Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

Biotechnology and Bioengineering

Volumn 112, Issue 12, 2015, Pages 2571-2582

  Kang, Young Bok Abraham ^a   Sodunke, Temitope R ^a   Lamontagne, Jason ^b   Cirillo, Joseph ^a   Rajiv, Caroline ^b   Bouchard, Michael J ^b   Noh, Moses ^a  

^a Drexel University   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Liver model; Liver on a chip; Liver sinusoid; Long term co culture; Microfluidic platform

Indexed keywords

CELL CULTURE; MICROCHANNELS; MICROFLUIDICS; RATS; UREA; VIRUSES;

BOVINE AORTIC ENDOTHELIAL CELLS; CO-CULTURES; CONTINUOUS PERFUSIONS; EXPERIMENTAL CONDITIONS; LIVER MODELING; MICROFLUIDIC PLATFORMS; PRIMARY RAT HEPATOCYTES; REPLICATION STRATEGIES;

ENDOTHELIAL CELLS;

UREA; VIRUS DNA;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL INTERACTION; CELL ISOLATION; CELL STRUCTURE; CELL VIABILITY; COCULTURE; ENDOTHELIUM CELL; EXPERIMENTAL CATTLE; HEPATITIS B VIRUS; IN VITRO STUDY; KUPFFER CELL; LAB ON A CHIP; LIVER CELL; LIVER CELL CULTURE; LIVER FUNCTION; LIVER SINUSOID; MICROFLUIDICS; NONHUMAN; PHASE CONTRAST MICROSCOPY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SHEAR STRESS; STEADY STATE; STELLATE CELL; UREA CYCLE; VIRUS REPLICATION; ANIMAL; ARTIFICIAL LIVER; BOVINE; CELL CULTURE; CELL SURVIVAL; METABOLISM; PHYSIOLOGY; PROCEDURES; TIME FACTOR;

ANIMALS; CATTLE; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; DNA, VIRAL; ENDOTHELIAL CELLS; HEPATITIS B VIRUS; HEPATOCYTES; LIVER, ARTIFICIAL; MICROFLUIDICS; RATS; TIME FACTORS; UREA; VIRUS REPLICATION;

EID: 84946476258     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25659     Document Type: Article

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