-
3
-
-
84878232047
-
Management of adjuvant mitotane therapy following resection of adrenal cancer
-
Terzolo M, Ardito A, Zaggia B, et al. Management of adjuvant mitotane therapy following resection of adrenal cancer. Endocrine. 2012;42:521-525.
-
(2012)
Endocrine.
, vol.42
, pp. 521-525
-
-
Terzolo, M.1
Ardito, A.2
Zaggia, B.3
-
4
-
-
0000500594
-
Regression of adrenal cancer and suppression of adrenal function in men by o, p-DDD
-
Bergenstal D, Lipsett M, Moy R, Hertz R. Regression of adrenal cancer and suppression of adrenal function in men by o, p-DDD. Trans Am Physicians. 1959;72:341.
-
(1959)
Trans Am Physicians.
, vol.72
, pp. 341
-
-
Bergenstal, D.1
Lipsett, M.2
Moy, R.3
Hertz, R.4
-
5
-
-
84861888600
-
Combination chemotherapy in advanced adrenocortical carcinoma
-
Fassnacht M, Terzolo M, Allolio B, et al. Combination chemotherapy in advanced adrenocortical carcinoma. N Engl J Med. 2012; 366:2189-2197.
-
(2012)
N Engl J Med.
, vol.366
, pp. 2189-2197
-
-
Fassnacht, M.1
Terzolo, M.2
Allolio, B.3
-
6
-
-
34249999500
-
Adjuvant mitotane treatment for adrenocortical carcinoma
-
Terzolo M, Angeli A, Fassnacht M, et al. Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med. 2007;356:2372-2380.
-
(2007)
N Engl J Med.
, vol.356
, pp. 2372-2380
-
-
Terzolo, M.1
Angeli, A.2
Fassnacht, M.3
-
7
-
-
53749104093
-
Adjuvant mitotane for adrenocortical cancer-A recurring controversy
-
Huang H, Fojo T. Adjuvant mitotane for adrenocortical cancer-A recurring controversy. J Clin Endocrinol Metab. 2008;93:3730-3732.
-
(2008)
J Clin Endocrinol Metab.
, vol.93
, pp. 3730-3732
-
-
Huang, H.1
Fojo, T.2
-
8
-
-
79956306619
-
Plasma concentrations of o, p'DDD, o, p'DDA, and o, p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: Results of a retrospective ENS@T multicenter study
-
Hermsen IG, Fassnacht M, Terzolo M, et al. Plasma concentrations of o, p'DDD, o, p'DDA, and o, p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: Results of a retrospective ENS@T multicenter study. J Clin Endocrinol Metab. 2011; 96:1844-1851.
-
(2011)
J Clin Endocrinol Metab.
, vol.96
, pp. 1844-1851
-
-
Hermsen, I.G.1
Fassnacht, M.2
Terzolo, M.3
-
9
-
-
80054769146
-
Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma
-
Kroiss M, Quinkler M, Lutz WK, Allolio B, Fassnacht M. Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma. Clin Endocrinol (Oxf). 2011;75:585-591.
-
(2011)
Clin Endocrinol (Oxf).
, vol.75
, pp. 585-591
-
-
Kroiss, M.1
Quinkler, M.2
Lutz, W.K.3
Allolio, B.4
Fassnacht, M.5
-
10
-
-
84872085592
-
Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5a-reductase, explaining the need for personalized glucocorticoid and androgen replacement
-
Chortis V, Taylor AE, Schneider P, et al. Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5a-reductase, explaining the need for personalized glucocorticoid and androgen replacement. J Clin Endocrinol Metab. 2013;98:161-171.
-
(2013)
J Clin Endocrinol Metab.
, vol.98
, pp. 161-171
-
-
Chortis, V.1
Taylor, A.E.2
Schneider, P.3
-
11
-
-
0028835988
-
Metabolic activation and binding of mitotane in adrenal cortex homogenates
-
Cai W, Counsell RE, Djanegara T, Schteingart DE, Sinsheimer JE, Wotring LL. Metabolic activation and binding of mitotane in adrenal cortex homogenates. J Pharm Sci. 1995;84:134-138.
