Serum thyroglobulin before and after iodization of salt: An 11-year DanThyr follow-up study

European Journal of Endocrinology

Volumn 173, Issue 5, 2015, Pages 573-581

  Krejbjerg, Anne ^a   Bjergved, Lena ^b,c   Pedersen, Inge Bülow ^a   Carlé, Allan ^a,d   Knudsen, Nils ^c   Perrild, Hans ^c   Ovesen, Lars ^e   Rasmussen, Lone Banke ^f   Laurberg, Peter ^a  

^a AALBORG UNIVERSITY   (Denmark)

^b Research Centre for Prevention and Health   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

^d SILKEBORG REGIONAL HOSPITAL   (Denmark)

^e SLAGELSE HOSPITAL   (Denmark)

^f TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE; THYROGLOBULIN; SALT INTAKE;

ADULT; AGED; ARTICLE; DENMARK; DIET SUPPLEMENTATION; FEMALE; FOLLOW UP; GOITER; HUMAN; IMMUNORADIOMETRIC ASSAY; LONGITUDINAL STUDY; MALE; NUTRITIONAL STATUS; PRIORITY JOURNAL; SALT INTAKE; THYROGLOBULIN BLOOD LEVEL; ADOLESCENT; BLOOD; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; DENMARK; FEMALE; FOLLOW-UP STUDIES; FOOD, FORTIFIED; HUMANS; IODINE; MALE; MIDDLE AGED; SODIUM CHLORIDE, DIETARY; THYROGLOBULIN; YOUNG ADULT;

EID: 84946018404     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-15-0339     Document Type: Article

References (32)

