Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing

EMBO Journal

Volumn 34, Issue 21, 2015, Pages 2686-2702

  Jung, Sangyong ^a,b,c   Maritzen, Tanja ^d,e   Wichmann, Carolin ^a,b   Jing, Zhizi ^a,b   Neef, Andreas ^f   Revelo, Natalia H ^a,b   Al Moyed, Hanan ^a,b   Meese, Sandra ^b   Wojcik, Sonja M ^g   Panou, Iliana ^a,b   Bulut, Haydar ^d   Schu, Peter ^a   Ficner, Ralf ^b   Reisinger, Ellen ^a,b   Rizzoli, Silvio O ^a,b   Neef, Jakob ^a,b,c   Strenzke, Nicola ^a,b   Haucke, Volker ^d,e   Moser, Tobias ^a,b,c  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

^f MAX PLANCK INSTITUTE FOR DYNAMICS AND SELF ORGANIZATION   (Germany)

^g MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

active zone; endocytosis; release site clearance; synaptic ribbon; vesicle reformation

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN 2MU; CLATHRIN; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 3; ENDOCYTIC ADAPTOR PROTEIN 2MU, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; EXOCYTOSIS; HEARING IMPAIRMENT; INNER HAIR CELL; MOUSE; NONHUMAN; OUTER HAIR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; COCHLEAR HAIR CELL; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING; METABOLISM; PHYSIOLOGY; SYNAPSE; TRANSGENIC MOUSE;

ACTION POTENTIALS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HAIR CELLS, AUDITORY; HEARING; MICE, INBRED C57BL; MICE, TRANSGENIC; SYNAPSES; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

EID: 84946500434     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201591885     Document Type: Article

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