메뉴 건너뛰기




Volumn 58, Issue 12, 2015, Pages 2885-2898

Role of the renal sympathetic nerve in renal glucose metabolism during the development of type 2 diabetes in rats

Author keywords

Blood pressure; Glucose metabolism; Insulin resistance; Renal sympathetic denervation (RDX); Sglt2; Slc5a2; Sodium glucose cotransporter 2; Type 2 diabetes

Indexed keywords

GLUCOSE TRANSPORTER; NORADRENALIN; SODIUM GLUCOSE COTRANSPORTER 2; GLUCOSE;

EID: 84946491938     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3771-9     Document Type: Article
Times cited : (49)

References (58)
  • 1
    • 33750281024 scopus 로고    scopus 로고
    • Mechanisms of sympathetic activation in obesity-related hypertension
    • COI: 1:CAS:528:DC%2BD28XhtVKjtL3N
    • Esler M, Straznicky N, Eikelis N, Masuo K, Lambert G, Lambert E (2006) Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48:787–796
    • (2006) Hypertension , vol.48 , pp. 787-796
    • Esler, M.1    Straznicky, N.2    Eikelis, N.3    Masuo, K.4    Lambert, G.5    Lambert, E.6
  • 2
    • 77951091946 scopus 로고    scopus 로고
    • Sympathetic nervous activation in obesity and the metabolic syndrome—causes, consequences and therapeutic implications
    • COI: 1:CAS:528:DC%2BC3cXksF2qur4%3D
    • Lambert GW, Straznicky NE, Lambert EA, Dixon JB, Schlaich MP (2010) Sympathetic nervous activation in obesity and the metabolic syndrome—causes, consequences and therapeutic implications. Pharmacol Ther 126:159–172
    • (2010) Pharmacol Ther , vol.126 , pp. 159-172
    • Lambert, G.W.1    Straznicky, N.E.2    Lambert, E.A.3    Dixon, J.B.4    Schlaich, M.P.5
  • 3
    • 0030686447 scopus 로고    scopus 로고
    • Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity
    • COI: 1:CAS:528:DyaK2sXnvV2itb8%3D
    • Scherrer U, Sartori C (1997) Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 96:4104–4113
    • (1997) Circulation , vol.96 , pp. 4104-4113
    • Scherrer, U.1    Sartori, C.2
  • 4
    • 34147127615 scopus 로고    scopus 로고
    • The sympathetic nervous system and the metabolic syndrome
    • COI: 1:CAS:528:DC%2BD2sXjvFCls7c%3D
    • Mancia G, Bousquet P, Elghozi JL et al (2007) The sympathetic nervous system and the metabolic syndrome. J Hypertens 25:909–920
    • (2007) J Hypertens , vol.25 , pp. 909-920
    • Mancia, G.1    Bousquet, P.2    Elghozi, J.L.3
  • 5
    • 84922568041 scopus 로고    scopus 로고
    • Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation
    • Linz D, Hohl M, Schutze J et al (2015) Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation. Am J Hypertens 28:256–265
    • (2015) Am J Hypertens , vol.28 , pp. 256-265
    • Linz, D.1    Hohl, M.2    Schutze, J.3
  • 6
    • 23944448775 scopus 로고    scopus 로고
    • Physiology in perspective: the wisdom of the body. Neural control of the kidney
    • COI: 1:CAS:528:DC%2BD2MXhtVWktrrI
    • DiBona GF (2005) Physiology in perspective: the wisdom of the body. Neural control of the kidney. Am J Physiol Regul Integr Com Physiol 289:R633–R641
    • (2005) Am J Physiol Regul Integr Com Physiol , vol.289 , pp. 633-641
    • DiBona, G.F.1
  • 7
    • 75749150916 scopus 로고    scopus 로고
    • The 2009 Carl Ludwig lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management
    • COI: 1:CAS:528:DC%2BC3cXisVejt7g%3D
    • Esler M (2010) The 2009 Carl Ludwig lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management. J Appl Physiol (1985) 108:227–237
    • (2010) J Appl Physiol (1985) , vol.108 , pp. 227-237
    • Esler, M.1
  • 8
    • 0346788540 scopus 로고    scopus 로고
    • Impact of type 2 diabetes mellitus on sympathetic neural mechanisms in hypertension
    • COI: 1:CAS:528:DC%2BD3sXpvVSjt7s%3D
    • Huggett RJ, Scott EM, Gilbey SG, Stoker JB, Mackintosh AF, Mary DA (2003) Impact of type 2 diabetes mellitus on sympathetic neural mechanisms in hypertension. Circulation 108:3097–3101
    • (2003) Circulation , vol.108 , pp. 3097-3101
    • Huggett, R.J.1    Scott, E.M.2    Gilbey, S.G.3    Stoker, J.B.4    Mackintosh, A.F.5    Mary, D.A.6
