JI. Metabolic mechanisms of stress hyperglycemia. J Parenter Enteral Nutr. 2006;30:157-63.
3. Finney SJ. Glucose control and mortality in critically ill patients. JAMA. 2003;290:2041-7.
4. Krinsley JC. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc. 2003;78:1471-8.
5. Corstjens AM, van der Horst IC, Zijlstra JG, Groeneveld AB, Zijlstra F, Tulleken JE, et al. Hyperglycaemia in critically ill patients: marker or mediator of mortality? Crit Care. 2006;10:R216.
6. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. EPIC II Group of Investigators International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302:2323-9.
7. Freire AX, Bridges L, Umpierrez GE, Kuhl D, Kitabchi AE. Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population. Chest. 2005;128:3109-16.
8. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology. 2006;105:244-52.
9. Hermanides J, Vriesendorp TM, Bosman RJ, Zandstra DF, Hoekstra JB, Devries JH. Glucose variability is associated with intensive care unit mortality. Crit Care Med. 2010;38:838-42.
10. Krinsley JS, Egi M, Kiss A, Devendra AN, Schuetz P, Maurer PM, et al. Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study. Crit Care. 2013;17:R37.
11. Donati A, Damiani E, Domizi R, Botticelli L, Castagnani R, Gabbanelli V, et al. Glycaemic variability, infections and mortality in a medical-surgical intensive care unit. Crit Care Resusc. 2014;16:13-23.
12. Alish CJ, Garvey WT, Maki KC, Sacks GS, Hustead DS, Hegazi RA, et al. A diabetes-specific enteral formula improves glycemic variability in patients with type 2 diabetes. Diabetes Technol Therap. 2010;12:419-25.
13. Bagshaw SM, Bellomo R, Jacka MJ, Egi M, Hart GK, George C. The impact of early hypoglycemia and blood glucose variability on outcome in critical illness. Crit Care. 2009;13:R91.
14. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283-97.
15. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010;137:544-51.
16. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359-67.
17. Pittas AG, Siegel RD, Lau J. Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized controlled trials. Arch Intern Med. 2004;164:2005-11.
18. Wiener RS, Wiener DC, Larson RJ. Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA. 2008;3008:933-44.
19. Ichai C, Preiser JC, for the Société Française d'Anesthésie-Réanimation (SFAR), Société de Réanimation de langue Française (SRLF) and the Experts group. International recommendations for glucose control in adult non diabetic critically ill patients. Crit Care. 2010;14:R 166.
20. Griesdale D, de Souza RJ, van Dam RB, Heyland D, Cook D, Malhotra A, et al. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ. 2009;180:821-7.
21. Vaquerizo Alonso C, Grau Carmona T, Juan Díaz M. Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus SEMICYUC-SENPE: hyperglycemia and diabetes mellitus. Nutr Hosp. 2011;26 Suppl 2:46-9.
22. Elia M, Ceriello A, Laube H, Sinclair AJ, Engfer M, Stratton RJ. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: a systematic review and meta-analysis. Diabetes Care. 2005;28:2267-79.
23. McMahon MM, Nystrom E, Braunschweig C, Miles J, Compher CH. A.S.P.E.N. Clinical guidelines: nutrition support of adult patients with hyperglycemia. J Parenter Enteral Nutr. 2013;37:23-36.
24. Canadian clinical practice guidelines. 2013. Available at http://www.criticalcarenutrition.com. Accessed 30 September 2014.
25. Pohl M, Mayr P, Mertl-Roetzer M, Lauster F, Lerch M, Eriksen J, et al. Glycaemic control in type II diabetic tube-fed patients with a new enteral formula low in carbohydrates and high in monounsaturated fatty acids: a randomised controlled trial. Eur J Clin Nutr. 2005;59:1221-32.
26. Voss AC, Maki KC, Garvey WT, Hustead DS, Alish C, Fix B, et al. Effect of two carbohydrate-modified tube-feeding formulas on metabolic responses in patients with type 2 diabetes. Nutrition. 2008;24:990-7.
27. Leon-Sanz M, Garcia-Luna PP, Sanz-Paris A, Gomez-Candela C, Casimiro C, Chamorro J, et al. Glycemic and lipid control in hospitalized type 2 diabetic patients: evaluation of 2 enteral nutrition formulas (low carbohydrate-high monounsaturated fat vs high carbohydrate). J Parenter Enteral Nutr. 2005;29:21-9.
28. Crespillo MC, Olveira G, de Adana MS R, Rojo-Martinez G, Garcia-Aleman J, Olvera P, et al. Metabolic effects of an enteral nutrition formula for diabetes: comparison with standard formulas in patients with type 1 diabetes. Clin Nutr. 2003;22:483-7.
29. Vaisman N, Lansink M, Rouws CH, van Laere KM, Segal R, Niv E, et al. Tube feeding with a diabetes-specific feed for 12 weeks improves glycaemic control in type 2 diabetes patients. Clin Nutr. 2009;28:549-55.
30. Mesejo A, Acosta JA, Ortega C, Vila J, Fernández M, Ferreres J, et al. Comparison of a high-protein disease-specific enteral formula with a high-protein enteral formula in hyperglycemic critically ill patients. Clin Nutr. 2003;22:295-305.
31. Standards of medical care in diabetes. American Diabetes Association. Diabetes Care. 2013;36 Supp 1:S11-66.
32. Valencia E, Marin A, Hardy G. Nutrition therapy for acute renal failure: a new approach based on 'risk, injury, failure, loss, and end-stage kidney' classification (RIFLE). Curr Opin Clin Nutr Metab Care. 2009;12:241-4.
33. HOMA calculator. Available at http://www.dtu.ox.ac.uk/homacalculator/index.php. Accessed 30 September 2014.
34. Ryan EA, Shandro T, Green K, Paty BW, Senior PA, Bigam D, et al. Assessment of the severity of hypoglycemia and glycemic lability in Type 1 diabetic subjects undergoing islet transplantation. Diabetes. 2004;53:955-62.
35. Montejo JC. Enteral nutrition-related gastrointestinal complications in critically ill patients: a multicenter study. The Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units. Crit Care Med. 1999;27:1447-53.
36. Montejo JC, Miñambres E, Bordejé L, Mesejo A, Acosta J, Heras A, et al. Gastric residual volume during enteral nutrition in ICU patients: the REGANE study. Intensive Care Med. 2010;36:1386-93.
37. Calandra T, Cohen J. The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med. 2005;33:1538-48.
38. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36:309-32.
39. Bochicchio GV, Bochicchio KM, Joshi M, Ilahi O, Scalea TM. Acute glucose elevation is highly predictive of infection and outcome in critically injured trauma patients. Ann Surg. 2010;252:597-602.
40. Hanazaki K, Maeda H, Okabayashi T. Relationship between perioperative glycemic control and postoperative infections. World J Gastroenterol. 2009;15:4122-5.
41. Hemmila MR, Taddonio MA, Arbabi S, Maggio PM, Wahl WL. Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery. 2008;144:629-37.
42. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters P, Milants I, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449-61.
43. Finfer S, Wernerman J, Preiser JCH, Cass T, Desaive T, Hovorka R, et al. Clinical review: consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults. Crit Care. 2013;17:R 229.