Protracted dormancy of pre-leukemic stem cells

Leukemia

Volumn 29, Issue 11, 2015, Pages 2202-2207

  Ford, A M ^a   Mansur, M B ^a,b   Furness, C L ^a   Van Delft, F W ^c   Okamura, J ^d   Suzuki, T ^e   Kobayashi, H ^e   Kaneko, Y ^e   Greaves, M ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^c Newcastle Cancer Centre   (United Kingdom)

^d Department of Breast Oncology   (Japan)

^e Saitama Cancer Centre Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; CD19 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; MICROSOMAL AMINOPEPTIDASE; MYELOPEROXIDASE; NOTCH2 RECEPTOR; STAT2 PROTEIN; TRANSCRIPTION FACTOR PAX5; BCR-ABL1 FUSION PROTEIN, HUMAN; IKAROS TRANSCRIPTION FACTOR; IKZF1 PROTEIN, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER STEM CELL; CASE REPORT; CHROMOSOME 20; CHROMOSOME 21Q; COPY NUMBER VARIATION; GENE DELETION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOPHENOTYPING; INDEL MUTATION; KARYOTYPE; LEUKEMIA CELL; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; LEUKEMOGENESIS; MALE; MULTIPLEX POLYMERASE CHAIN REACTION; POINT MUTATION; PRE B LYMPHOCYTE; PRE LEUKEMIC STEM CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; SKULL IRRADIATION; EXOME; GENE DOSAGE; GENETICS; PATHOLOGY; PRESCHOOL CHILD;

CHILD, PRESCHOOL; EXOME; FUSION PROTEINS, BCR-ABL; GENE DOSAGE; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; HUMANS; IKAROS TRANSCRIPTION FACTOR; MALE; NEOPLASTIC STEM CELLS; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84946222465     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2015.132     Document Type: Article

References (36)

1. Malogolowkin M, Spreafico F, Dome JS, van Tinteren H, Pritchard-Jones K, van den Heuvel-Eibrink MM et al. Incidence and outcomes of patients with late recurrence of Wilms' tumor. Pediatr Blood Cancer 2013; 60: 1612-1615.
2. Tsao H, Cosimi AB, Sober AJ. Ultra-late recurrence (15 years or longer) of cutaneous melanoma. Cancer 1997; 79: 2361-2370.
3. Faries MB, Steen S, Ye X, Sim M, Morton DL. Late recurrence in melanoma: clinical implications of lost dormancy. J Am Coll Surg 2013; 217: 27-34.
4. Mir R, Phillips SL, Schwartz G, Mathur R, Khan A, Kahn LB. Metastatic neuroblastoma after 52 years of dormancy. Cancer 1987; 60: 2510-2514.
5. Goss PE, Chambers AF. Does tumour dormancy offer a therapeutic target? Nat Rev Cancer 2010; 10: 871-877.
6. Giancotti FG. Mechanisms governing metastatic dormancy and reactivation. Cell 2013; 155: 750-764.
7. Sosa MS, Bragado P, Aguirre-Ghiso JA. Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer 2014; 14: 611-622.
8. Chen J, Li Y, Yu T-S, McKay RM, Burns DK, Kernie SG et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012; 488: 522-526.
9. Frost L, Goodeve A, Wilson G, Peake I, Barker H, Vora A. Clonal stability in late-relapsing childhood lymphoblastic leukaemia. Br J Haematol 1997; 98: 992-994.
10. Vora A, Frost L, Goodeve A, Wilson G, Ireland RM, Lilleyman J et al. Late relapsing childhood lymphoblastic leukemia. Blood 1998; 92: 2334-2337.
11. Levasseur M, Maung ZT, Jackson GH, Kernahan J, Proctor SJ, Middleton PG. Relapse of acute lymphoblastic leukaemia 14 years after presentation: use of molecular techniques to confirm true re-emergency. Br J Haematol 1994; 87: 437-438.
12. Okamura J, Yamada S, Ishii E, Hara T, Takahira H, Nishimura J et al. A novel leukemia cell line, MR-87, with positive Philadelphia chromosome and negative breakpoint cluster region rearrangement coexpressing myeloid and early B-cell markers. Blood 1988; 72: 1261-1268.
13. van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257-2317.
14. Langerak AW, Groenen PJ, Bruggemann M, Beldjord K, Bellan C, Bonello L et al. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia 2012; 26: 2159-2171.
15. Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 2009; 25: 1754-1760.
16. McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A et al. The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 2010; 20: 1297-1303.
17. Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L et al. VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res 2012; 22: 568-576.
18. McLaren W, Pritchard B, Rios D, Chen Y, Flicek P, Cunningham F. Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor. Bioinformatics 2010; 26: 2069-2070.
19. Kodama Y, Okamura J, Fukano R, Nakashima K, Ito N, Nishimura M et al. Reemerging Philadelphia chromosome-positive acute leukaemia more than 20 years after allogeneic haematopoietic stem cell transplantation. Br J Haematol 2013; 161: 286-289.
20. Chen SJ, Chen Z, Font MP, d'Auriol L, Larsen CJ, Berger R. Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation. Nucleic Acids Res 1989; 17: 7631-7642.
21. Bessho F, Takayama N, Fronkova E, Zuna J. Reappearance of acute lymphoblastic leukemia 34 years after initial diagnosis: A case report and study of the origin of the reappeared blasts. Int J Hematol 2013; 97: 525-528.
22. Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, Colman SM et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2011; 469: 356-361.
23. Waanders E, Scheijen B, van der Meer LT, van Reijmersdal SV, van Emst L, Kroeze Y et al. The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution. PLoS Genet 2012; 8: e1002533.
24. Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC, Tubio J et al. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet 2014; 46: 116-125.
25. Hong D, Gupta R, Ancliffe P, Atzberger A, Brown J, Soneji S et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008; 319: 336-339.
26. Bateman CM, Colman SM, Chaplin T, Young BD, Eden TO, Bhakta M et al. Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia. Blood 2010; 115: 3553-3558.
27. Cazzaniga G, van Delft FW, Lo Nigro L, Ford AM, Score J, Iacobucci I et al. Developmental origins and effect of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia. Blood 2011; 118: 5559-5564.
28. Ford AM, Fasching K, Panzer-Grümayer ER, Koenig M, Haas OA, Greaves MF. Origins of 'late' relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes. Blood 2001; 98: 558-564.
29. van Delft FW, Horsley S, Colman S, Anderson K, Bateman C, Kempski H et al. Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia. Blood 2011; 117: 6247-6254.
30. Lutz C, Woll PS, Hall G, Castor A, Dreau H, Cazzaniga G et al. Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia. Leukemia 2013; 27: 1204-1207.
31. Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 2014; 506: 328-333.
32. Zhang X, Zhang Q, Dahlstrom J, Tran AN, Yang B, Gu Z et al. Genomic analysis of the clonal origin and evolution of acute promyelocytic leukemia in a unique patient with a very late (17 years) relapse. Leukemia 2014; 28: 1751-1754.
33. Sneddon JB, Werb Z. Location, location, location: The cancer stem cell niche. Cell Stem Cell 2007; 1: 607-611.
34. Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008; 135: 1118-1129.
35. Lewis K. Persister cells, dormancy and infectious disease. Nat Rev Microbiol 2007; 5: 48-56.
36. Pui CH, Pei D, Campana D, Cheng C, Sandlund JT, Bowman WP et al. A revised definition for cure of childhood acute lymphoblastic leukemia. Leukemia 2014; 28: 2336-2343.