  • 9
    • 0027184924 scopus 로고
    • Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans
    • COI: 1:CAS:528:DyaK3sXlsFOnt78%3D
    • Vollenweider P, Tappy L, Randin D et al (1993) Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. J Clin Invest 92:147–154
    • (1993) J Clin Invest , vol.92 , pp. 147-154
    • Vollenweider, P.1    Tappy, L.2    Randin, D.3
  • 10
    • 0022492202 scopus 로고
    • Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity
    • COI: 1:STN:280:DyaL287jsVSltQ%3D%3D
    • Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI (1986) Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 73:615–621
    • (1986) Circulation , vol.73 , pp. 615-621
    • Hasking, G.J.1    Esler, M.D.2    Jennings, G.L.3    Burton, D.4    Johns, J.A.5    Korner, P.I.6
  • 11
    • 84871312992 scopus 로고    scopus 로고
    • Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial
    • COI: 1:CAS:528:DC%2BC38XhvVCqsL3E
    • Esler MD, Krum H, Schlaich M, Schmieder RE, Bohm M, Sobotka PA (2012) Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 126:2976–2982
    • (2012) Circulation , vol.126 , pp. 2976-2982
    • Esler, M.D.1    Krum, H.2    Schlaich, M.3    Schmieder, R.E.4    Bohm, M.5    Sobotka, P.A.6
  • 12
    • 78649876825 scopus 로고    scopus 로고
    • Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    • Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376:1903–1909
    • (2010) Lancet , vol.376 , pp. 1903-1909
    • Esler, M.D.1    Krum, H.2    Sobotka, P.A.3    Schlaich, M.P.4    Schmieder, R.E.5    Bohm, M.6
  • 13
    • 64049084640 scopus 로고    scopus 로고
    • Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
    • Krum H, Schlaich M, Whitbourn R et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373:1275–1281
    • (2009) Lancet , vol.373 , pp. 1275-1281
    • Krum, H.1    Schlaich, M.2    Whitbourn, R.3
  • 14
    • 84857773847 scopus 로고    scopus 로고
    • Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension
    • Brandt MC, Mahfoud F, Reda S et al (2012) Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension. J Am Coll Cardiol 59:901–909
    • (2012) J Am Coll Cardiol , vol.59 , pp. 901-909
    • Brandt, M.C.1    Mahfoud, F.2    Reda, S.3
  • 15
    • 84858625891 scopus 로고    scopus 로고
    • Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation
    • COI: 1:CAS:528:DC%2BC38Xktlejsbg%3D
    • Rafiq K, Noma T, Fujisawa Y et al (2012) Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation. Circulation 125:1402–1413
    • (2012) Circulation , vol.125 , pp. 1402-1413
    • Rafiq, K.1    Noma, T.2    Fujisawa, Y.3
  • 16
    • 84898731305 scopus 로고    scopus 로고
    • A controlled trial of renal denervation for resistant hypertension
    • COI: 1:CAS:528:DC%2BC2cXmsVWrurg%3D
    • Bhatt DL, Kandzari DE, O'Neill WW et al (2014) A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370:1393–1401
    • (2014) N Engl J Med , vol.370 , pp. 1393-1401
    • Bhatt, D.L.1    Kandzari, D.E.2    O'Neill, W.W.3
  • 17
    • 79955755012 scopus 로고    scopus 로고
    • Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study
    • COI: 1:CAS:528:DC%2BC3MXlslynt74%3D
    • Mahfoud F, Schlaich M, Kindermann I et al (2011) Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study. Circulation 123:1940–1946
    • (2011) Circulation , vol.123 , pp. 1940-1946
    • Mahfoud, F.1    Schlaich, M.2    Kindermann, I.3
  • 18
    • 80053494865 scopus 로고    scopus 로고
    • Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea
    • COI: 1:CAS:528:DC%2BC3MXhtFGlsbbK
    • Witkowski A, Prejbisz A, Florczak E et al (2011) Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea. Hypertension 58:559–565
    • (2011) Hypertension , vol.58 , pp. 559-565
    • Witkowski, A.1    Prejbisz, A.2    Florczak, E.3
  • 19
    • 79954824358 scopus 로고    scopus 로고
    • Renal denervation: a potential new treatment modality for polycystic ovary syndrome?
