Thymoquinone Inhibits IL-1β-Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF-κB and MAPKs Signaling Pathway

Inflammation

Volumn 38, Issue 6, 2015, Pages 2235-2241

  Wang, Dongyan ^a   Qiao, Jiutao ^a   Zhao, Xin ^a   Chen, Tianxin ^a   Guan, Dehong ^a  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

IL 1 ; NF B; osteoarthritis chondrocyte; thymoquinone

Indexed keywords

COLLAGENASE 3; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; STROMELYSIN; THYMOQUINONE; ANTIINFLAMMATORY AGENT; AUTACOID; BENZOQUINONE DERIVATIVE; I KAPPA B; IL1B PROTEIN, HUMAN; NF-KAPPAB INHIBITOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL CULTURE; CELL VIABILITY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; JAPAN; MALE; MIDDLE AGED; OSTEOARTHRITIS; SIGNAL TRANSDUCTION; TOTAL KNEE REPLACEMENT; WESTERN BLOTTING; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; OSTEOARTHRITIS, KNEE;

ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OSTEOARTHRITIS, KNEE; SIGNAL TRANSDUCTION;

EID: 84946490329     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-015-0206-1     Document Type: Article

References (26)

1. Moe, R.H., T. Uhlig, I. Kjeken, K.B. Hagen, T.K. Kvien, and M. Grotle. 2010. Multidisciplinary and multifaceted outpatient management of patients with osteoarthritis: protocol for a randomised, controlled trial. BMC Musculoskeletal Disorders 11: 253.
2. Helmick, C.G., D.T. Felson, R.C. Lawrence, S. Gabriel, R. Hirsch, C.K. Kwoh, M.H. Liang, H.M. Kremers, M.D. Mayes, P.A. Merkel, et al. 2008. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis and Rheumatism 58: 15–25.
3. Melchiorri, C., R. Meliconi, L. Frizziero, T. Silvestri, L. Pulsatelli, I. Mazzetti, R.M. Borzi, M. Uguccioni, and A. Facchini. 1998. Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis and Rheumatism 41: 2165–2174.
4. Fernandes, J.C., J. Martel-Pelletier, and J.P. Pelletier. 2002. The role of cytokines in osteoarthritis pathophysiology. Biorheology 39: 237–246.
5. Honorati, M.C., L. Cattini, and A. Facchini. 2004. IL-17, IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes. Osteoarthritis and Cartilage 12: 683–691.
6. Lianxu, C., J. Hongti, and Y. Changlong. 2006. NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. Osteoarthritis and Cartilage 14: 367–376.
7. Tetlow, L.C., D.J. Adlam, and D.E. Woolley. 2001. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis and Rheumatism 44: 585–594.
8. Chowdhury, T.T., D.L. Bader, and D.A. Lee. 2001. Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochemical and Biophysical Research Communications 285: 1168–1174.
9. Vergnolle, N., J.L. Wallace, N.W. Bunnett, and M.D. Hollenberg. 2001. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends in Pharmacological Sciences 22: 146–152.
10. Moon, D.O., M.O. Kim, Y.H. Choi, Y.M. Park, and G.Y. Kim. 2010. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. International Immunopharmacology 10: 605–610.
11. Abu-Dahab, R., F. Odeh, S.I. Ismail, H. Azzam, and A. Al Bawab. 2013. Preparation, characterization and antiproliferative activity of thymoquinone-beta-cyclodextrin self assembling nanoparticles. Pharmazie 68: 939–944.
12. Galaly, S.R., O.M. Ahmed, and A.M. Mahmoud. 2014. Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. Journal of Physiology and Pharmacology 65: 823–832.
13. Khalife, R., H. el Stephany, O. Tarras, M.H. Hodroj, and S. Rizk. 2014. Antiproliferative and proapoptotic effects of topotecan in combination with thymoquinone on acute myelogenous leukemia. Clinical Lymphoma, Myeloma & Leukemia 14(Suppl): S46–S55.
14. Hosseini, M., S. Zakeri, S. Khoshdast, F.T. Yousefian, M. Rastegar, F. Vafaee, S. Kahdouee, F. Ghorbani, H. Rakhshandeh, and S.A. Kazemi. 2012. The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats. Journal of Pharmacology Bioallied Science 4: 219–225.
15. Alkharfy, K.M., N.M. Al-Daghri, O.S. Al-Attas, and M.S. Alokail. 2011. The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice. International Immunopharmacology 11: 250–254.
16. Cheng, A.W., T.V. Stabler, M. Bolognesi, and V.B. Kraus. 2011. Selenomethionine inhibits IL-1beta inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes. Osteoarthritis and Cartilage 19: 118–125.
17. Sandell, L.J., X. Xing, C. Franz, S. Davies, L.W. Chang, and D. Patra. 2008. Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. Osteoarthritis and Cartilage 16: 1560–1571.
18. Towle, C.A., H.H. Hung, L.J. Bonassar, B.V. Treadwell, and D.C. Mangham. 1997. Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis. Osteoarthritis and Cartilage 5: 293–300.
19. Chowdhury, T.T., D.L. Bader, and D.A. Lee. 2006. Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology 43: 413–429.
20. Woodell-May, J., A. Matuska, M. Oyster, Z. Welch, K. O'Shaughnessey, and J. Hoeppner. 2011. Autologous protein solution inhibits MMP-13 production by IL-1beta and TNFalpha-stimulated human articular chondrocytes. Journal of Orthopaedic Research 29: 1320–1326.
21. Aida, Y., M. Maeno, N. Suzuki, H. Shiratsuchi, M. Motohashi, and H. Matsumura. 2005. The effect of IL-1beta on the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human chondrocytes. Life Sciences 77: 3210–3221.
22. Ghosh, S., M.J. May, and E.B. Kopp. 1998. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annual Review of Immunology 16: 225–260.
23. Lawrence, T., M. Bebien, G.Y. Liu, V. Nizet, and M. Karin. 2005. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434: 1138–1143.
24. Tak, P.P., and G.S. Firestein. 2001. NF-kappaB: a key role in inflammatory diseases. Journal of Clinical Investigation 107: 7–11.
25. De Martin, R., M. Hoeth, R. Hofer-Warbinek, and J.A. Schmid. 2000. The transcription factor NF-kappa B and the regulation of vascular cell function. Arteriosclerosis, Thrombosis, and Vascular Biology 20: E83–E88.
26. Ghosh, M., V. Aguirre, K. Wai, H. Felfly, W.D. Dietrich, and D.D. Pearse. 2015. The Interplay between Cyclic AMP, MAPK, and NF-kappa B pathways in response to proinflammatory signals in microglia. Biomedical Research International 2015: 308461.