Characterization of CD4/CD8+ αβ and Vγ2Vδ2+ T cells in HIV-negative individuals with different Mycobacterium tuberculosis infection statuses

Human Immunology

Volumn 76, Issue 11, 2015, Pages 801-807

  Gao, Yan ^a   Zhang, Shu ^a   Ou, Qinfang ^b   Shen, Lei ^a   Wang, Sen ^a   Wu, Jing ^a   Weng, Xinhua ^a   Chen, Zheng W ^c   Zhang, Wenhong ^a   Shao, Lingyun ^a  

^a FUDAN UNIVERSITY   (China)

^b Wuxi No 5 People's Hospital   (China)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Active tuberculosis; Immune response; Interferon gamma; Latent tuberculosis infection; T cell subsets

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; BACTERIAL ANTIGEN; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LATENT TUBERCULOSIS; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PLEURA BIOPSY; PLEURA FLUID; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TUBERCULOSIS; TUBERCULOUS PLEURISY; AGED; IMMUNOLOGY; IMMUNOPHENOTYPING; INTERFERON GAMMA RELEASE ASSAY; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERFERON-GAMMA RELEASE TESTS; LATENT TUBERCULOSIS; MALE; MIDDLE AGED; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; TUBERCULOSIS; YOUNG ADULT;

EID: 84946074749     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2015.09.039     Document Type: Article

References (33)