    • COI: 1:CAS:528:DC%2BC3MXktl2gsb4%3D
    • Schlaich MP, Straznicky N, Grima M et al (2011) Renal denervation: a potential new treatment modality for polycystic ovary syndrome? J Hypertens 29:991–996
    • (2011) J Hypertens , vol.29 , pp. 991-996
    • Schlaich, M.P.1    Straznicky, N.2    Grima, M.3
  • 20
    • 0026722931 scopus 로고
    • Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain
    • COI: 1:STN:280:DyaK3s%2Fht1GitA%3D%3D
    • Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T (1992) Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41:1422–1428
    • (1992) Diabetes , vol.41 , pp. 1422-1428
    • Kawano, K.1    Hirashima, T.2    Mori, S.3    Saitoh, Y.4    Kurosumi, M.5    Natori, T.6
  • 21
    • 0031025367 scopus 로고    scopus 로고
    • Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats
    • COI: 1:CAS:528:DyaK2sXhvFSgsLo%3D
    • Yagi K, Kim S, Wanibuchi H, Yamashita T, Yamamura Y, Iwao H (1997) Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats. Hypertension 29:728–735
    • (1997) Hypertension , vol.29 , pp. 728-735
    • Yagi, K.1    Kim, S.2    Wanibuchi, H.3    Yamashita, T.4    Yamamura, Y.5    Iwao, H.6
  • 22
    • 0020376114 scopus 로고
    • Renorenal reflexes in the rat elicited upon stimulation of renal chemoreceptors
    • COI: 1:STN:280:DyaL3s%2FotlOlsg%3D%3D
    • Recordati G, Genovesi S, Cerati D (1982) Renorenal reflexes in the rat elicited upon stimulation of renal chemoreceptors. J Auton Nerv Syst 6:127–142
    • (1982) J Auton Nerv Syst , vol.6 , pp. 127-142
    • Recordati, G.1    Genovesi, S.2    Cerati, D.3
  • 24
    • 0029867022 scopus 로고    scopus 로고
    • Renal denervation prevents intraglomerular platelet aggregation and glomerular injury induced by chronic inhibition of nitric oxide synthesis
    • COI: 1:CAS:528:DyaK28Xjt12itL4%3D
    • Nakashima A, Matsuoka H, Yasukawa H et al (1996) Renal denervation prevents intraglomerular platelet aggregation and glomerular injury induced by chronic inhibition of nitric oxide synthesis. Nephron 73:34–40
    • (1996) Nephron , vol.73 , pp. 34-40
    • Nakashima, A.1    Matsuoka, H.2    Yasukawa, H.3
  • 25
    • 1042303652 scopus 로고    scopus 로고
    • Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats
    • Luippold G, Beilharz M, Muhlbauer B (2004) Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats. Nephrol Dial Transplant 19:342–347
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 342-347
    • Luippold, G.1    Beilharz, M.2    Muhlbauer, B.3
  • 26
    • 0035724736 scopus 로고    scopus 로고
    • Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats
    • COI: 1:CAS:528:DC%2BD3MXotVCgtrs%3D
    • Henriksen EJ, Jacob S, Kinnick TR, Teachey MK, Krekler M (2001) Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension 38:884–890
    • (2001) Hypertension , vol.38 , pp. 884-890
    • Henriksen, E.J.1    Jacob, S.2    Kinnick, T.R.3    Teachey, M.K.4    Krekler, M.5
  • 27
    • 80053114420 scopus 로고    scopus 로고
    • Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance
    • Rafiq K, Hitomi H, Nakano D, Ichihara A, Nishiyama A (2011) Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance. Front Biosci (Schol Ed) 3:1478–1485
    • (2011) Front Biosci (Schol Ed) , vol.3 , pp. 1478-1485
    • Rafiq, K.1    Hitomi, H.2    Nakano, D.3    Ichihara, A.4    Nishiyama, A.5
