Special section on drug metabolism and the microbiome intestinal absorption and metabolism of epimedium flavonoids in osteoporosis rats

Drug Metabolism and Disposition

Volumn 43, Issue 10, 2015, Pages 1590-1600

  Zhou, Jing ^a   Ma, Yi Hua ^a   Zhou, Zhong ^a   Chen, Yan ^a   Wang, Ying ^a   Gao, Xia ^a  

^a KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BAOHUOSIDE I; EPIMEDIN A; EPIMEDIN B; EPIMEDIN C; FLAVONOID; ICARIIN; INTESTINE ENZYME; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ELIMINATION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG PENETRATION; DUODENUM; ENZYME ACTIVITY; EPIMEDIUM; FEMALE; ILEUM; INTESTINE ABSORPTION; INTESTINE FLORA; INTESTINE PERFUSION; JEJUNUM; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; DRUGS, CHINESE HERBAL; EPIMEDIUM; FEMALE; FLAVONOIDS; INTESTINAL ABSORPTION; OSTEOPOROSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84946207393     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.064386     Document Type: Article

References (39)

1. Abrahamsen B, Brask-Lindemann D, Rubin KH, and Schwarz P (2014) A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures. Bonekey Rep 3:574.
2. Akao T, Che QM, Kobashi K, Hattori M, and Namba T (1996) A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone. Biol Pharm Bull 19:136-138.
3. Andlauer W, Kolb J, and Fürst P (2000a) Absorption and metabolism of genistin in the isolated rat small intestine. FEBS Lett 475:127-130.
4. Andlauer W, Kolb J, and Fürst P (2000b) Isoflavones from tofu are absorbed and metabolized in the isolated rat small intestine. J Nutr 130:3021-3027.
5. Andlauer W, Kolb J, Stehle P, and Fürst P (2000c) Absorption and metabolism of genistein in isolated rat small intestine. J Nutr 130:843-846.
6. Bacsi K, Kosa JP, and Balla B (2007) The decreased activity of lactase phlorizin hydrolase and bone mineral density in postmenopausal women. J Bone Miner Res 22:186-198.
7. Bandeira F, Costa AG, Soares Filho MA, Pimentel L, Lima L, and Bilezikian JP (2014) Bone markers and osteoporosis therapy. Arq Bras Endocrinol Metabol 58:504-513.
8. Chen H and Kubo KY (2014) Bone three-dimensional microstructural features of the common osteoporotic fracture sites. World J Orthop 5:486-495.
9. Chen J, Lin H, and Hu M (2003) Metabolism of flavonoids via enteric recycling: role of intestinal disposition. J Pharmacol Exp Ther 304:1228-1235.
10. Chen Y, Wang Y, Zhou J, Gao X, Qu D, and Liu C (2014) Study on the mechanism of intestinal absorption of epimedins a, B and C in the Caco-2 cell model. Molecules 19:686-698.
11. Chen Y, Zhao YH, Jia XB, and Hu M (2008) Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharm Res 25:2190-2199.
12. Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, Harris HMB, Coakley M, Lakshminarayanan B, and O'Sullivan O, et al. (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature 488:178-184.
13. Cui L, Sun E, Zhang Z, Qian Q, Tan X, Xu F, and Jia X (2013) Metabolite profiles of epimedin B in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J Agric Food Chem 61:3589-3599.
14. Dongmei C, Guofeng L, and Weilin P (2012) Serum cytosolic β-glucosidase levels in neonatal necrotizing enterocolitis. Iran J Pediatr 22:452-456.
15. Gao X, Chen Y, Wang Y, Sun WJ, and Jia XB (2013) [Study on different factors affecting the bionic enzymatic hydrolysis of icariin]. Yao Xue Xue Bao 48:1716-1721.
16. Higaki K, Sone M, Ogawara K, and Kimura T (2004) Regulation of drug absorption from small intestine by enteric nervous system I: a poorly absorbable drug via passive diffusion. Drug Metab Pharmacokinet 19:198-205.