1. Delange F. The disorders induced by iodine deficiency. Thyroid 1994 4 107-128. (doi:10.1089/thy.1994.4.107)
2. Zimmermann MB, Jooste PL & Pandav CS. Iodine-deficiency disorders. Lancet 2008 372 1251-1262. (doi:10.1016/S0140-6736(08)61005-3)
3. Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S, Pedersen IB & Carle A. Iodine intake as a determinant of thyroid disorders inpopulations.Best Practice&Research. Clinical Endocrinology&Metabolism 2010 24 13-27. (doi:10.1016/j.beem.2009.08.013)
4. Kelly FC & Snedden WW. Prevalence and distribution of endemic goitre. In Endemic Goitre, pp 27-233. Geneva, Switzerland: WHO, 1960.
5. Carle A, Krejbjerg A & Laurberg P. Epidemiology of nodular goitre. Influence of iodine intake. Best Practice & Research. Clinical Endocrinology & Metabolism 2014 28 465-479. (doi:10.1016/j.beem.2014.01.001)
6. Lamas L & Taurog A. The importance of thyroglobulin structure in thyroid peroxidase-catalyzed conversion of diiodotyrosine to thyrox-ine. Endocrinology1977 100 1129-1136. (doi:10.1210/endo-100-4-1129)
7. Daniel PM, Pratt OE, Roitt IM & Torrigiani G. The release of thyroglobulin from the thyroid gland into thyroid lymphatics; the identification of thyroglobulin in the thyroid lymph and in the blood of monkeys by physical and immunological methods and its estimation by radioimmunoassay. Immunology 1967 12 489-504.
8. Roitt IM & Torrigiani G. Identification and estimation of undegraded thyroglobulin in human serum. Endocrinology 1967 81 421-429. (doi:10.1210/endo-81-3-421)
9. Uller RP, Van Herle AJ & Chopra IJ. Comparison of alterations in circulating thyroglobulin, triiodothyronine and thyroxine in response to exogenous (bovine) and endogenous (human) thyrotropin. Journal of Clinical Endocrinology and Metabolism 1973 37 741-745. (doi:10.1210/jcem-37-5-741)
10. Van Herle AJ, Hershman JM, Hornabrook RW & Chopra IJ. Serum thyroglobulin in inhabitants of an endemic goiter region of New Guinea. Journal of Clinical Endocrinology and Metabolism 1976 43 512-516. (doi:10.1210/jcem-43-3-512)
11. Fenzi GF, Ceccarelli C, Macchia E, Monzani F, Bartalena L, Giani C, Ceccarelli P, Lippi F, Baschieri L & Pinchera A. Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area. Clinical Endocrinology 1985 23 115-122. (doi:10.1111/j.1365-2265. 1985.tb00205.x)
12. Laurberg P & Pedersen KM. A sensitive radio-immunoassay for serum thyroglobulin-including a correct screening for thyroglobulin autoantibodies. Scandinavian Journal of Clinical and Laboratory Investigation 1987 47 685-689. (doi:10.3109/00365518709168930)
13. Gutekunst R, Smolarek H, Hasenpusch U, Stubbe P, Friedrich HJ, Wood WG & Scriba PC. Goitre epidemiology: thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden. Acta Endocrinologica 1986 112 494-501.
14. Pedersen KM, Borlum KG, Knudsen PR, Hansen ES, Johannesen PL & Laurberg P. Urinary iodine excretion islow and serum thyroglobulin high in pregnant women in parts of Denmark. Acta Obstetricia et Gynecologica Scandinavica 1988 67 413-416. (doi:10.3109/00016348809004251)
15. Pedersen KM, Laurberg P, Iversen E, Knudsen PR, Gregersen HE, Rasmussen OS, Larsen KR, Eriksen GM & Johannesen PL. Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation. Journal of Clinical Endocrinology and Metabolism 1993 77 1078-1083.
16. Kahaly G, Dienes HP, Beyer J & Hommel G. Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter. Journal of Clinical Endocrinology and Metabolism 1997 82 4049-4053. (doi:10.1210/jcem.82.12.4416)
17. Laurberg P, Pedersen KM, Hreidarsson A, Sigfusson N, Iversen E & Knudsen PR. Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. Journal of Clinical Endocrinology and Metabolism 1998 83 765-769. (doi:10.1210/jcem.83.3.4624)
18. Knudsen N, Bulow I, Jorgensen T, Perrild H, Ovesen L & Laurberg P. Serum Tg-a sensitive marker of thyroid abnormalities and iodine deficiency in epidemiological studies. Journal of Clinical Endocrinology and Metabolism 2001 86 3599-3603.
19. Rasmussen LB, Ovesen L, Bulow I, Jorgensen T, Knudsen N, Laurberg P & Perrild H. Relations between various measures of iodine intake and thyroid volume, thyroid nodularity, and serum thyroglobulin. American Journal of Clinical Nutrition 2002 76 1069-1076.
20. Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Yu X, Fan C, Chong W et al. Effect of iodine intake on thyroid diseases in China. New England Journal of Medicine 2006 354 2783-2793. (doi:10.1056/NEJMoa054022)
21. Vejbjerg P, Knudsen N, Perrild H, Laurberg P, Carle A, Pedersen IB, Rasmussen LB, Ovesen L & Jorgensen T. Thyroglobulin as a marker of iodine nutrition status in the general population. European Journal of Endocrinology/European Federation of Endocrine Societies 2009 161 475-481. (doi:10.1530/EJE-09-0262)
22. Laurberg P, Jorgensen T, Perrild H, Ovesen L, Knudsen N, Pedersen IB, Rasmussen LB, Carle A & Vejbjerg P. The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives. European Journal of Endocrinology/European Federation of Endocrine Societies 2006 155 219-228. (doi:10.1530/eje.1.02210)
23. WHO, UNICEF, ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination. 3rd edn. Geneva: World Health Organization, 2007.
24. Rasmussen LB, Jorgensen T, Perrild H, Knudsen N, Krejbjerg A, Laurberg P, Pedersen IB, Bjergved L & Ovesen L. Mandatory iodine fortification of bread and salt increases iodine excretion in adults in Denmark-a 11-year follow-up study. Clinical Nutrition 2014 33 1033-1040. (doi:10.1016/j.clnu.2013.10.024)
25. Krejbjerg A, Bjergved L, Pedersen IB, Carle A, Jorgensen T, Perrild H, Ovesen L, Rasmussen LB, Knudsen N & Laurberg P. Iodine fortification may influence the age-related change in thyroid volume: a longitudinal population-based study (DanThyr). European Journal of Endocrinology/European Federation of Endocrine Societies 2014 170 507-517. (doi:10.1530/EJE-13-0918)
26. Wilson B & Van Zyl A. The estimation of iodine in thyroidal amino acids by alkaline ashing. South African Journal ofMedical Sciences 1967 32 70-82.
27. Laurberg P. Thyroxine and 3, 5, 3-triiodothyronine content of thyroglobulin in thyroid needle aspirates in hyperthyroidism and hypothyroidism. Journal of Clinical Endocrinology and Metabolism 1987 64 969-974. (doi:10.1210/jcem-64-5-969)
28. Zimmermann MB, Aeberli I, Andersson M, Assey V, Yorg JA, Jooste P, Jukic T, Kartono D, Kusic Z, Pretell E et al. Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 mg/l: a UNICEF/ICCIDD study group report. Journal of Clinical Endocrinology and Metabolism 2013 98 1271-1280. (doi:10.1210/jc. 2012-3952)
29. Ma ZF & Skeaff SA. Thyroglobulin as a biomarker of iodine deficiency: a review. Thyroid 2014 24 1195-1209. (doi:10.1089/thy.2014.0052)
30. Spencer CA & Wang CC. Thyroglobulin measurement. Techniques, clinical benefits, and pitfalls. Endocrinology and Metabolism Clinics of North America 1995 24 841-863.
31. Rasmussen LB, Carle A, Jorgensen T, Knuthsen P, Krejbjerg A, Perrild H, Bjergved L, Sloth JJ, Laurberg P & Ovesen L. Iodine excretion has decreased in Denmark between 2004 and 2010-the importance of iodine content in milk. British Journal of Nutrition 2014 112 1993-2001. (doi:10.1017/S0007114514003225)
32. Pedersen KM, Laurberg P, Nohr S, Jorgensen A & Andersen S. Iodine in drinking water varies by more than 100-fold in Denmark. Importance for iodine content of infant formulas. European Journal of Endocrinology/European Federation of Endocrine Societies 1999 140 400-403. (doi:10. 1530/eje.0.1400400)