-
(1995)
J Pharm Sci.
, vol.84
, pp. 134-138
-
-
Cai, W.1
Counsell, R.E.2
Djanegara, T.3
Schteingart, D.E.4
Sinsheimer, J.E.5
Wotring, L.L.6
-
12
-
-
84879479863
-
Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells
-
Hescot S, Slama A, Lombès A, et al. Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells. Endocr Relat Cancer. 2013;20:371-381.
-
(2013)
Endocr Relat Cancer.
, vol.20
, pp. 371-381
-
-
Hescot, S.1
Slama, A.2
Lombès, A.3
-
13
-
-
84882753864
-
Morpho-functional effects of mitotane on mitochondria in human adrenocortical cancer cells
-
Poli G, Guasti D, Rapizzi E, et al. Morpho-functional effects of mitotane on mitochondria in human adrenocortical cancer cells. Endocr Relat Cancer. 2013;20:537-550.
-
(2013)
Endocr Relat Cancer.
, vol.20
, pp. 537-550
-
-
Poli, G.1
Guasti, D.2
Rapizzi, E.3
-
14
-
-
84866340964
-
Effects of mitotane on gene expression in the adrenocortical cell line NCI-H295R: A microarray study
-
Zsippai A, Szabó DR, Tömböl Z, et al. Effects of mitotane on gene expression in the adrenocortical cell line NCI-H295R: A microarray study. Pharmacogenomics. 2012;13:1351-1361.
-
(2012)
Pharmacogenomics.
, vol.13
, pp. 1351-1361
-
-
Zsippai, A.1
Szabó, D.R.2
Tömböl, Z.3
-
15
-
-
41349105275
-
Modulation of proteomic profile in H295R adrenocortical cell line induced by mitotane
-
Stigliano A, Cerquetti L, Borro M, et al. Modulation of proteomic profile in H295R adrenocortical cell line induced by mitotane. Endocr Relat Cancer. 2008;15:1-10.
-
(2008)
Endocr Relat Cancer.
, vol.15
, pp. 1-10
-
-
Stigliano, A.1
Cerquetti, L.2
Borro, M.3
-
16
-
-
84867254773
-
Sunitinib inhibits cell proliferation and alters steroidogenesis by down-regulation of HSD3B2 in adrenocortical carcinoma cells
-
Kroiss M, Reuss M, Kühner D, et al. Sunitinib inhibits cell proliferation and alters steroidogenesis by down-regulation of HSD3B2 in adrenocortical carcinoma cells. Front Endocrinol (Lausanne). 2011;2:27.
-
(2011)
Front Endocrinol (Lausanne).
, vol.2
, pp. 27
-
-
Kroiss, M.1
Reuss, M.2
Kühner, D.3
-
17
-
-
84868143898
-
Gas chromatography-tan-dem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors
-
Matysik S, Klünemann HH, Schmitz G. Gas chromatography-tan-dem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. Clin Chem. 2012;58:1557-1564.
-
(2012)
Clin Chem.
, vol.58
, pp. 1557-1564
-
-
Matysik, S.1
Klünemann, H.H.2
Schmitz, G.3
-
18
-
-
84860589540
-
Liebisch G A rapid GC-MS method for quantification of positional and geometric isomers of fatty acid methyl esters
-
Ecker J, Scherer M, Schmitz G, Liebisch G A rapid GC-MS method for quantification of positional and geometric isomers of fatty acid methyl esters. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;897:98-104.
-
(2012)
J Chromatogr B Analyt Technol Biomed Life Sci.
, vol.897
, pp. 98-104
-
-
Ecker, J.1
Scherer, M.2
Schmitz, G.3
-
19
-
-
33646048311
-
High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
-
Liebisch G, Binder M, Schifferer R, Langmann T, Schulz B, Schmitz G. High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS). Biochim Biophys Acta. 2006;1761:121-128.
