Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 24, 2015, Pages E3141-E3149

  Jung, Sangyong ^a,b   Oshima Takago, Tomoko ^a,b   Chakrabarti, Rituparna ^a,b   Wong, Aaron B ^a,b,g   Jing, Zhizi ^a,b   Yamanbaeva, Gulnara ^a,b   Picher, Maria Magdalena ^b,c   Wojcik, Sonja M ^d   Göttfert, Fabian ^b,e   Predoehl, Friederike ^a   Michel, Katrin ^f   Hell, Stefan W ^b,e   Schoch, Susanne ^f   Strenzke, Nicola ^a,b   Wichmann, Carolin ^a,b   Moser, Tobias ^a,b,c  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c BERNSTEIN CENTER FOR COMPUTATIONAL NEUROSCIENCE   (Germany)

^d MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^e MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^f UNIVERSITY OF BONN   (Germany)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Active zone; Ca2+ channel; Rab3 interacting molecule; Ribbon synapse; Vesicle

Indexed keywords

AMPA RECEPTOR; CALCIUM CHANNEL CAV1.3; CRE RECOMBINASE; MESSENGER RNA; RAB PROTEIN; RAB3 INTERACTING MOLECULE 2 ALPHA; RAB3 INTERACTING MOLECULE 2 BETA; RAB3 INTERACTING MOLECULE 2 GAMMA; SYNAPSIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; CACNA1D PROTEIN, MOUSE; CALCIUM CHANNEL L TYPE; RIM2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN STEM RESPONSE; CALCIUM TRANSPORT; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXOCYTOSIS; FLUCTUATION ANALYSIS; HAIR CELL; HEARING; HYPERBARISM; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; INNER HAIR CELL; MOUSE; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYNAPSE VESICLE; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CHANNEL GATING; DEFICIENCY; ELECTRON TOMOGRAPHY; EVOKED BRAIN STEM AUDITORY RESPONSE; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SPIRAL GANGLION; SPONTANEOUS OTOACOUSTIC EMISSION; SYNAPSE; ULTRASTRUCTURE;

MUS;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; ELECTRON MICROSCOPE TOMOGRAPHY; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; EXOCYTOSIS; HAIR CELLS, AUDITORY, INNER; HEARING; ION CHANNEL GATING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OTOACOUSTIC EMISSIONS, SPONTANEOUS; PATCH-CLAMP TECHNIQUES; RAB3 GTP-BINDING PROTEINS; SPIRAL GANGLION; SYNAPSES; SYNAPTIC VESICLES;

EID: 84935871875     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417207112     Document Type: Article

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