Motivation and value influences in the relative balance of goal-directed and habitual behaviours in obsessive-compulsive disorder

Translational Psychiatry

Volumn 5, Issue , 2015, Pages

  Voon, V ^a,b,c   Baek, K ^a   Enander, J ^d   Worbe, Y ^a   Morris, L S ^a,b   Harrison, N A ^e   Robbins, T W ^a,b   Ruck C ^d   Daw, N ^f  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CAMBRIDGESHIRE AND PETERBOROUGH NHS FOUNDATION TRUST   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF SUSSEX   (United Kingdom)

^f NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; COMPULSION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HABIT; HUMAN; LEARNING; MALE; MENTAL TASK; MOTIVATION; PERSEVERATION; PERSONAL VALUE; RANDOMIZED CONTROLLED TRIAL; REWARD; OBSESSIVE COMPULSIVE DISORDER; PSYCHOLOGY; PSYCHOMOTOR PERFORMANCE;

ADULT; FEMALE; GOALS; HABITS; HUMANS; MALE; MOTIVATION; OBSESSIVE-COMPULSIVE DISORDER; PSYCHOMOTOR PERFORMANCE; REWARD;

EID: 84946209017     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2015.165     Document Type: Article

References (42)

1. Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW. Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci 2008; 363: 3125-3135.
2. Dickinson A, Balleine B. The role of learning in motivation. In: Gallistel CR (ed). Learning, Motivation, and Emotion. Wiley: New York, 2002, pp 497-533.
3. Dolan RJ, Dayan P. Goals and habits in the brain. Neuron 2013; 80: 312-325.
4. Daw ND, Niv Y, Dayan P. Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control. Nat Neurosci 2005; 8: 1704-1711.
5. Daw ND, Gershman SJ, Seymour B, Dayan P, Dolan RJ. Model-based influences on humans' choices and striatal prediction errors. Neuron 2011; 69: 1204-1215.
6. Voon V, Derbyshire K, Ruck C, Irvine MA, Worbe Y, Enander J et al. Disorders of compulsivity: a common bias towards learning habits. Mol Psychiatry 2014; 20: 345-352.
7. Deckersbach T, Savage CR, Curran T, Bohne A, Wilhelm S, Baer L et al. A study of parallel implicit and explicit information processing in patients with obsessivecompulsive disorder. Am J Psychiatry 2002; 159: 1780-1782.
8. Joel D, Zohar O, Afek M, Hermesh H, Lerner L, Kuperman R et al. Impaired procedural learning in obsessive-compulsive disorder and Parkinson's disease, but not in major depressive disorder. Behav Brain Res 2005; 157: 253-263.
9. Rauch SL, Wedig MM, Wright CI, Martis B, McMullin KG, Shin LM et al. Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder. Biol Psychiatry 2007; 61: 330-336.
10. Rauch SL, Whalen PJ, Savage CR, Curran T, Kendrick A, Brown HD et al. Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging. Hum Brain Mapp 1997; 5: 124-132.
11. Gillan CM, Papmeyer M, Morein-Zamir S, Sahakian BJ, Fineberg NA, Robbins TW et al. Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder. Am J Psychiatry 2011; 168: 718-726.
12. Ecker W, Gonner S. Incompleteness and harm avoidance in OCD symptom dimensions. Behav Res Ther 2008; 46: 895-904.
13. Endrass T, Kloft L, Kaufmann C, Kathmann N. Approach and avoidance learning in obsessive-compulsive disorder. Depress Anxiety 2011; 28: 166-172.
14. Kaufmann C, Beucke JC, Preusse F, Endrass T, Schlagenhauf F, Heinz A et al. Medial prefrontal brain activation to anticipated reward and loss in obsessivecompulsive disorder. Neuroimage Clin 2013; 2: 212-220.
15. Figee M, Vink M, de Geus F, Vulink N, Veltman DJ, Westenberg H et al. Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol Psychiatry 2011; 69: 867-874.
16. Jung WH, Kang DH, Han JY, Jang JH, Gu BM, Choi JS et al. Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessivecompulsive disorder. Acta Psychiatr Scand 2011; 123: 376-386.
17. Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM et al. Enhanced avoidance habits in obsessive-compulsive disorder. Biol Psychiatry 2014; 75: 631-638.
18. Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N et al. Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 2008; 321: 421-422.
19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn, text revision). American Psychiatric Association: Washington, D. C., USA, 2000.
20. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR et al. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry 1989; 46: 1012-1016.
21. Nelson HE. National Adult Reading Test. NFER-Nelson: Windsor, UK, 1982.
22. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571.
23. American Psychiatric Association. Practice Guideline for the Treatment of Patients with Obsessive-Compulsive Disorder. American Psychiatric Association: Arlington, VA, 2007.
24. Excellence NIfHaC. Obsessive-Compulsive Disorder: Core Interventions in the Treatment of Obsessive-Compulsive Disorder and Body Dysmorphic Disorder. The British Psychological Society and The Royal College of Psychiatrists: Leicester, London, UK, 2006.
25. Gruner P, Anticevic A, Lee D, Pittenger C. Arbitration between Action Strategies in Obsessive-Compulsive Disorder. Neuroscientist 2015.
26. Friedel E, Koch SP, Wendt J, Heinz A, Deserno L, Schlagenhauf F. Devaluation and sequential decisions: linking goal-directed and model-based behavior. Front Hum Neurosci 2014; 8: 587.
27. Soomro GM, Altman D, Rajagopal S, Oakley-Browne M. Selective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD). Cochrane Database Syst Rev 2008: CD001765.
28. Reimold M, Smolka MN, Zimmer A, Batra A, Knobel A, Solbach C et al. Reduced availability of serotonin transporters in obsessive-compulsive disorder correlates with symptom severity-A [11C]DASB PET study. J Neural Transm 2007; 114: 1603-1609.
29. Matsumoto R, Ichise M, Ito H, Ando T, Takahashi H, Ikoma Y et al. Reduced serotonin transporter binding in the insular cortex in patients with obsessivecompulsive disorder: a [11C]DASB PET study. Neuroimage 2010; 49: 121-126.
30. Hesse S, Stengler K, Regenthal R, Patt M, Becker GA, Franke A et al. The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder. Int J Neuropsychopharmacol 2011; 14: 606-617.
31. Hasselbalch SG, Hansen ES, Jakobsen TB, Pinborg LH, Lonborg JH, Bolwig TG. Reduced midbrain-pons serotonin transporter binding in patients with obsessivecompulsive disorder. Acta Psychiatr Scand 2007; 115: 388-394.
32. Hesse S, Muller U, Lincke T, Barthel H, Villmann T, Angermeyer MC et al. Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder. Psychiatry Res 2005; 140: 63-72.
33. Stengler-Wenzke K, Muller U, Angermeyer MC, Sabri O, Hesse S. Reduced serotonin transporter-Availability in obsessive-compulsive disorder (OCD). Eur Arch Psychiatry Clin Neurosci 2004; 254: 252-255.
34. Zitterl W, Aigner M, Stompe T, Zitterl-Eglseer K, Gutierrez-Lobos K, Schmidl-Mohl B et al. [123I]-beta-CIT SPECT imaging shows reduced thalamus-hypothalamus serotonin transporter availability in 24 drug-free obsessive-compulsive checkers. Neuropsychopharmacology 2007; 32: 1661-1668.
35. Pogarell O, Hamann C, Popperl G, Juckel G, Chouker M, Zaudig M et al. Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder. Biol Psychiatry 2003; 54: 1406-1413.
36. Simpson HB, Lombardo I, Slifstein M, Huang HY, Hwang DR, Abi-Dargham A et al. Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652. Biol Psychiatry 2003; 54: 1414-1421.
37. Perani D, Garibotto V, Gorini A, Moresco RM, Henin M, Panzacchi A et al. In vivo PET study of 5HT(2A) serotonin and D(2) dopamine dysfunction in drug-naive obsessive-compulsive disorder. Neuroimage 2008; 42: 306-314.
38. Adams KH, Hansen ES, Pinborg LH, Hasselbalch SG, Svarer C, Holm S et al. Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei. Int J Neuropsychopharmacol 2005; 8: 391-401.
39. Worbe Y, Palminteri S, Savulich G, Daw ND, Fernandez-Egea E, Robbins TW et al. Valence-dependent influence of serotonin depletion on model-based choice strategy. Mol Psychiatry 2015.
40. Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW et al. Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. Am J Psychiatry 2007; 164: 335-338.
41. Kuelz AK, Hohagen F, Voderholzer U. Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol 2004; 65: 185-236.
42. Watkins LH, Sahakian BJ, Robertson MM, Veale DM, Rogers RD, Pickard KM et al. Executive function in Tourette's syndrome and obsessive-compulsive disorder. Psychol Med 2005; 35: 571-582.