AT-1001 Is a partial agonist with high affinity and selectivity at human and rat α3β4 nicotinic cholinergic receptors

Molecular Pharmacology

Volumn 88, Issue 4, 2015, Pages 640-649

  Tuan, Edward W ^a   Horti, Andrew G ^b   Olson, Thao T ^a   Gao, Yongiun ^b   Stockmeier, Craig A ^c   Al Muhtasib, Nour ^a   Dalley, Carrie Bowman ^a   Lewin, Amanda E ^a   Wolfe, Barry B ^a   Sahibzada, Niaz ^a   Xiao, Yingxian ^a   Kellar, Kenneth J ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA3BETA4 NICOTINIC CHOLINERGIC RECEPTOR; LARAZOTIDE; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG; AT-1001; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA3BETA4; OLIGOPEPTIDE; PROTEIN BINDING;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PARTIAL AGONISM; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; ANIMAL; DOSE RESPONSE; FEMALE; HEK293 CELL LINE; MALE; METABOLISM; PHYSIOLOGY; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG PARTIAL AGONISM; FEMALE; HEK293 CELLS; HUMANS; MALE; NICOTINIC AGONISTS; OLIGOPEPTIDES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SPECIES SPECIFICITY;

EID: 84946546387     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.115.099978     Document Type: Article

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