  • 28
    • 0020791161 scopus 로고
    • In vivo insulin sensitivity in the rat determined by euglycemic clamp
    • COI: 1:CAS:528:DyaL3sXkvValsLc%3D
    • Kraegen EW, James DE, Bennett SP, Chisholm DJ (1983) In vivo insulin sensitivity in the rat determined by euglycemic clamp. Am J Physiol 245:E1–E7
    • (1983) Am J Physiol , vol.245 , pp. 1-7
    • Kraegen, E.W.1    James, D.E.2    Bennett, S.P.3    Chisholm, D.J.4
  • 29
    • 0036899150 scopus 로고    scopus 로고
    • Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling
    • COI: 1:CAS:528:DC%2BD38XovFKnsLY%3D
    • Ogihara T, Asano T, Ando K et al (2002) Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension 40:872–879
    • (2002) Hypertension , vol.40 , pp. 872-879
    • Ogihara, T.1    Asano, T.2    Ando, K.3
  • 30
    • 84856701189 scopus 로고    scopus 로고
    • Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension
    • COI: 1:CAS:528:DC%2BC38Xnt1ylsw%3D%3D
    • Prysyazhna O, Rudyk O, Eaton P (2012) Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat Med 18:286–290
    • (2012) Nat Med , vol.18 , pp. 286-290
    • Prysyazhna, O.1    Rudyk, O.2    Eaton, P.3
  • 31
    • 0034651711 scopus 로고    scopus 로고
    • Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats
    • COI: 1:CAS:528:DC%2BD3cXhtlGntLY%3D
    • Zhang YC, Bui JD, Shen L, Phillips MI (2000) Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation 101:682–688
    • (2000) Circulation , vol.101 , pp. 682-688
    • Zhang, Y.C.1    Bui, J.D.2    Shen, L.3    Phillips, M.I.4
  • 32
    • 2342525336 scopus 로고    scopus 로고
    • Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice
    • COI: 1:CAS:528:DC%2BD2cXjt1Gmsbc%3D
    • Shiuchi T, Iwai M, Li HS et al (2004) Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. Hypertension 43:1003–1010
    • (2004) Hypertension , vol.43 , pp. 1003-1010
    • Shiuchi, T.1    Iwai, M.2    Li, H.S.3
  • 33
    • 0035105826 scopus 로고    scopus 로고
    • Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle
    • COI: 1:CAS:528:DC%2BD3MXhtFSrs7k%3D
    • Shiuchi T, Nakagami H, Iwai M et al (2001) Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle. Endocrinology 142:608–612
    • (2001) Endocrinology , vol.142 , pp. 608-612
    • Shiuchi, T.1    Nakagami, H.2    Iwai, M.3
  • 34
    • 0025942149 scopus 로고
    • Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats
    • COI: 1:CAS:528:DyaK3MXmtVCiur0%3D
    • Sudo M, Minokoshi Y, Shimazu T (1991) Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats. Am J Physiol 261:E298–E303
    • (1991) Am J Physiol , vol.261 , pp. 298-303
    • Sudo, M.1    Minokoshi, Y.2    Shimazu, T.3
  • 35
    • 78651317494 scopus 로고    scopus 로고
    • Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats
    • COI: 1:CAS:528:DC%2BC3cXhs1aks7vN
    • Rafiq K, Nakano D, Ihara G et al (2011) Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats. J Hypertens 29:290–298
    • (2011) J Hypertens , vol.29 , pp. 290-298
    • Rafiq, K.1    Nakano, D.2    Ihara, G.3
  • 36
    • 84856226885 scopus 로고    scopus 로고
    • Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor
    • COI: 1:CAS:528:DC%2BC38XovFOitg%3D%3D
    • Sherajee SJ, Fujita Y, Rafiq K et al (2012) Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor. Arterioscler Thromb Vasc Biol 32:257–263
