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Volumn 29, Issue 11, 2015, Pages 2134-2142

Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms

Author keywords

[No Author keywords available]

Indexed keywords

ASXL1 PROTEIN; DNA METHYLTRANSFERASE 3A; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; NUCLEOPHOSMIN; PROTEIN; SRSF2 PROTEIN; STAG2 PROTEIN; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

EID: 84946489761     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2015.91     Document Type: Article
Times cited : (81)

References (34)
  • 3
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010; 18: 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 6
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010; 468: 839-843.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3    Pape, U.J.4    Tahiliani, M.5    Bandukwala, H.S.6
  • 7
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012; 483: 474-478.
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3    Rohle, D.4    Turcan, S.5    Abdel-Wahab, O.6
  • 8
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 2012; 483: 479-483.
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3    Walsh, L.A.4    Fang, F.5    Yilmaz, E.6
  • 9
    • 84862776918 scopus 로고    scopus 로고
    • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
    • Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 2012; 483: 484-488.
    • (2012) Nature , vol.483 , pp. 484-488
    • Koivunen, P.1    Lee, S.2    Duncan, C.G.3    Lopez, G.4    Lu, G.5    Ramkissoon, S.6
  • 10
    • 84875496294 scopus 로고    scopus 로고
    • (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
    • Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 2013; 339: 1621-1625.
    • (2013) Science , vol.339 , pp. 1621-1625
    • Losman, J.A.1    Looper, R.E.2    Koivunen, P.3    Lee, S.4    Schneider, R.K.5    McMahon, C.6
  • 11
    • 84884575080 scopus 로고    scopus 로고
    • Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
    • Chen C, Liu Y, Lu C, Cross JR, Morris JPt, Shroff AS et al. Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev 2013; 27: 1974-1985.
    • (2013) Genes Dev , vol.27 , pp. 1974-1985
    • Chen, C.1    Liu, Y.2    Lu, C.3    Cross, J.R.4    Morris, J.Pt.5    Shroff, A.S.6
  • 13
    • 84902081078 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice
    • Mylonas E, Janin M, Bawa O, Opolon P, David M, Quivoron C et al. Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice. Leukemia 2014; 28: 1343-1346.
    • (2014) Leukemia , vol.28 , pp. 1343-1346
    • Mylonas, E.1    Janin, M.2    Bawa, O.3    Opolon, P.4    David, M.5    Quivoron, C.6
  • 14
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013; 340: 626-630.
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3    Turcan, S.4    Grommes, C.5    Campos, C.6
  • 15
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 2013; 340: 622-626.
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3    Penard-Lacronique, V.4    Schalm, S.5    Hansen, E.6
  • 16
    • 84901020086 scopus 로고    scopus 로고
    • Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1
    • Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA et al. Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. J Biol Chem 2014; 289: 13717-13725.
    • (2014) J Biol Chem , vol.289 , pp. 13717-13725
    • Davis, M.I.1    Gross, S.2    Shen, M.3    Straley, K.S.4    Pragani, R.5    Lea, W.A.6
  • 17
    • 84888265282 scopus 로고    scopus 로고
    • Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
    • Chaturvedi A, Araujo Cruz MM, Jyotsana N, Sharma A, Yun H, Gorlich K et al. Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML. Blood 2013; 122: 2877-2887.
    • (2013) Blood , vol.122 , pp. 2877-2887
    • Chaturvedi, A.1    Araujo Cruz, M.M.2    Jyotsana, N.3    Sharma, A.4    Yun, H.5    Gorlich, K.6
  • 18
    • 84920973012 scopus 로고    scopus 로고
    • Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule
    • Deng G, Shen J, Yin M, McManus J, Mathieu M, Gee P et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. J Biol Chem 2014; 290: 762-774.
    • (2014) J Biol Chem , vol.290 , pp. 762-774
    • Deng, G.1    Shen, J.2    Yin, M.3    McManus, J.4    Mathieu, M.5    Gee, P.6
