Ameliorative effect of quercetin against arsenic-induced sperm DNA damage and daily sperm production in adult male rats

Drug and Chemical Toxicology

Volumn 39, Issue 3, 2016, Pages 290-296

  Jahan, Sarwat ^a   Rehman, Saima ^a   Ullah, Hizb ^a   Munawar, Asma ^a   Ain, Qurat Ul ^a   Iqbal, Tariq ^a  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

Author keywords

Arsenic; DNA damage; epididymis; quercetin; sperm production

Indexed keywords

ARSENITE SODIUM; DNA; QUERCETIN; ANTIOXIDANT; ARSENOUS ACID DERIVATIVE; POLLUTANT; SODIUM DERIVATIVE;

ADULT; ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COMET ASSAY; CONTROLLED STUDY; DAILY SPERM PRODUCTION; DECAPITATION; DNA DAMAGE; EPIDIDYMIS; HISTOLOGY; MALE; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SPERMATOGENESIS; SPERMATOZOON DENSITY; SPERMATOZOON TAIL; SPRAGUE DAWLEY RAT; ANIMAL; ATOMIC ABSORPTION SPECTROMETRY; DRUG EFFECTS; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHARMACOKINETICS; POLLUTANT; SPERMATOZOON; SPERMATOZOON COUNT; TESTIS; TOXICITY;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; ARSENITES; COMET ASSAY; DNA DAMAGE; ENVIRONMENTAL POLLUTANTS; EPIDIDYMIS; MALE; QUERCETIN; RATS, SPRAGUE-DAWLEY; SODIUM COMPOUNDS; SPECTROPHOTOMETRY, ATOMIC; SPERM COUNT; SPERMATOZOA; TESTIS;

EID: 84946422897     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2015.1101772     Document Type: Article

References (53)

