Insulin-secreting adipose-derived mesenchymal stromal cells with bone marrow-derived hematopoietic stem cells from autologous and allogenic sources for type 1 diabetes mellitus

Cytotherapy

Volumn 17, Issue 7, 2015, Pages 940-947

  Thakkar, Umang G ^a   Trivedi, Hargovind L ^a   Vanikar, Aruna V ^a,b   Dave, Shruti D ^b  

^a Dr HL Trivedi Institute of Transplantation Sciences   (India)

^b Department of Pathology Laboratory Medicine and Transfusion Services Department of Immunohematology GR Doshi and KM Mehta Institute of Kidney Diseases and Research Centre   (India)

Author keywords

C peptide; Glycosylated hemoglobin; Insulin requirement; Insulin secreting cells; Mesenchymal stromal cells; Stem cell therapy; Type 1 diabetes mellitus

Indexed keywords

C PEPTIDE; CD34 ANTIGEN; CD45 ANTIGEN; GLUCOSE; GLUTAMATE DECARBOXYLASE ANTIBODY; GLYCOSYLATED HEMOGLOBIN; GLUCOSE BLOOD LEVEL; INSULIN; PTPRC PROTEIN, HUMAN;

ADIPOSE DERIVED STEM CELL; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CELL DIFFERENTIATION; CHILD; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INTERMETHOD COMPARISON; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONMYELOABLATIVE CONDITIONING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; ADIPOSE TISSUE; BIOLOGICAL THERAPY; BLOOD; BONE MARROW CELL; CLINICAL TRIAL; CYTOLOGY; DIABETES MELLITUS, TYPE 1; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; OBESITY; PROCEDURES; SECRETION (PROCESS); SUBCUTANEOUS FAT; YOUNG ADULT;

ADIPOSE TISSUE; ADULT; ANTIGENS, CD45; BLOOD GLUCOSE; BONE MARROW CELLS; C-PEPTIDE; CELL- AND TISSUE-BASED THERAPY; DIABETES MELLITUS, TYPE 1; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; OBESITY; PROSPECTIVE STUDIES; SUBCUTANEOUS FAT; YOUNG ADULT;

EID: 84946485646     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2015.03.608     Document Type: Article

References (22)

1. Vanikar A.V., Dave S.D., Thakkar U.G., Trivedi H.L. Co-transplantation of adipose tissue derived insulin-secreting mesenchymal stem cells and hematopoietic stem cells: a novel therapy for insulin-dependent diabetes mellitus. Stem Cells Int 2010, 2010:582382.
2. Mehra N.K., Kumar N., Kaur G., Kanga U., Tandon N. "Biomarkers of susceptibility to type 1 diabetes with special reference to the Indian population". Indian J Med Res 2007, 125:321-344.
3. Nathan D.M. "Long-term complications of diabetes mellitus". N Engl J Med 1993, 328:1676-1685.
4. Rubin R.R., Peyrot M. "Quality of life and diabetes". Diabetes Metab Res Rev 1999, 15:205-218.
5. Voltarelli J.C., Couri C.E., Stracieri A.B., Oliveira M.C., Moraes D.A., Pieroni F., et al. "Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus". JAMA 2007, 297:1568-1576.
6. Scharfmann R. Alternative sources of beta cells for cell therapy of diabetes. Eur J Clin Invest 2003, 33:595-600.
7. Lindolfo da Silva M., Aparecida M.F., Dimas T.C., Arnold I.C. Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 2009, 20:419-427.
8. Dave S.D., Vanikar A.V., Trivedi H.L. In-vitro generation of human adipose tissue derived insulin secreting cells: up-regulation of Pax-6, Ipf-1 and Isl-1. Cytotechnology 2014, 66:299-307.
9. Dave S.D., Vanikar A.V., Trivedi H.L. Ex vivo generation of glucose sensitive insulin secreting mesenchymal stem cells derived from human adipose tissue. Indian J Endocr Metab 2012, 16:S65-S69.
10. Shapiro A.M.J., Lakey J.R.T., Ryan E.A., Korbutt G.S., Toth E., Warnock G.L., et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid- free immunosuppressive regimen. N Engl J Med 2000, 343:230-238.
11. Shapiro A.M., Ricordi C., Hering B. Edmonton's islet success has indeed been replicated elsewhere. Lancet 2003, 362:1242.
12. Henryk Z. Stem cells with potential to generate insulin-producing cells in man. Swiss Med Wkly 2006, 136:647-654.
13. Brusko T.M. Mesenchymal Stem Cells: A Potential Border Patrol for Transplanted Islets?. Diabetes 2009, 58:1728-1729.
14. Abdi R., Fiorina P., Adra C.N., Atkinson M., Sayegh M.H. Immunomodulation by mesenchymal stem cells: A potential therapeutic strategy for type 1 diabetes. Diabetes 2008, 57:1759-1767.
15. Nauta A.J., Fibbe W.E. Immunomodulatory properties of mesenchymal stromal cells. Blood 2007, 110:3499-3506.
16. Volarevic V., Al-Qahtani A., Arsenijevic N., Pajovic S., Lukic M.L. Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis. Autoimmunity 2010, 43:255-263.
17. Lee R.H., Seo M.J., Reger R.L., Spees J.L., Pulin A.A., Olson S.D., et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/SCID mice. Proc Natl Acad Sci U S A 2006, 103:17438-17443.
18. Urban V.S., Kiss J., Kovacs J., Gocza E., Vas V., Monostori E., et al. Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes. Stem Cells 2008, 26:244-253.
19. Sprent J., Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci 2001, 356:609-616.
20. Starzl T.E. The "Privileged" Liver and Hepatic Tolerogenicity. Liver Transpl 2001, 7:918-920.
21. Prokhorova T.A., Harkness L.M., Frandsen U., Ditzel N., Schroder H.D., Burns J.S., et al. Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of Matrigel. Stem Cells Dev 2009, 18:47-54.
22. Trivedi H.L., Vanikar A.V., Thakker U., Firoze A., Dave S.D., Patel C.N., et al. Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin. Transplant Proc 2008, 40:1135-1139.