-
1
-
-
0019122409
-
Identification of somatomedin- like polypeptides produced by mammary tumors of BALB/c mice
-
Knauer DJ, Iyer AP, Banerjee MR, Smith GL. Identification of somatomedin- like polypeptides produced by mammary tumors of BALB/c mice. Cancer Res. 1980;40:4368–4372.
-
(1980)
Cancer Res
, vol.40
, pp. 4368-4372
-
-
Knauer, D.J.1
Iyer, A.P.2
Banerjee, M.R.3
Smith, G.L.4
-
2
-
-
0018864628
-
Interaction of somatomedin- C with an antibody directed against the synthetic C-peptide region of insulin-like growth factor-I
-
Hintz RL, Liu F, Marshall LB, Chang D. Interaction of somatomedin- C with an antibody directed against the synthetic C-peptide region of insulin-like growth factor-I. J Clin Endocrinol Metab. 1980;50:405–407.
-
(1980)
J Clin Endocrinol Metab
, vol.50
, pp. 405-407
-
-
Hintz, R.L.1
Liu, F.2
Marshall, L.B.3
Chang, D.4
-
3
-
-
0024460381
-
Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice
-
Arteaga CL, Kitten LJ, Coronado EB, et al. Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J Clin Invest. 1989;84:1418–1423.
-
(1989)
J Clin Invest
, vol.84
, pp. 1418-1423
-
-
Arteaga, C.L.1
Kitten, L.J.2
Coronado, E.B.3
-
4
-
-
0021718287
-
Receptor binding and growth-promoting activity of insulin-like growth factors in human breast cancer cells (T-47D) in culture
-
Myal Y, Shiu RP, Bhaumick B, Bala M. Receptor binding and growth-promoting activity of insulin-like growth factors in human breast cancer cells (T-47D) in culture. Cancer Res. 1984;44:5486–5490.
-
(1984)
Cancer Res
, vol.44
, pp. 5486-5490
-
-
Myal, Y.1
Shiu, R.P.2
Bhaumick, B.3
Bala, M.4
-
5
-
-
0024369203
-
Insulin-like growth factor-II (IGF-1I): A potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-1 receptor
-
Osborne CK, Coronado EB, Kitten LJ, et al. Insulin-like growth factor-II (IGF-1I): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-1 receptor. Mol Endocrinol. 1989;3:1701–1709.
-
(1989)
Mol Endocrinol
, vol.3
, pp. 1701-1709
-
-
Osborne, C.K.1
Coronado, E.B.2
Kitten, L.J.3
-
6
-
-
0034788985
-
The IGF system and breast cancer
-
Sachdev D, Yee D. The IGF system and breast cancer. Endocr Relat Cancer. 2001;8:197–209.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 197-209
-
-
Sachdev, D.1
Yee, D.2
-
7
-
-
57149139395
-
Regulation of breast cancer metastasis by IGF signaling
-
Sachdev D. Regulation of breast cancer metastasis by IGF signaling. J Mammary Gland Biol Neoplasia. 2008;13:431–441.
-
(2008)
J Mammary Gland Biol Neoplasia
, vol.13
, pp. 431-441
-
-
Sachdev, D.1
-
8
-
-
74449085460
-
The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival
-
Sachdev D, Zhang X, Matise I, Gaillard-Kelly M, Yee D. The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival. Oncogene. 2010;29:251–262.
-
(2010)
Oncogene
, vol.29
, pp. 251-262
-
-
Sachdev, D.1
Zhang, X.2
Matise, I.3
Gaillard-Kelly, M.4
Yee, D.5
-
9
-
-
84863722180
-
Transgenic IGF-1R overexpression induces mammary tumors with basal-like characteristics, whereas IGF-1R-independent mammary tumors express a claudin-low gene signature
-
Franks SE, Campbell CI, Barnett EF, et al. Transgenic IGF-1R overexpression induces mammary tumors with basal-like characteristics, whereas IGF-1R-independent mammary tumors express a claudin-low gene signature. Oncogene. 2012;31:3298–3309.
-
(2012)
Oncogene
, vol.31
, pp. 3298-3309
-
-
Franks, S.E.1
Campbell, C.I.2
Barnett, E.F.3
-
10
-
-
67349222877
-
Reversibility and recurrence of IGF-1R-induced mammary tumors
-
Jones RA, Campbell CI, Wood GA, Petrik JJ, Moorehead RA. Reversibility and recurrence of IGF-1R-induced mammary tumors. Oncogene. 2009;28:2152–2162.
