Molecular mechanisms and timing of cortical immune activation in schizophrenia

American Journal of Psychiatry

Volumn 172, Issue 11, 2015, Pages 1052-1053

  Hyde, Thomas M ^a   Bharadwaj, Rahul A ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; C REACTIVE PROTEIN; HALOPERIDOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON INDUCED TRANSMEMBRANE PROTEIN; INTERLEUKIN 6; MEMBRANE PROTEIN; OLANZAPINE; UNCLASSIFIED DRUG; MESSENGER RNA;

AUTOIMMUNE DISEASE; DEVELOPMENT; DORSOLATERAL PREFRONTAL CORTEX; EDITORIAL; GENE; GENE CLUSTER; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LINKAGE DISEQUILIBRIUM; GENE OVEREXPRESSION; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; GENETIC VARIABILITY; GRAY MATTER; HEPATITIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IFITM GENE; IMMUNE SYSTEM; IMMUNOGENICITY; IMMUNOREACTIVITY; INFECTION; INFLUENZA; LONG TERM CARE; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX I; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NFKB GENE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; FEMALE; IMMUNOLOGY; MALE; PREGNANCY;

ANIMALS; FEMALE; HUMANS; MALE; PREFRONTAL CORTEX; PREGNANCY; RNA, MESSENGER; SCHIZOPHRENIA;

EID: 84946142298     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2015.15091187     Document Type: Editorial

References (13)

1. Kim S, Hwang Y, Webster MJ, et al: Differential activation of immune/inflammatory response-related co-expression modules in the hippocampus across the major psychiatric disorders. Mol Psychiatry (Epub ahead of print, June 16, 2015)
2. Siegel BI, Sengupta EJ, Edelson JR, et al: Elevated viral restriction factor levels in cortical blood vessels in schizophrenia. Biol Psychiatry 2014;76:160-167
3. Volk DW, Chitrapu A, Edelson JR, et al: Molecular mechanisms and timing of cortical immune activation in schizophrenia. Am J Psychiatry 2015;172:1112-1121
4. Bailey CC, Zhong G, Huang IC, et al: IFITM-family proteins: the cell's first line of antiviral defense. Annu Rev Virol 2014;1:261-283
5. Elmer BM, McAllister AK: Major histocompatibility complex class I proteins in brain development and plasticity. Trends Neurosci 2012;35:660-670
6. Chen ML, Tsai TC, Lin YY, et al: Antipsychotic drugs suppress the AKT/NF-kB pathway and regulate the differentiation of T-cell subsets. Immunol Lett 2011;140:81-91
7. Stefansson H, Ophoff RA, Steinberg S, et al: Common variants conferring risk of schizophrenia. Nature 2009;460:744-747
8. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium: Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011;43:969-976
9. Horváth S, Mirnics K: Schizophrenia as a disorder of molecular pathways. Biol Psychiatry 2015;77:22-28
10. Walters JT, Rujescu D, Franke B, et al: The role of the major histocompatibility complex region in cognition and brain structure: a schizophreniaGWASfollow-up. AmJ Psychiatry 2013;170:877-885
11. Benros MF, Nielsen PR, Nordentoft M, et al: Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study. AmJ Psychiatry 2011;168:1303-1310
12. Clarke MC, Tanskanen A, Huttunen M, et al: Evidence for an interaction between familial liabilityand prenatal exposure to infection in the causation of schizophrenia. Am J Psychiatry 2009;166:1025-1030
13. Canetta S, Sourander A, Surcel H-M, et al: Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort. Am J Psychiatry 2014;171:960-968