PH-cleavable nucleoside lipids: A new paradigm for controlling the stability of lipid-based delivery systems

ChemMedChem

Volumn 10, Issue 11, 2015, Pages 1797-1801

  Oumzil, Khalid ^a   Benizri, Sébastien ^a   Tonelli, Giovanni ^a   Staedel, Cathy ^a   Appavoo, Ananda ^a   Chaffanet, Max ^b,c   Navailles, Laurence ^d   Barthélémy, Philippe ^a  

^a INSERM U869   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

drug delivery; lipids; nucleosides; pH responsive; small interfering RNA (siRNA)

Indexed keywords

HEXADECANOL; LIPID; LIPOSOME; NANOPARTICLE; NUCLEOSIDE DERIVATIVE; ORTHOESTER NUCLEOSIDE LIPID; PHOSPHORYLCHOLINE; RECQ HELICASE; SMALL INTERFERING RNA; STABLE NUCLEIC ACID LIPID PARTICLE; UNCLASSIFIED DRUG; NUCLEOSIDE;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG RELEASE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; LIPOGENESIS; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; STRUCTURE ANALYSIS; CHEMISTRY; SYNTHESIS;

DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; LIPOSOMES; NUCLEOSIDES;

EID: 84946492272     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201500381     Document Type: Article

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