1. Nunn P., Williams B., Floyd K., Dye C., Elzinga G., Raviglione M. Tuberculosis control in the era of HIV. Nat. Rev. Immunol. 2005, 5:819-826.
2. Stenger S., Hanson D.A., Teitelbaum R., Dewan P., Niazi K.R., Froelich C.J., et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 1998, 282:121-125.
3. Ehlers S. Immunity to tuberculosis: a delicate balance between protection and pathology. FEMS Immunol. Med. Microbiol. 1999, 23:149-158.
4. Flynn J.L., Ernst J.D. Immune responses in tuberculosis. Curr. Opin. Immunol. 2000, 12:432-436.
5. Winslow G.M., Cooper A., Reiley W., Chatterjee M., Woodland D.L. Early T-cell responses in tuberculosis immunity. Immunol. Rev. 2008, 225:284-299.
6. Rueda C.M., Marin N.D., Garcia L.F., Rojas M. Characterization of CD4 and CD8 T cells producing IFN-gamma in human latent and active tuberculosis. Tuberculosis 2010, 90:346-353.
7. Stenger S., Modlin R.L. Cytotoxic T cell responses to intracellular pathogens. Curr. Opin. Immunol. 1998, 10:471-477.
8. Chen Z.W. Immune regulation of gammadelta T cell responses in mycobacterial infections. Clin. Immunol. 2005, 116:202-207.
9. Lazarevic V., Nolt D., Flynn J.L. Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses. J. Immunol. 2005, 175:1107-1117.
10. Chen Y., Shao L., Ali Z., Cai J., Chen Z.W. NSOM/QD-based nanoscale immunofluorescence imaging of antigen-specific T-cell receptor responses during an in vivo clonal Vgamma2Vdelta2 T-cell expansion. Blood 2008, 111:4220-4232.
11. Gong G., Shao L., Wang Y., Chen C.Y., Huang D., Yao S., et al. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Blood 2009, 113:837-845.
12. Yao S., Huang D., Chen C.Y., Halliday L., Zeng G., Wang R.C., et al. Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis. PLoS Pathog. 2010, 6:e1000789.
13. Ali Z., Shao L., Halliday L., Reichenberg A., Hintz M., Jomaa H., et al. Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques. J. Immunol. 2007, 179:8287-8296.
14. Shao L., Zhang W., Zhang S., Chen C.Y., Jiang W., Xu Y., et al. Potent immune responses of Ag-specific Vgamma2Vdelta2+ T cells and CD8+ T cells associated with latent stage of Mycobacterium tuberculosis coinfection in HIV-1-infected humans. Aids 2008, 22:2241-2250.
15. Mack U., Migliori G.B., Sester M., Rieder H.L., Ehlers S., Goletti D., et al. LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. Eur. Respir. J. 2009, 33:956-973.
16. van Crevel R., Ottenhoff T.H., van der Meer J.W. Innate immunity to Mycobacterium tuberculosis. Adv Exp Med Biol 2003, 531:241-247.
17. Schwander S., Dheda K. Human lung immunity against Mycobacterium tuberculosis: insights into pathogenesis and protection. Am. J. Respir. Crit. Care Med. 2011, 183:696-707.
18. Serbina N.V., Jia T., Hohl T.M., Pamer E.G. Monocyte-mediated defense against microbial pathogens. Annu. Rev. Immunol. 2008, 26:421-452.
19. Chen K., Kolls J.K. T cell-mediated host immune defenses in the lung. Annu. Rev. Immunol. 2013, 31:605-633.
20. Wu Y.E., Zhang S.W., Peng W.G., Li K.S., Li K., Jiang J.K., et al. Changes in lymphocyte subsets in the peripheral blood of patients with active pulmonary tuberculosis. J. Int. Med. Res. 2009, 37:1742-1749.
21. Henao-Tamayo M.I., Ordway D.J., Irwin S.M., Shang S., Shanley C., Orme I.M. Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis. Clin. Vaccine Immunol. CVI 2010, 17:618-625.
22. Chen C.Y., Huang D., Wang R.C., Shen L., Zeng G., Yao S., et al. A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. PLoS Pathog. 2009, 5:e1000392.
23. Yao S., Huang D., Chen C.Y., Halliday L., Wang R.C., Chen Z.W. CD4+ T cells contain early extrapulmonary tuberculosis (TB) dissemination and rapid TB progression and sustain multieffector functions of CD8+ T and CD3-lymphocytes: mechanisms of CD4+ T cell immunity. J. Immunol. 2014, 192:2120-2132.
24. Sauzullo I., Scrivo R., Mengoni F., Ermocida A., Coppola M., Valesini G., et al. Multi-functional flow cytometry analysis of CD4(+) T cells as an immune biomarker for latent tuberculosis status in patients treated with tumour necrosis factor (TNF) antagonists. Clin. Exp. Immunol. 2014, 176:410-417.
25. Prezzemolo T., Guggino G., La Manna M.P., Di Liberto D., Dieli F., Caccamo N. Functional signatures of human CD4 and CD8 T cell responses to Mycobacterium tuberculosis. Front. Immunol. 2014, 5:180.
26. Qiu Z., Zhang M., Zhu Y., Zheng F., Lu P., Liu H., et al. Multifunctional CD4 T cell responses in patients with active tuberculosis. Sci. Rep. 2012, 2:216.
27. Marin N.D., Paris S.C., Rojas M., Garcia L.F. Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB. Tuberculosis 2013, 93:155-166.
28. Yang J., He J., Huang H., Ji Z., Wei L., Ye P., et al. Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection. BMC Infect. Dis. 2013, 13:423.
29. Chen Z.W. Multifunctional immune responses of HMBPP-specific Vgamma2Vdelta2 T cells in M. tuberculosis and other infections. Cell. Mol. Immunol. 2013, 10:58-64.
30. Mitra D.K., Sharma S.K., Dinda A.K., Bindra M.S., Madan B., Ghosh B. Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitment. Eur. J. Immunol. 2005, 35:2367-2375.
31. Caramori G., Lasagna L., Casalini A.G., Adcock I.M., Casolari P., Contoli M., et al. Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy. PLoS ONE 2011, 6:e22637.
32. Li Q., Li L., Liu Y., Fu X., Wang H., Lao S., et al. Biological functions of Mycobacterium tuberculosis-specific CD4+T cells were impaired by tuberculosis pleural fluid. Immunol. Lett. 2011, 138:113-121.
33. Chen C.Y., Yao S., Huang D., Wei H., Sicard H., Zeng G., et al. Phosphoantigen/IL2 expansion and differentiation of Vgamma2Vdelta2 T cells increase resistance to tuberculosis in nonhuman primates. PLoS Pathog. 2013, 9:e1003501.