-
(2009)
Oncogene
, vol.28
, pp. 2152-2162
-
-
Jones, R.A.1
Campbell, C.I.2
Wood, G.A.3
Petrik, J.J.4
Moorehead, R.A.5
-
11
-
-
0032499440
-
Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
-
Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998;351:1393–1396.
-
(1998)
Lancet
, vol.351
, pp. 1393-1396
-
-
Hankinson, S.E.1
Willett, W.C.2
Colditz, G.A.3
-
12
-
-
0006407985
-
Response: Re: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
-
Ma J, Giovannucci E, Pollak M, Stampfer M. Response: Re: prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst. 1999;91:2052.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 2052
-
-
Ma, J.1
Giovannucci, E.2
Pollak, M.3
Stampfer, M.4
-
13
-
-
0033585421
-
Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
-
Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X. Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst. 1999;91:151–156.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 151-156
-
-
Yu, H.1
Spitz, M.R.2
Mistry, J.3
Gu, J.4
Hong, W.K.5
Wu, X.6
-
14
-
-
84906313304
-
Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer
-
Vilmar A, Santoni-Rugiu E, Garcia-Foncillas J, Huarriz M, Sorensen JB. Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer. Anticancer Res. 2014;34:2991–2996.
-
(2014)
Anticancer Res
, vol.34
, pp. 2991-2996
-
-
Vilmar, A.1
Santoni-Rugiu, E.2
Garcia-Foncillas, J.3
Huarriz, M.4
Sorensen, J.B.5
-
15
-
-
84866423991
-
Contrasted outcomes to gefitinib on tumoral IGF1R expression in head and neck cancer patients receiving postoperative chemoradiation (GORTEC trial 2004–02)
-
Thariat J, Bensadoun RJ, Etienne-Grimaldi MC, et al. Contrasted outcomes to gefitinib on tumoral IGF1R expression in head and neck cancer patients receiving postoperative chemoradiation (GORTEC trial 2004–02). Clin Cancer Res. 2012;18:5123–5133.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5123-5133
-
-
Thariat, J.1
Bensadoun, R.J.2
Etienne-Grimaldi, M.C.3
-
16
-
-
49249125421
-
Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma
-
Lacy MQ, Alsina M, Fonseca R, et al. Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma. J Clin Oncol. 2008;26:3196–3203.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3196-3203
-
-
Lacy, M.Q.1
Alsina, M.2
Fonseca, R.3
-
17
-
-
35348815620
-
Phase I dose escalation study of the anti-insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors
-
Haluska P, Shaw HM, Batzel GN, et al. Phase I dose escalation study of the anti-insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res. 2007;13:5834–5840.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5834-5840
-
-
Haluska, P.1
Shaw, H.M.2
Batzel, G.N.3
-
18
-
-
75749102231
-
Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma
-
Haluska P, Worden F, Olmos D, et al. Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma. Cancer Chemother Pharmacol. 2010;65:765–773.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 765-773
-
-
Haluska, P.1
Worden, F.2
Olmos, D.3
-
19
-
-
75249097799
-
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing’s sarcoma: A phase 1 expansion cohort study
-
Olmos D, Postel-Vinay S, Molife LR, et al. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing’s sarcoma: a phase 1 expansion cohort study. Lancet Oncol. 2010;11: 129–135.
-
(2010)
Lancet Oncol
, vol.11
, pp. 129-135
-
-
Olmos, D.1
Postel-Vinay, S.2
Molife, L.R.3
-
20
-
-
70449556274
-
Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,871) in combination with paclitaxel and carboplatin
-
Karp DD, Pollak MN, Cohen RB, et al. Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,871) in combination with paclitaxel and carboplatin. J Thorac Oncol. 2009;4:1397–1403.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 1397-1403
-
-
Karp, D.D.1
Pollak, M.N.2
Cohen, R.B.3
-
21
-
-
66349091290
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP- 751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Karp DD, Paz-Ares LG, Novello S, et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP- 751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol. 2009;27:2516–2522.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
-
22
-
-
84870799125
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Retraction. “Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer.” J Clin Oncol. 2012;30: 4179.