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 257-263
    • Sherajee, S.J.1    Fujita, Y.2    Rafiq, K.3
  • 37
    • 84859739099 scopus 로고    scopus 로고
    • Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences
    • COI: 1:CAS:528:DC%2BC38Xmsl2gsbk%3D
    • Sabolic I, Vrhovac I, Eror DB et al (2012) Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol 302:C1174–C1188
    • (2012) Am J Physiol Cell Physiol , vol.302 , pp. 1174-1188
    • Sabolic, I.1    Vrhovac, I.2    Eror, D.B.3
  • 38
    • 0031036701 scopus 로고    scopus 로고
    • Sympathetic nerve hyperactivity precedes hyperinsulinemia and blood pressure elevation in a young, nonobese Japanese population
    • COI: 1:STN:280:DyaK2s7mtV2mtw%3D%3D
    • Masuo K, Mikami H, Ogihara T, Tuck ML (1997) Sympathetic nerve hyperactivity precedes hyperinsulinemia and blood pressure elevation in a young, nonobese Japanese population. Am J Hypertens 10:77–83
    • (1997) Am J Hypertens , vol.10 , pp. 77-83
    • Masuo, K.1    Mikami, H.2    Ogihara, T.3    Tuck, M.L.4
  • 39
    • 23944516469 scopus 로고    scopus 로고
    • Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome
    • COI: 1:STN:280:DC%2BD2Mznt1Wjug%3D%3D
    • Grassi G, Dell'Oro R, Quarti-Trevano F et al (2005) Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 48:1359–1365
    • (2005) Diabetologia , vol.48 , pp. 1359-1365
    • Grassi, G.1    Dell'Oro, R.2    Quarti-Trevano, F.3
  • 40
    • 0027514229 scopus 로고
    • Reflex sympathetic activation induces acute insulin resistance in the human forearm
    • COI: 1:CAS:528:DyaK3sXksVWgu7Y%3D
    • Jamerson KA, Julius S, Gudbrandsson T, Andersson O, Brant DO (1993) Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension 21:618–623
    • (1993) Hypertension , vol.21 , pp. 618-623
    • Jamerson, K.A.1    Julius, S.2    Gudbrandsson, T.3    Andersson, O.4    Brant, D.O.5
  • 41
    • 10244267463 scopus 로고    scopus 로고
    • Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives
    • COI: 1:CAS:528:DC%2BD2cXhtFaitbbF
    • Grassi G, Dell'Oro R, Facchini A, Quarti Trevano F, Bolla GB, Mancia G (2004) Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives. J Hypertens 22:2363–2369
    • (2004) J Hypertens , vol.22 , pp. 2363-2369
    • Grassi, G.1    Dell'Oro, R.2    Facchini, A.3    Quarti Trevano, F.4    Bolla, G.B.5    Mancia, G.6
  • 42
    • 0032217173 scopus 로고    scopus 로고
    • I1-imidazoline agonist moxonidine decreases sympathetic nerve activity and blood pressure in hypertensives
    • COI: 1:CAS:528:DyaK1MXitVWjuw%3D%3D
    • Wenzel RR, Spieker L, Qui S, Shaw S, Luscher TF, Noll G (1998) I1-imidazoline agonist moxonidine decreases sympathetic nerve activity and blood pressure in hypertensives. Hypertension 32:1022–1027
    • (1998) Hypertension , vol.32 , pp. 1022-1027
    • Wenzel, R.R.1    Spieker, L.2    Qui, S.3    Shaw, S.4    Luscher, T.F.5    Noll, G.6
  • 43
    • 0032954960 scopus 로고    scopus 로고
    • Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic fatty rat model of type 2 diabetes
    • COI: 1:CAS:528:DyaK1MXjtFSgtrY%3D
    • Yakubu-Madus FE, Johnson WT, Zimmerman KM, Dananberg J, Steinberg MI (1999) Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic fatty rat model of type 2 diabetes. Diabetes 48:1093–1100
    • (1999) Diabetes , vol.48 , pp. 1093-1100