  • 19
    • 84900345062 scopus 로고    scopus 로고
    • Metabolic quirks yield tumour hope
    • Ledford H. Metabolic quirks yield tumour hope. Nature 2014; 508: 158-159.
    • (2014) Nature , vol.508 , pp. 158-159
    • Ledford, H.1
  • 22
    • 74949108515 scopus 로고    scopus 로고
    • Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies
    • Makishima H, Cazzolli H, Szpurka H, Dunbar A, Tiu R, Huh J et al. Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. J Clin Oncol 2009; 27: 6109-6116.
    • (2009) J Clin Oncol , vol.27 , pp. 6109-6116
    • Makishima, H.1    Cazzolli, H.2    Szpurka, H.3    Dunbar, A.4    Tiu, R.5    Huh, J.6
  • 23
    • 84893772765 scopus 로고    scopus 로고
    • Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
    • Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia 2014; 28: 241-247.
    • (2014) Leukemia , vol.28 , pp. 241-247
    • Haferlach, T.1    Nagata, Y.2    Grossmann, V.3    Okuno, Y.4    Bacher, U.5    Nagae, G.6
  • 24
    • 84884521244 scopus 로고    scopus 로고
    • Accurately identifying lowallelic fraction variants in single samples with next-generation sequencing: Applications in tumor subclone resolution
    • Stead LF, Sutton KM, Taylor GR, Quirke P, Rabbitts P. Accurately identifying lowallelic fraction variants in single samples with next-generation sequencing: applications in tumor subclone resolution. Hum Mutat 2013; 34: 1432-1438.
    • (2013) Hum Mutat , vol.34 , pp. 1432-1438
    • Stead, L.F.1    Sutton, K.M.2    Taylor, G.R.3    Quirke, P.4    Rabbitts, P.5
  • 25
    • 84906505215 scopus 로고    scopus 로고
    • The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone
    • Molenaar RJ, Verbaan D, Lamba S, Zanon C, Jeuken JW, Boots-Sprenger SH et al. The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone. Neuro Oncol 2014; 16: 1263-1273.
    • (2014) Neuro Oncol , vol.16 , pp. 1263-1273
    • Molenaar, R.J.1    Verbaan, D.2    Lamba, S.3    Zanon, C.4    Jeuken, J.W.5    Boots-Sprenger, S.H.6
  • 26
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011; 19: 17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6
  • 28
    • 84876889621 scopus 로고    scopus 로고
    • What a difference a hydroxyl makes: Mutant IDH, (R)-2-hydroxyglutarate, and cancer
    • Losman JA, Kaelin WG Jr. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev 2013; 27: 836-852.
    • (2013) Genes Dev , vol.27 , pp. 836-852
    • Losman, J.A.1    Kaelin, W.G.2
  • 29
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
    • Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 2011; 118: 3932-3941.
    • (2011) Blood , vol.118 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3    Szpurka, H.4    Huang, Y.5    Traina, F.6
  • 30
    • 84915789576 scopus 로고    scopus 로고
    • DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
    • Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep 2014; 9: 1841-1855.
    • (2014) Cell Rep , vol.9 , pp. 1841-1855
    • Rampal, R.1    Alkalin, A.2    Madzo, J.3    Vasanthakumar, A.4    Pronier, E.5    Patel, J.6
  • 31
    • 65349150503 scopus 로고    scopus 로고
    • IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
    • Watanabe T, Nobusawa S, Kleihues P, Ohgaki HC. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol 2009; 174: 1149-1153.
    • (2009) Am J Pathol , vol.174 , pp. 1149-1153
    • Watanabe, T.1    Nobusawa, S.2    Kleihues, P.3    Ohgaki, H.C.4
  • 32
    • 84892373020 scopus 로고    scopus 로고
    • Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
    • Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 2013; 343: 189-193.
    • (2013) Science , vol.343 , pp. 189-193
    • Johnson, B.E.1    Mazor, T.2    Hong, C.3    Barnes, M.4    Aihara, K.5    McLean, C.Y.6
  • 34
    • 84868342138 scopus 로고    scopus 로고
    • Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: A meta-analysis
    • Zhou KG, Jiang LJ, Shang Z, Wang J, Huang L, Zhou JF. Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: A meta-analysis. Leuk Lymph 2012; 53: 2423-2429.
    • (2012) Leuk Lymph , vol.53 , pp. 2423-2429
    • Zhou, K.G.1    Jiang, L.J.2    Shang, Z.3    Wang, J.4    Huang, L.5    Zhou, J.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.