[125I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors

Neuropharmacology

Volumn 77, Issue , 2014, Pages 193-199

  Wu, Jinhua ^a   Perry, David C ^b   Bupp, James E ^c   Jiang, Faming ^d   Polgar, Willma E ^c   Toll, Lawrence ^a   Zaveri, Nurulain T ^d  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c SRI INTERNATIONAL   (United States)

^d Astraea Therapeutics Inc   (Spain)

Author keywords

Alpha3beta4; AT 1012; In vitro autoradiography; Nicotinic acetylcholine receptor; Receptor binding

Indexed keywords

18 METHOXYCORONARIDINE; AT 1012; AT 1012 I 125; EPIBATIDINE; EPIBATIDINE H 3; LARAZOTIDE; MECAMYLAMINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA3BETAALPHA5; NICOTINIC RECEPTOR ALPHA4BETA2; RADIOLIGAND; UNCLASSIFIED DRUG; LIGAND;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; BRAIN SLICE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EMBRYO; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; ALPHA3BETA4; ANIMAL; AT-1012; CHEMISTRY; HEK293 CELL LINE; IN VITRO AUTORADIOGRAPHY; METABOLISM; PROTEIN BINDING; RADIOASSAY; RECEPTOR BINDING; SPRAGUE DAWLEY RAT;

ALPHA3BETA4; AT-1012; IN VITRO AUTORADIOGRAPHY; NICOTINIC ACETYLCHOLINE RECEPTOR; RECEPTOR BINDING;

ANIMALS; AUTORADIOGRAPHY; FEMALE; HEK293 CELLS; HUMANS; LIGANDS; MALE; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC;

EID: 84886259723     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.09.023     Document Type: Article

References (32)