-
(2012)
J Clin Oncol
, vol.30
, pp. 4179
-
-
-
23
-
-
73349099049
-
Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
-
Tolcher AW, Sarantopoulos J, Patnaik A, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol. 2009;27:5800–5807.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5800-5807
-
-
Tolcher, A.W.1
Sarantopoulos, J.2
Patnaik, A.3
-
24
-
-
84863908472
-
Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors
-
Tap WD, Demetri G, Barnette P, et al. Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors. J Clin Oncol. 2012;30:1849–1856.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1849-1856
-
-
Tap, W.D.1
Demetri, G.2
Barnette, P.3
-
25
-
-
80053525113
-
A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors
-
Atzori F, Tabernero J, Cervantes A, et al. A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res. 2011;17: 6304–6312.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6304-6312
-
-
Atzori, F.1
Tabernero, J.2
Cervantes, A.3
-
26
-
-
84920518981
-
Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: Preclinical characterization and phase I clinical trial
-
Di Cosimo S, Sathyanarayanan S, Bendell JC, et al. Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial. Clin Cancer Res. 2015;21:49–59.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 49-59
-
-
Di Cosimo, S.1
Sathyanarayanan, S.2
Bendell, J.C.3
-
27
-
-
84900841645
-
Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells
-
Weinstein D, Sarfstein R, Laron Z, Werner H. Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells. Endocr Connect. 2014;3:24–35.
-
(2014)
Endocr Connect
, vol.3
, pp. 24-35
-
-
Weinstein, D.1
Sarfstein, R.2
Laron, Z.3
Werner, H.4
-
28
-
-
77958067823
-
Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): Rationale for cotargeting IGF-1R and IR in cancer
-
Buck E, Gokhale PC, Koujak S, et al. Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer. Mol Cancer Ther. 2010;9:2652–2664.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2652-2664
-
-
Buck, E.1
Gokhale, P.C.2
Koujak, S.3
-
29
-
-
84923188816
-
A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors
-
Puzanov I, Lindsay CR, Goff L, et al. A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. Clin Cancer Res. 2015;21:701–711.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 701-711
-
-
Puzanov, I.1
Lindsay, C.R.2
Goff, L.3
-
30
-
-
84923203848
-
Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors
-
Jones RL, Kim ES, Nava-Parada P, et al. Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors. Clin Cancer Res. 2015;21:693–700.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 693-700
-
-
Jones, R.L.1
Kim, E.S.2
Nava-Parada, P.3
-
31
-
-
84905867935
-
Randomized, phase III trial of first-line figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin alone in patients with advanced non-small-cell lung cancer
-
Langer CJ, Novello S, Park K, et al. Randomized, phase III trial of first-line figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin alone in patients with advanced non-small-cell lung cancer. J Clin Oncol. 2014;32:2059–2066.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2059-2066
-
-
Langer, C.J.1
Novello, S.2
Park, K.3
-
32
-
-
84983102615
-
Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: A phase I/II randomized trial
-
Moran T, Felip E, Keedy V, et al. Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: a phase I/II randomized trial. Exp Hematol Oncol. 2014;3:26.
-
(2014)
Exp Hematol Oncol
, vol.3
, pp. 26
-
-
Moran, T.1
Felip, E.2
Keedy, V.3
-
33
-
-
84930946251
-
Randomized, phase III trial of figitumumab in combination with erlotinib versus erlotinib alone in patients with nonadenocarcinoma nonsmall-cell lung cancer
-
Scagliotti GV, Bondarenko I, Blackhall F, et al. Randomized, phase III trial of figitumumab in combination with erlotinib versus erlotinib alone in patients with nonadenocarcinoma nonsmall-cell lung cancer. Ann Oncol. 2015;26:497–504.
-
(2015)
Ann Oncol
, vol.26
, pp. 497-504
-
-
Scagliotti, G.V.1
Bondarenko, I.2
Blackhall, F.3
-
34
-
-
84929083437
-
A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: The GAMMA trial
-
Fuchs CS, Azevedo S, Okusaka T, et al. A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial. Ann Oncol. 2015;26:921–927.
-
(2015)
Ann Oncol
, vol.26
, pp. 921-927
-
-
Fuchs, C.S.1
Azevedo, S.2
Okusaka, T.3
-
35
-
-
84933522088
-
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: A double-blind, randomised, phase 3 study
-
Fassnacht M, Berruti A, Baudin E, et al. Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study. Lancet Oncol. 2015;16:426–435.