    • Yakubu-Madus, F.E.1    Johnson, W.T.2    Zimmerman, K.M.3    Dananberg, J.4    Steinberg, M.I.5
  • 44
    • 79960095410 scopus 로고    scopus 로고
    • The efficacy and safety of moxonidine in patients with metabolic syndrome (the O.B.E.Z.I.T.A. trial)
    • COI: 1:STN:280:DC%2BC3MnnvVKisg%3D%3D
    • Krupicka J, Soucek M, Chroust K (2011) The efficacy and safety of moxonidine in patients with metabolic syndrome (the O.B.E.Z.I.T.A. trial). Vnitr Lek 57:541–545
    • (2011) Vnitr Lek , vol.57 , pp. 541-545
    • Krupicka, J.1    Soucek, M.2    Chroust, K.3
  • 45
    • 0036305976 scopus 로고    scopus 로고
    • Placebo-controlled comparison of the efficacy and tolerability of once-daily moxonidine and enalapril in mild to moderate essential hypertension
    • COI: 1:CAS:528:DC%2BD38XlvFyrtrc%3D
    • Prichard BN, Jager BA, Luszick JH et al (2002) Placebo-controlled comparison of the efficacy and tolerability of once-daily moxonidine and enalapril in mild to moderate essential hypertension. Blood Press 11:166–172
    • (2002) Blood Press , vol.11 , pp. 166-172
    • Prichard, B.N.1    Jager, B.A.2    Luszick, J.H.3
  • 46
    • 0021342251 scopus 로고
    • Serum glucose levels during long-term observation of treated and untreated men with mild hypertension. The Oslo study
    • COI: 1:CAS:528:DyaL2cXks1Gks7g%3D
    • Helgeland A, Leren P, Foss OP, Hjermann I, Holme I, Lund-Larsen PG (1984) Serum glucose levels during long-term observation of treated and untreated men with mild hypertension. The Oslo study. Am J Med 76:802–805
    • (1984) Am J Med , vol.76 , pp. 802-805
    • Helgeland, A.1    Leren, P.2    Foss, O.P.3    Hjermann, I.4    Holme, I.5    Lund-Larsen, P.G.6
  • 47
    • 0018755838 scopus 로고
    • Differences in metabolic responses to beta-adrenergic stimulation after propranolol or metoprolol administration
    • COI: 1:CAS:528:DyaE1MXhtFGnsbo%3D
    • William-Olsson T, Fellenius E, Bjorntorp P, Smith U (1979) Differences in metabolic responses to beta-adrenergic stimulation after propranolol or metoprolol administration. Acta Med Scand 205:201–206
    • (1979) Acta Med Scand , vol.205 , pp. 201-206
    • William-Olsson, T.1    Fellenius, E.2    Bjorntorp, P.3    Smith, U.4
  • 48
    • 0031056252 scopus 로고    scopus 로고
    • The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects
    • COI: 1:STN:280:DyaK2s7ptlOruw%3D%3D
    • Gudbjornsdottir S, Fowelin J, Elam M et al (1997) The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects. Euro J Clin Investig 27:29–35
    • (1997) Euro J Clin Investig , vol.27 , pp. 29-35
    • Gudbjornsdottir, S.1    Fowelin, J.2    Elam, M.3
  • 49
    • 0024598064 scopus 로고
    • Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients
    • COI: 1:STN:280:DyaL1M3oslGmug%3D%3D
    • Pollare T, Lithell H, Selinus I, Berne C (1989) Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. Br Med J 298:1152–1157
    • (1989) Br Med J , vol.298 , pp. 1152-1157
    • Pollare, T.1    Lithell, H.2    Selinus, I.3    Berne, C.4
  • 50
    • 0016719602 scopus 로고
    • The metabolic consequences of adrenergic blockade: a review
    • COI: 1:STN:280:DyaE2M7ptl2rsg%3D%3D
    • Day JL (1975) The metabolic consequences of adrenergic blockade: a review. Metab Clin Exp 24:987–996
    • (1975) Metab Clin Exp , vol.24 , pp. 987-996
    • Day, J.L.1
