POLE mutations in families predisposed to cutaneous melanoma

Familial Cancer

Volumn 14, Issue 4, 2015, Pages 621-628

  Aoude, Lauren G ^a   Heitzer, Ellen ^b   Johansson, Peter ^a   Gartside, Michael ^a   Wadt, Karin ^d   Pritchard, Antonia L ^a   Palmer, Jane M ^a   Symmons, Judith ^a   Gerdes, Anne Marie ^d   Montgomery, Grant W ^a   Martin, Nicholas G ^a   Tomlinson, Ian ^e   Kearsey, Stephen ^c   Hayward, Nicholas K ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Rigshospitalet   (Denmark)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cutaneous melanoma; Germline mutation; POLE

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DEOXYRIBONUCLEOPROTEIN; EXONUCLEASE; POLE PROTEIN; UNCLASSIFIED DRUG; DNA DIRECTED DNA POLYMERASE ALPHA; POLE PROTEIN, HUMAN; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; ARTICLE; CAUCASIAN; CONTROLLED STUDY; CUTANEOUS MELANOMA; ENZYME ACTIVITY; EXOME; FEMALE; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENOME; GERMLINE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CANCER; MUTATION RATE; PENETRANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SCHIZOSACCHAROMYCES POMBE; SEQUENCE ANALYSIS; TUMOR GENE; CANCER STAGING; FOLLOW UP; GENETICS; HIGH THROUGHPUT SEQUENCING; MELANOMA; MIDDLE AGED; PATHOLOGY; PEDIGREE; PROGNOSIS; SKIN TUMOR; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; DNA POLYMERASE II; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MELANOMA; MIDDLE AGED; NEOPLASM STAGING; PEDIGREE; PROGNOSIS; SKIN NEOPLASMS; YOUNG ADULT;

EID: 84946475881     PISSN: 13899600     EISSN: 15737292     Source Type: Journal    
DOI: 10.1007/s10689-015-9826-8     Document Type: Article

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