-
(2015)
Lancet Oncol
, vol.16
, pp. 426-435
-
-
Fassnacht, M.1
Berruti, A.2
Baudin, E.3
-
36
-
-
84919468696
-
Insulin-like growth factor 1 receptor and response to anti-IGF1R antibody therapy in osteosarcoma
-
Cao Y, Roth M, Piperdi S, et al. Insulin-like growth factor 1 receptor and response to anti-IGF1R antibody therapy in osteosarcoma. Plos One. 2014;9:9(8):e106249.
-
(2014)
Plos One
, vol.9
, Issue.9-8
-
-
Cao, Y.1
Roth, M.2
Piperdi, S.3
-
37
-
-
84881246665
-
Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor
-
McCaffery I, Tudor Y, Deng H, et al. Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor. Clin Cancer Res. 2013;19:4282–4289.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4282-4289
-
-
McCaffery, I.1
Tudor, Y.2
Deng, H.3
-
38
-
-
77956665243
-
Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition
-
Gualberto A, Dolled-Filhart M, Gustavson M, et al. Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition. Clin Cancer Res. 2010;16:4654–4665.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4654-4665
-
-
Gualberto, A.1
Dolled-Filhart, M.2
Gustavson, M.3
-
39
-
-
84890520797
-
Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor figitumumab (CP-751,871)
-
Pavlicek A, Lira ME, Lee NV, et al. Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor figitumumab (CP-751,871). Mol Cancer Ther. 2013;12:2929–2939.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 2929-2939
-
-
Pavlicek, A.1
Lira, M.E.2
Lee, N.V.3
-
40
-
-
84923385676
-
IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines
-
Huang F, Chang H, Greer A, et al. IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines. Mol Cancer Ther. 2015;14:620–630.
-
(2015)
Mol Cancer Ther
, vol.14
, pp. 620-630
-
-
Huang, F.1
Chang, H.2
Greer, A.3
-
41
-
-
77953973648
-
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
-
Ulanet DB, Ludwig DL, Kahn CR, Hanahan D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci USA. 2010;107:10791–10798.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 10791-10798
-
-
Ulanet, D.B.1
Ludwig, D.L.2
Kahn, C.R.3
Hanahan, D.4
-
42
-
-
84863900275
-
Insulin-like growth factor receptor inhibitors: Baby or the bathwater?
-
Yee D. Insulin-like growth factor receptor inhibitors: baby or the bathwater? J Natl Cancer Inst. 2012;104:975–981.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 975-981
-
-
Yee, D.1
-
43
-
-
77951879658
-
Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation
-
Zhang H, Fagan DH, Zeng X, Freeman KT, Sachdev D, Yee D. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene. 2010;29:2517–2527.
-
(2010)
Oncogene
, vol.29
, pp. 2517-2527
-
-
Zhang, H.1
Fagan, D.H.2
Zeng, X.3
Freeman, K.T.4
Sachdev, D.5
Yee, D.6
-
44
-
-
84863584930
-
Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: Implications for breast cancer treatment
-
Fagan DH, Uselman RR, Sachdev D, Yee D. Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment. Cancer Res. 2012;72:3372–3380.
-
(2012)
Cancer Res
, vol.72
, pp. 3372-3380
-
-
Fagan, D.H.1
Uselman, R.R.2
Sachdev, D.3
Yee, D.4
-
45
-
-
84890191760
-
Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-1 receptor
-
Gallagher EJ, Alikhani N, Tobin-Hess A, et al. Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-1 receptor. Diabetes. 2013;62:3553–3560.
-
(2013)
Diabetes
, vol.62
, pp. 3553-3560
-
-
Gallagher, E.J.1
Alikhani, N.2
Tobin-Hess, A.3
-
46
-
-
84929379391
-
Growth hormone enhances LNCaP prostate cancer cell motility
-
Nakonechnaya AO, Shewchuk BM. Growth hormone enhances LNCaP prostate cancer cell motility. Endocr Res. 2015;40(2):97–105.
-
(2015)
Endocr Res
, vol.40
, Issue.2
, pp. 97-105
-
-
Nakonechnaya, A.O.1
Shewchuk, B.M.2
-
47
-
-
79951938474
-
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
-
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011;3:70ra13.