-
(2006)
Biochim Biophys Acta.
, vol.1761
, pp. 121-128
-
-
Liebisch, G.1
Binder, M.2
Schifferer, R.3
Langmann, T.4
Schulz, B.5
Schmitz, G.6
-
20
-
-
0024389312
-
CL 277, 082: A novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption
-
Largis EE, Wang CH, DeVries VG, Schaffer SA. CL 277, 082: A novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989;30:681-690.
-
(1989)
J Lipid Res.
, vol.30
, pp. 681-690
-
-
Largis, E.E.1
Wang, C.H.2
DeVries, V.G.3
Schaffer, S.A.4
-
21
-
-
1242274634
-
Identification of ACAT1-And ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: Individual ACAT uniqueness
-
Lada AT, Davis M, Kent C, et al. Identification of ACAT1-And ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: Individual ACAT uniqueness. J Lipid Res. 2004;45:378-386.
-
(2004)
J Lipid Res.
, vol.45
, pp. 378-386
-
-
Lada, A.T.1
Davis, M.2
Kent, C.3
-
22
-
-
77957771843
-
High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors
-
Sbiera S, Schmull S, Assie G, et al. High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors. J Clin Endocrinol Metab. 2010;95:E161en]E171.
-
(2010)
J Clin Endocrinol Metab.
, vol.95
, pp. E161-E171
-
-
Sbiera, S.1
Schmull, S.2
Assie, G.3
-
23
-
-
84887838747
-
ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway
-
Xue J, Wei J, Dong X, Zhu C, Li Y, Song A, Liu Z. ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway. J Physiol Sci. 2013;63:435-444.
-
(2013)
J Physiol Sci.
, vol.63
, pp. 435-444
-
-
Xue, J.1
Wei, J.2
Dong, X.3
Zhu, C.4
Li, Y.5
Song, A.6
Liu, Z.7
-
24
-
-
84901832063
-
Activation of the endoplas-mic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
-
Hou NS, Gutschmidt A, Choi DY, et al. Activation of the endoplas-mic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proc Natl Acad Sci USA. 2014;111:E2271-E2280.
-
(2014)
Proc Natl Acad Sci USA.
, vol.111
, pp. E2271-E2280
-
-
Hou, N.S.1
Gutschmidt, A.2
Choi, D.Y.3
-
25
-
-
17644420335
-
Mitotane for adrenocortical carcinoma treatment
-
Hahner S, Fassnacht M. Mitotane for adrenocortical carcinoma treatment. Curr Opin Investig Drugs. 2005;6:386-394.
-
(2005)
Curr Opin Investig Drugs.
, vol.6
, pp. 386-394
-
-
Hahner, S.1
Fassnacht, M.2
-
26
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007;8:519-529.
-
(2007)
Nat Rev Mol Cell Biol.
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
27
-
-
84896706762
-
Regulatory crosstalk within the mammalian unfolded protein response
-
Brewer JW. Regulatory crosstalk within the mammalian unfolded protein response. Cell Mol Life Sci. 2014;71:1067-1079.
-
(2014)
Cell Mol Life Sci.
, vol.71
, pp. 1067-1079
-
-
Brewer, J.W.1
-
28
-
-
84874052860
-
HCG-induced endoplasmic retic-ulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis
-
Park SJ, Kim TS, Park CK, et al. hCG-induced endoplasmic retic-ulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. J Mol Endocrinol. 2013;50:151-166.
-
(2013)
J Mol Endocrinol.
, vol.50
, pp. 151-166
-
-
Park, S.J.1
Kim, T.S.2
Park, C.K.3
-
29
-
-
77956176288
-
Sterol metabolism and SREBP activation
-
Sato R. Sterol metabolism and SREBP activation. Arch Biochem Biophys. 2010;501:177-181.