1. C.G. Baddick, and M.J. Marks An autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutants Biochem. Pharmacol. 82 8 2011 828 841
2. B. Badio, and J.W. Daly Epibatidine, a potent analgetic and nicotinic agonist Mol. Pharmacol. 45 4 1994 563 569 (Pubitemid 24139181)
3. W. Berrettini, X. Yuan, F. Tozzi, K. Song, C. Francks, H. Chilcoat, D. Waterworth, P. Muglia, and V. Mooser Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking Mol. Psychiatry 13 4 2008 368 373 (Pubitemid 351399826)
4. Y. Cheng, and W.H. Prusoff Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Biochem. Pharmacol. 22 23 1973 3099 3108
5. 125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors J. Pharmacol. Exp. Ther. 282 1 1997 445 451 (Pubitemid 27425573)
6. V. Gerzanich, X. Peng, F. Wang, G. Wells, R. Anand, S. Fletcher, and J. Lindstrom Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors Mol. Pharmacol. 48 4 1995 774 782
7. S.D. Glick, and I.M. Maisonneuve Development of novel medications for drug addiction. The legacy of an African shrub Ann. N. Y. Acad. Sci. 909 2000 88 103 (Pubitemid 30462034)
8. S.D. Glick, I.M. Maisonneuve, and H.A. Dickinson 18-MC reduces methamphetamine and nicotine self-administration in rats Neuroreport 11 9 2000 2013 2015 (Pubitemid 30429154)
9. S.D. Glick, I.M. Maisonneuve, and B.A. Kitchen Modulation of nicotine self-administration in rats by combination therapy with agents blocking alpha 3 beta 4 nicotinic receptors Eur. J. Pharmacol. 448 2-3 2002 185 191 (Pubitemid 34874586)
10. S.D. Glick, I.M. Maisonneuve, and K.K. Szumlinski 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action Ann. N. Y. Acad. Sci. 914 2000 369 386
11. S.D. Glick, R.L. Ramirez, J.M. Livi, and I.M. Maisonneuve 18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats Eur. J. Pharmacol. 537 1-3 2006 94 98
12. C. Gotti, F. Clementi, A. Fornari, A. Gaimarri, S. Guiducci, I. Manfredi, M. Moretti, P. Pedrazzi, L. Pucci, and M. Zoli Structural and functional diversity of native brain neuronal nicotinic receptors Biochem. Pharmacol. 78 7 2009 703 711
13. C. Gotti, D. Fornasari, and F. Clementi Human neuronal nicotinic receptors Prog. Neurobiol. 53 2 1997 199 237 (Pubitemid 27436001)
14. S.R. Grady, N.M. Meinerz, J. Cao, A.M. Reynolds, M.R. Picciotto, J.P. Changeux, J.M. McIntosh, M.J. Marks, and A.C. Collins Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum J. Neurochem. 76 1 2001 258 268 (Pubitemid 32044388)
15. S.R. Grady, M. Moretti, M. Zoli, M.J. Marks, A. Zanardi, L. Pucci, F. Clementi, and C. Gotti Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release J. Neurosci. 29 7 2009 2272 2282
16. 3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain Mol. Pharmacol. 48 2 1995 280 287
17. 125I analog of a highly selective alpha3beta4 nicotinic acetylcholine receptor antagonist ligand for use in autoradiography studies J. Labelled Comp. Radiopharm. 55 5 2012 177 179
18. S. Luo, J.M. Kulak, G.E. Cartier, R.B. Jacobsen, D. Yoshikami, B.M. Olivera, and J.M. McIntosh alpha-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release J. Neurosci. 18 21 1998 8571 8579 (Pubitemid 28491724)
19. I.M. Maisonneuve, and S.D. Glick Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment Pharmacol. Biochem. Behav. 75 3 2003 607 618 (Pubitemid 36936895)
20. M.J. Marks, and A.C. Collins Characterization of nicotine binding in mouse brain and comparison with the binding of alpha-bungarotoxin and quinuclidinyl benzilate Mol. Pharmacol. 22 3 1982 554 564 (Pubitemid 13201811)
21. M.J. Marks, P. Whiteaker, S.R. Grady, M.R. Picciotto, J.M. McIntosh, and A.C. Collins Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice J. Neurochem. 81 5 2002 1102 1115 (Pubitemid 34809293)
22. S.E. McCallum, M.A. Cowe, S.W. Lewis, and S.D. Glick alpha3beta4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo Neuropharmacology 63 3 2012 434 440
23. S.E. McCallum, and S.D. Glick 18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference Neurosci. Lett. 458 2 2009 57 59
24. D.S. McGehee, M.J. Heath, S. Gelber, P. Devay, and L.W. Role Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors Science 269 5231 1995 1692 1696
25. 3H]cytisine binding to nicotinic cholinergic receptors in brain Mol. Pharmacol. 39 1 1991 9 12
26. D.C. Perry, Y. Xiao, H.N. Nguyen, J.L. Musachio, M.I. Davila-Garcia, and K.J. Kellar Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography J. Neurochem. 82 3 2002 468 481 (Pubitemid 34831488)
27. A.H. Rezvani, D.H. Overstreet, Y. Yang, I.M. Maisonneuve, U.K. Bandarage, M.E. Kuehne, and S.D. Glick Attenuation of alcohol consumption by a novel nontoxic ibogaine analogue (18-methoxycoronaridine) in alcohol-preferring rats Pharmacol. Biochem. Behav. 58 2 1997 615 619 (Pubitemid 27394320)
28. C. Romano, and A. Goldstein Stereospecific nicotine receptors on rat brain membranes Science 210 4470 1980 647 650 (Pubitemid 11220278)
29. S.F. Saccone, N.L. Saccone, G.E. Swan, P.A. Madden, A.M. Goate, J.P. Rice, and L.J. Bierut Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence Bioinformatics 24 16 2008 1805 1811
30. R. Salas, F. Pieri, and M. De Biasi Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit J. Neurosci. 24 45 2004 10035 10039 (Pubitemid 39492026)
31. L. Toll, N.T. Zaveri, W.E. Polgar, F. Jiang, T.V. Khroyan, W. Zhou, X.S. Xie, G.B. Stauber, M.R. Costello, and F.M. Leslie AT-1001: a high affinity and selective alpha3beta4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats Neuropsychopharmacology 37 6 2012 1367 1376
32. Y. Xiao, and K.J. Kellar The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells J. Pharmacol. Exp. Ther. 310 1 2004 98 107 (Pubitemid 38812700)