-
(2011)
Sci Transl Med
, vol.3
-
-
Guevara-Aguirre, J.1
Balasubramanian, P.2
Guevara-Aguirre, M.3
-
48
-
-
84916212572
-
Obesity, diabetes and cancer: Insight into the relationship from a cohort with growth hormone receptor deficiency
-
Guevara-Aguirre J, Rosenbloom AL. Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency. Diabetologia. 2015;58:37–42.
-
(2015)
Diabetologia
, vol.58
, pp. 37-42
-
-
Guevara-Aguirre, J.1
Rosenbloom, A.L.2
-
49
-
-
84883156145
-
Growth hormone potentiates 17β-estradiol-dependent breast cancer cell proliferation independently of IGF-1 receptor signaling
-
Felice DL, El-Shennawy L, Zhao S, et al. Growth hormone potentiates 17β-estradiol-dependent breast cancer cell proliferation independently of IGF-1 receptor signaling. Endocrinology. 2013;154: 3219–3227.
-
(2013)
Endocrinology
, vol.154
, pp. 3219-3227
-
-
Felice, D.L.1
El-Shennawy, L.2
Zhao, S.3
-
50
-
-
84895779092
-
Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis
-
Schmidt JW, Wehde BL, Sakamoto K, et al. Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol. 2014;34: 1363–1377.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 1363-1377
-
-
Schmidt, J.W.1
Wehde, B.L.2
Sakamoto, K.3
-
51
-
-
84897898210
-
IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice
-
Moody G, Beltran PJ, Mitchell P, et al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014;221:145–155.
-
(2014)
J Endocrinol
, vol.221
, pp. 145-155
-
-
Moody, G.1
Beltran, P.J.2
Mitchell, P.3
-
52
-
-
65249171425
-
Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects
-
Moller N, Jorgensen JO. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009;30:152–177.
-
(2009)
Endocr Rev
, vol.30
, pp. 152-177
-
-
Moller, N.1
Jorgensen, J.O.2
-
53
-
-
58249101005
-
The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
-
Huang F, Greer A, Hurlburt W, et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res. 2009;69:161–170.
-
(2009)
Cancer Res
, vol.69
, pp. 161-170
-
-
Huang, F.1
Greer, A.2
Hurlburt, W.3
-
54
-
-
34547107855
-
Insulin- like growth factor receptor as a therapeutic target in head and neck cancer
-
Barnes CJ, Ohshiro K, Rayala SK, El-Naggar AK, Kumar R. Insulin- like growth factor receptor as a therapeutic target in head and neck cancer. Clin Cancer Res. 2007;13:4291–4299.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4291-4299
-
-
Barnes, C.J.1
Ohshiro, K.2
Rayala, S.K.3
El-Naggar, A.K.4
Kumar, R.5
-
55
-
-
47549108868
-
Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: Implication for gefitinib (’Iressa’) response and resistance
-
Knowlden JM, Jones HE, Barrow D, Gee JM, Nicholson RI, Hutcheson IR. Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for gefitinib (’Iressa’) response and resistance. Breast Cancer Res Treat. 2008;111:79–91.
-
(2008)
Breast Cancer Res Treat
, vol.111
, pp. 79-91
-
-
Knowlden, J.M.1
Jones, H.E.2
Barrow, D.3
Gee, J.M.4
Nicholson, R.I.5
Hutcheson, I.R.6
-
56
-
-
46349092797
-
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
-
Cappuzzo F, Varella-Garcia M, Finocchiaro G, et al. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br J Cancer. 2008;99:83–89.
-
(2008)
Br J Cancer
, vol.99
, pp. 83-89
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Finocchiaro, G.3
-
57
-
-
65549158055
-
High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter diseasefree survival in resected non-small-cell lung cancer patients
-
Ludovini V, Bellezza G, Pistola L, et al. High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter diseasefree survival in resected non-small-cell lung cancer patients. Ann Oncol. 2009;20:842–849.
-
(2009)
Ann Oncol
, vol.20
, pp. 842-849
-
-
Ludovini, V.1
Bellezza, G.2
Pistola, L.3
-
58
-
-
33750453743
-
Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells
-
Byron SA, Horwitz KB, Richer JK, Lange CA, Zhang X, Yee D. Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. Br J Cancer. 2006;95:1220–1228.
-
(2006)
Br J Cancer
, vol.95
, pp. 1220-1228
-
-
Byron, S.A.1
Horwitz, K.B.2
Richer, J.K.3
Lange, C.A.4
Zhang, X.5
Yee, D.6
-
59
-
-
67649628084
-
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
-
Mukohara T, Shimada H, Ogasawara N, et al. Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression. Cancer Lett. 2009;282:14–24.