1. Abernathy CO, Liu YP, Longfellow D, et al. (1999). Arsenic: health effects, mechanisms of actions, and research issues. Environ Health Perspect 107: 593-597
2. Agarwal A, Makker K, Sharma R. (2008). Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 59: 2-11
3. Akram Z, Jalali S, Shami S, et al. (2009). Genotoxicity of sodium arsenite and DNA fragmentation in ovarian cells of rats. Toxicol Lett 1: 81-85
4. Bakheet SA. (2011). Assessment of anti-cytogenotoxic effects of quercetin in animals treated with topotecan. Oxid Med Cell Longev 2011; 2011: 824597
5. Balakumar B, Ramanathan K, Kumaresan S, et al. (2010). DNA damage by sodium arsenite in experimental rats: ameliorative effects of antioxidant vitamins C and E. Ind J Sci Tech 3: 322-327
6. Barcelos GRM, Grotto G, Serpeloni JM, et al. (2011). Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Arch Toxicol 85: 1151-1157
7. Biswas NM, Roy CG, Sarkar M. (1994). Effect of sodium arsenite on adrenocortical activities in male rats: dose-duration dependent responses. Med Sci Res 23: 153-154
8. Boe-Hansen GB, Morris ID, Ersboll AK, et al. (2005). DNA integrity in sexed bull sperm assessed by neutral comet assay and sperm chromatin structure assay. Theriogenology 63: 1789-1802
9. Bu T, Mi Y, Zeng W, Zhang C. (2011). Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice. Anat Rec 294: 520-526
10. Caria H, Chaveca T, Laires A, et al. (1995). Genotoxicity of quercetin in the micronucleus assay in mouse bone marrow erythrocytes, human lymphocytes, V79 cell line and identification of kinetochore-containing (CREST staining) micronuclei in human lymphocytes. Mutat Res 343: 85-94
11. Chang SI, Jin B, Youn P, et al. (2007). Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis. Toxicol Appl Pharmacol 218: 196-203
12. Ciftci O, Aydin M, Ozdemir I, et al. (2012). Quercetin prevents 2,3,7,8-tetrachlorodibenzo- p -dioxininduced testicular damage in rats. Andrologia 44: 164-173
13. Ciftci O, Tanyildizi S, Godekmerdan A. (2010). Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD). Immunopharmacol Immunotoxicol 32: 99-104
14. Clegg KM, Morton AD. (1968). The phenolic compounds of blackcurrant juice and their protective effect on ascorbic acid. II. The stability of ascorbic acid in model systems containing some of the phenolic compounds associated with black currant juice. J Food Technol 3: 277-284
15. Collins A, Dusinska M, Franklin M, et al. (1997). Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ Mol Mutagen 30: 139-146
16. Cooke PS, Hess RA, Porcelli J, Meisami E. (1991). Increased sperm production in adult rats after transient neonatal hypothyroidism. Endocrinology 129: 244-248
17. Danielsson BRG, Dencker L, Lindgreen A, et al. (1984). Accumulation of toxic metals in male reproduction organs. Arch Toxicol Suppl 7: 177-180
18. Das J, Ghosh J, Manna P, et al. (2009). Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett 18: 201-210
19. Denis MC, Furtos F, Dudonné F, et al. (2013). Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation. PloS One 8: 53725
20. Farombi EO, Ekor M, Adedara IA, et al. (2012). Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of Quinine sulfate in rats. J Basic Clin Physiol Pharmacol 23: 39-134
21. Focazio MJ, Welch AH, Watkins SA, et al. (1999). A retrospective analysis on the occurrence of arsenic in ground-water resources of the United States and limitations in drinking water supply characterizations. USGS Water-Resourc Investig Rep 27: 4279
22. Ghosh S, Misro M, Das UB, et al. (2001). Effect of human chorionic gonadotrophin coadministration on ovarian steroidogenic and folliculogenic activities in cyclophosphamide treated albino rats. Reprod Toxicol 15: 221-225
23. Holstein AF, Schulze W, Davidoff M. (2003). Understanding spermatogenesis is a prerequisite for treatment. Reprod Biol Endocrinol 1: 107
24. Hughes MF, Kitchin KT. (2006). Arsenic, oxidative stress and carcinogenesis. In: Singh KK., ed. Oxidative stress, disease and cancer. London: Imperial College Press, 825-850
25. Islam MS, Awal MA, Mostofa M, et al. (2009). Effect of spinach against arsenic toxicity in rats. Bangl J Vet Med 7: 358-363
26. Jahan S, Iftikhar N, Ullah H, et al. (2015). Alleviative effect of quercetin on rat testis against arsenic: a histological and biochemical study. System Biol Reprod Medic 61:89-95
27. Jana K, Jana S, Samanta PK. (1999). Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of mechanisms of actions, and research issues. Environ Health Perspect 107: 593-597
28. Khan S, Telangb AG, Malika JK. (2013). Arsenic-induced oxidative stress, apoptosis and alterations in testicular steroidogenesis and spermatogenesis in wistar rats: ameliorative effect of curcumin. Wudpecker J Pharmacy Pharmocol 2: 033-048
29. Kitchin KT. (2001). Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol 172: 249-261
30. Leopoldini M, Russo N, Chiodo S, et al. (2006). Iron chelation by the powerful antioxidant flavonoid quercetin. J Agric Food Chem 54: 6341-6351
31. Lewis DR, Southwick JW, Ouellet-Hellstrom R, et al. (1999). Drinking water arsenic in Utah: a cohort mortality study. Environ Health Perspect 107: 359-365
32. Nava-Hernandez MP, Hauad-Marroquin LA, Bassol-Mayagoitia S, et al. (2009). Lead-, cadmium-, and arsenic-induced DNA damage in rat germinal cells. DNA Cell Biol 28: 241-248
33. Nesnow S, Roop BC, Lambert G, et al. (2002). DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem Res Toxicol 15: 1627-1634
34. Nordstrom DK. (2002). Public health. Worldwide occurrences of arsenic in ground water. Science 296: 2143-2145
35. Pant N, Kumar R, Murthy RC, et al. (2001). Male reproductive effect of arsenic in mice. Biometals 14: 113-117
36. Patlolla AK, Todorov TI, Tchounwou PB, et al. (2012). Arsenic-induced biochemical and genotoxic effects and distribution in tissues of Sprague-Dawley rats. Microchem J 105: 101-107
37. Philips DM, Lakshmi V, Monder C. (1989). Corticosteroid 11 beta-dehydrogenase in rat testis. Endocrinology 125: 209-216
38. Prabu SM, Muthumani M, Shagirtha K. (2013). Quercetin potentially attenuates cadmium induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats. Eur Rev Med Pharmacol Sci 17: 582-595
39. Pratt D, Watts B. (1964). The antioxidant activity of vegetable extracts I. Flavone agylcone. J Food Sci 29: 27-33
40. Recio R, Robbins WA, Borja-Aburto V, et al. (2001). Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy. Environ Health Perspect 109: 1237-1240
41. Robb G, Amann R, Killian G. (1978). Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil 54: 103-107
42. Rossman TG, Uddin AN, Burns FJ. (2004). Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198: 394-404
43. Rueff J, Laires A, Gaspar J, et al. (1992). Oxygen species and the genotoxicity of quercetin. Mutat Res 265: 75-81
44. Sakkas D, Urner F, Bizzaro D. (1998). Sperm nuclear DNA damage and altered chromatin structure: effect on fertilization and embryo development. Hum Reprod 4: 11-19
45. Salup RR, Sicker DC, Wolmark N. (1992). Chemoimmunotherapy of metastatic murine renal cell carcinoma using flavone acetic acid and interleukin 2. J Urol 147: 1120-1123
46. Sarkar M, Chaudhuri GR, Chattopadhyay A. (2003). Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J Androl 5: 27-31
47. Sharpe RM, Maddocks S, Millar M. (1992). Testosterone and spermatogenesis. Identification of stage-specific, androgen-regulated proteins secreted by adult rat seminiferous tubules. J Androl 13: 172-184
48. Shukla JP, Pandey K. (1984). Impaired spermatogenesis in arsenic treated freshwater fish, Colisa fasciatus (Bl. and Sch.). Toxicol Lett 21: 191-195
49. Steinmaus C, Yuan Y, Bates MN, et al. (2003). Case-control study of bladder cancer and drinking water arsenic in the western United States. Am J Epidemiol 158: 1193-1201
50. Tchounwou PB, Wilson B, Ishaque A. (1999). Important considerations in the development of public health advisories for arsenic and arsenic containing compounds in drinking water. Rev Environ Health 14: 211-229
51. Walker JRL, Reddish CES. (1964). Note on the use of cysteine to prevent browning in apple. J Sci Food Agric 15: 902-904
52. Working PK, Bus JS, Hamm TE. (1985). Reproductive effects of inhaled methyl chloride in the male Fischer 344 rat. II. Spermatogonial toxicity and sperm quality. Toxicol Appl Pharm 77: 144-157
53. Zhu P, Ma Y, Huang Y. (2004). Role of DNA integrity in male infertility. Zhonghua Nan Ke Xue 1010: 222-226