  • 51
    • 0018755660 scopus 로고
    • Effect of cardioselective and non-selective beta-blockade on the hypoglycaemic response in insulin-dependent diabetics
    • COI: 1:STN:280:DyaE1M7jtlOqsg%3D%3D
    • Lager I, Blohme G, Smith U (1979) Effect of cardioselective and non-selective beta-blockade on the hypoglycaemic response in insulin-dependent diabetics. Lancet 1:458–462
    • (1979) Lancet , vol.1 , pp. 458-462
    • Lager, I.1    Blohme, G.2    Smith, U.3
  • 52
    • 0030978999 scopus 로고    scopus 로고
    • Role of the kidney in plasma glucose regulation during hyperglycemia
    • COI: 1:CAS:528:DyaK2sXjsFCisb4%3D
    • Cersosimo E, Ajmal M, Naukam RJ, Molina PE, Abumrad NN (1997) Role of the kidney in plasma glucose regulation during hyperglycemia. Am J Physiol 272:E756–E761
    • (1997) Am J Physiol , vol.272 , pp. 756-761
    • Cersosimo, E.1    Ajmal, M.2    Naukam, R.J.3    Molina, P.E.4    Abumrad, N.N.5
  • 53
    • 0002874570 scopus 로고
    • Gene expression of epithelial glucose transporters: the role of diabetes mellitus
    • COI: 1:CAS:528:DyaK2MXivFSktLg%3D
    • Dominguez JH, Song B, Maianu L, Garvey WT, Qulali M (1994) Gene expression of epithelial glucose transporters: the role of diabetes mellitus. J Am Soc Nephrol 5:S29–S36
    • (1994) J Am Soc Nephrol , vol.5 , pp. 29-36
    • Dominguez, J.H.1    Song, B.2    Maianu, L.3    Garvey, W.T.4    Qulali, M.5
  • 54
    • 78651406659 scopus 로고    scopus 로고
    • SGLT2 mediates glucose reabsorption in the early proximal tubule
    • COI: 1:CAS:528:DC%2BC3MXhsVChsrY%3D
    • Vallon V, Platt KA, Cunard R et al (2011) SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol 22:104–112
    • (2011) J Am Soc Nephrol , vol.22 , pp. 104-112
    • Vallon, V.1    Platt, K.A.2    Cunard, R.3
  • 55
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • COI: 1:CAS:528:DC%2BC3MXns1Cms7g%3D
    • Wright EM, Loo DD, Hirayama BA (2011) Biology of human sodium glucose transporters. Physiol Rev 91:733–794
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 56
    • 0028044629 scopus 로고
    • The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose
    • COI: 1:CAS:528:DyaK2cXitFensbs%3D
    • Kanai Y, Lee WS, You G, Brown D, Hediger MA (1994) The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Investig 93:397–404
    • (1994) J Clin Investig , vol.93 , pp. 397-404
    • Kanai, Y.1    Lee, W.S.2    You, G.3    Brown, D.4    Hediger, M.A.5
  • 57
    • 0026506131 scopus 로고
    • Molecular evidence for two renal Na+/glucose cotransporters
    • COI: 1:CAS:528:DyaK38XisFakt70%3D
    • Pajor AM, Hirayama BA, Wright EM (1992) Molecular evidence for two renal Na+/glucose cotransporters. Biochim Biophys Acta 1106:216–220
    • (1992) Biochim Biophys Acta , vol.1106 , pp. 216-220
    • Pajor, A.M.1    Hirayama, B.A.2    Wright, E.M.3
  • 58
    • 84891699355 scopus 로고    scopus 로고
    • Renal denervation prevents stroke and brain injury via attenuation of oxidative stress in hypertensive rats
    • Nakagawa T, Hasegawa Y, Uekawa K et al (2013) Renal denervation prevents stroke and brain injury via attenuation of oxidative stress in hypertensive rats. J Am Heart Assoc 2:e000375
    • (2013) J Am Heart Assoc , vol.2
    • Nakagawa, T.1    Hasegawa, Y.2    Uekawa, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.