-
(2009)
Cancer Lett
, vol.282
, pp. 14-24
-
-
Mukohara, T.1
Shimada, H.2
Ogasawara, N.3
-
60
-
-
84908363886
-
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer
-
Lovly CM, McDonald NT, Chen H, et al. Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer. Nat Med. 2014;20(9):1027–1034.
-
(2014)
Nat Med
, vol.20
, Issue.9
, pp. 1027-1034
-
-
Lovly, C.M.1
McDonald, N.T.2
Chen, H.3
-
61
-
-
0030827881
-
Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin- 4, oncostatin M, and the interferons
-
Burfoot MS, Rogers NC, Watling D, et al. Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin- 4, oncostatin M, and the interferons. J Biol Chem. 1997;272: 24183–24190.
-
(1997)
J Biol Chem
, vol.272
, pp. 24183-24190
-
-
Burfoot, M.S.1
Rogers, N.C.2
Watling, D.3
-
62
-
-
80053174807
-
Barrow D, et al. ErbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines
-
Knowlden JM, Gee JM, Barrow D, et al. erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines. Breast Cancer Res. 2011;13:R93.
-
(2011)
Breast Cancer Res
, vol.13
, pp. R93
-
-
Knowlden, J.M.1
Gee, J.M.2
-
63
-
-
84896867375
-
Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer
-
Arnedos M, Drury S, Afentakis M, et al. Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer. Ann Oncol. 2014; 25:605–610.
-
(2014)
Ann Oncol
, vol.25
, pp. 605-610
-
-
Arnedos, M.1
Drury, S.2
Afentakis, M.3
-
64
-
-
84880889612
-
Therapeutic destruction of insulin receptor substrates for cancer treatment
-
Reuveni H, Flashner-Abramson E, Steiner L, et al. Therapeutic destruction of insulin receptor substrates for cancer treatment. Cancer Res. 2013;73:4383–4394.
-
(2013)
Cancer Res
, vol.73
, pp. 4383-4394
-
-
Reuveni, H.1
Flashner-Abramson, E.2
Steiner, L.3
-
65
-
-
84918594975
-
The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer
-
Ibuki N, Ghaffari M, Reuveni H, et al. The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014;13:2827–2839.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2827-2839
-
-
Ibuki, N.1
Ghaffari, M.2
Reuveni, H.3
-
66
-
-
80054921787
-
Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment
-
Drury SC, Detre S, Leary A, et al. Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment. Endocr Relat Cancer. 2011;18:565–577.
-
(2011)
Endocr Relat Cancer
, vol.18
, pp. 565-577
-
-
Drury, S.C.1
Detre, S.2
Leary, A.3
-
67
-
-
84926126979
-
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous endjoining and homologous recombination
-
Chitnis MM, Lodhia KA, Aleksic T, Gao S, Protheroe AS, Macaulay VM. IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous endjoining and homologous recombination. Oncogene. 2014;33: 5262–5273.
-
(2014)
Oncogene
, vol.33
, pp. 5262-5273
-
-
Chitnis, M.M.1
Lodhia, K.A.2
Aleksic, T.3
Gao, S.4
Protheroe, A.S.5
Macaulay, V.M.6
-
68
-
-
65249162840
-
Sequencing of type I insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo
-
Zeng X, Sachdev D, Zhang H, Gaillard-Kelly M, Yee D. Sequencing of type I insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo. Clin Cancer Res. 2009; 15:2840–2849.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2840-2849
-
-
Zeng, X.1
Sachdev, D.2
Zhang, H.3
Gaillard-Kelly, M.4
Yee, D.5
-
69
-
-
84941678069
-
The neoadjuvant model is still the future for drug development in breast cancer
-
DeMichele A, Yee D, Berry DA, et al. The neoadjuvant model is still the future for drug development in breast cancer. Clin Cancer Res. 2015;21(13):2911–2915.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.13
, pp. 2911-2915
-
-
Demichele, A.1
Yee, D.2
Berry, D.A.3
-
70
-
-
84859372038
-
Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study
-
Diabetes Prevention Program Research Group. Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes Care. 2012; 35:731–737.
-
(2012)
Diabetes Care
, vol.35
, pp. 731-737
-
-
|