17. Ishihara M, Homma M, Kuno E, Watanabe M, and Kohda Y (2002) [Combination use of kampomedicines and drugs affecting intestinal bacterial flora]. Yakugaku Zasshi 122:695-701.
18. Johnell O and Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726-1733.
19. Kanis JA, Melton LJ, 3rd, Christiansen C, Johnston CC, and Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141.
20. Koren O, Goodrich JK, Cullender TC, Spor A, Laitinen K, Bäckhed HK, Gonzalez A, Werner JJ, Angenent LT, and Knight R, et al. (2012) Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150:470-480.
21. Kulak CA, Borba VZ, Kulak Júnior J, and Custódio MR (2014) Bone disease after transplantation: osteoporosis and fractures risk. Arq Bras Endocrinol Metabol 58:484-492.
22. Liu Y and Hu M (2002) Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab Dispos 30:370-377.
23. Löscher W and Potschka H (2005) Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx 2:86-98.
24. Murphy EF, Cotter PD, Hogan A, O'Sullivan O, Joyce A, Fouhy F, Clarke SF, Marques TM, O'Toole PW, and Stanton C, et al. (2013) Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity. Gut 62:220-226.
25. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, and Allan JD (2002) Postmenopausal hormone replacement therapy: scientific review. JAMA 288:872-881.
26. Németh K, Plumb GW, Berrin JG, Juge N, Jacob R, Naim HY, Williamson G, Swallow DM, and Kroon PA (2003) Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr 42:29-42.
27. Qian Q, Li SL, Sun E, Zhang KR, Tan XB, Wei YJ, Fan HW, Cui L, and Jia XB (2012) Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry. J Pharm Biomed Anal 66:392-398.
28. Sekirov I, Russell SL, Antunes LCM, and Finlay BB (2010) Gut microbiota in health and disease. Physiol Rev 90:859-904.
29. Sesink AL, Arts IC, Faassen-Peters M, and Hollman PC (2003) Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase. J Nutr 133:773-776.
30. Shen J, Obin MS, and Zhao L (2013) The gut microbiota, obesity and insulin resistance. Mol Aspects Med 34:39-58.
31. Tseung CW, McMahon LG, Vázquez J, Pohl J, and Gregory JF, 3rd (2004) Partial amino acid sequence and mRNA analysis of cytosolic pyridoxine-beta-D-glucoside hydrolase from porcine intestinal mucosa: proposed derivation from the lactase-phlorizin hydrolase gene. Biochem J 380:211-218.
32. Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, Li D, Hou Z, Lv K, and Kan G, et al. (2013) miR-214 targets ATF4 to inhibit bone formation. Nat Med 19:93-100.
33. Wei Y, Li P, Fan H, Sun E, Wang C, Shu L, Liu W, Xue X, Qian Q, and Jia X (2012) Metabolite profiling of four major flavonoids of Herba Epimedii in zebrafish. Molecules 17:420-432.
34. Wu H, Lien EJ, and Lien LL (2003) Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res 60:1-57.
35. Xu YX, Xu B, Wu CL, Wu Y, Tong PJ, and Xiao LW (2011) Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariectomized rats. Orthop Surg 3:119-126.
36. Zhang G, Qin L, and Shi Y (2007) Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, doubleblind and placebo-controlled trial. J Bone Miner Res 22:1072-1079.
37. Zhao H, Fan M, Fan L, Sun J, and Guo D (2010) Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. J Chromatogr B Analyt Technol Biomed Life Sci 878:1113-1124.
38. Zhao XB, Wu WJ, Li DD, Li XY, Zhang HL, Tan ZJ, and Cai GX (2013) The effect of modeling spleen-deficiency constipation on the intestinal microbiota and enzyme activities in mice. Chinese J Microeco 25:993-996.
39. Zhou J, Chen Y, Wang Y, Gao X, Qu D, and Liu C (2013) A comparative study on the metabolism of Epimedium koreanum Nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora. Molecules 19:177-203.