-
(2010)
Arch Biochem Biophys.
, vol.501
, pp. 177-181
-
-
Sato, R.1
-
30
-
-
79957605136
-
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
-
Fu S, Yang L, Li P, et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature. 2011;473:528-531.
-
(2011)
Nature.
, vol.473
, pp. 528-531
-
-
Fu, S.1
Yang, L.2
Li, P.3
-
31
-
-
0042972934
-
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
-
Feng B, Yao PM, Li Y, et al. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol. 2003;5:781-792.
-
(2003)
Nat Cell Biol.
, vol.5
, pp. 781-792
-
-
Feng, B.1
Yao, P.M.2
Li, Y.3
-
32
-
-
77958003056
-
The role of endoplasmic reticulum stress in the progression of atherosclerosis
-
Tabas I. The role of endoplasmic reticulum stress in the progression of atherosclerosis. Circ Res. 2010;107:839-850.
-
(2010)
Circ Res.
, vol.107
, pp. 839-850
-
-
Tabas, I.1
-
33
-
-
84908082447
-
Stress-responsive regulation of mitochondria through the ER unfolded protein response
-
Rainbolt TK, Saunders JM, Wiseman RL. Stress-responsive regulation of mitochondria through the ER unfolded protein response. Trends Endocrinol Metab. 2014;25:528-537.
-
(2014)
Trends Endocrinol Metab.
, vol.25
, pp. 528-537
-
-
Rainbolt, T.K.1
Saunders, J.M.2
Wiseman, R.L.3
-
34
-
-
84871726622
-
Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-Associated membrane (MAM)
-
Raturi A, Simmen T. Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-Associated membrane (MAM). Biochim Biophys Acta. 2013;1833:213-224.
-
(2013)
Biochim Biophys Acta.
, vol.1833
, pp. 213-224
-
-
Raturi, A.1
Simmen, T.2
-
35
-
-
0027973135
-
A unique mitochondria-Associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins
-
Rusiñol AE, Cui Z, Chen MH, Vance JE. A unique mitochondria-Associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J Biol Chem. 1994;269:27494-27502.
-
(1994)
J Biol Chem.
, vol.269
, pp. 27494-27502
-
-
Rusiñol, A.E.1
Cui, Z.2
Chen, M.H.3
Vance, J.E.4
-
36
-
-
0018587012
-
Roleofacylcoenzyme A: Cho-lesterol o-Acyltransferase in cholesterol metabolism
-
Spector AA, Mathur SN, Kaduce TL. Roleofacylcoenzyme A: Cho-lesterol o-Acyltransferase in cholesterol metabolism. Prog Lipid Res. 1979;18:31-53.
-
(1979)
Prog Lipid Res.
, vol.18
, pp. 31-53
-
-
Spector, A.A.1
Mathur, S.N.2
Kaduce, T.L.3
-
38
-
-
80053425950
-
Discovery of a potent and orally available acyl-CoA: Cholesterol acyltransferase inhibitor as an anti-Atherosclerotic agent: (4-phenylcoumarin)acetanilide derivatives
-
Ogino M, Fukui S, Nakada Y, et al. Discovery of a potent and orally available acyl-CoA: Cholesterol acyltransferase inhibitor as an anti-Atherosclerotic agent: (4-phenylcoumarin)acetanilide derivatives. Chem Pharm Bull (Tokyo). 2011;59:1268-1273.
-
(2011)
Chem Pharm Bull (Tokyo).
, vol.59
, pp. 1268-1273
-
-
Ogino, M.1
Fukui, S.2
Nakada, Y.3
-
39
-
-
84880669627
-
ACAT-selective and nonselective DGAT1 inhibition: Adrenocortical effects-A cross-species comparison
-
Floettmann JE, Buckett LK, Turnbull AV, et al. ACAT-selective and nonselective DGAT1 inhibition: Adrenocortical effects-A cross-species comparison. Toxicol Pathol. 2013;41:941-950.
-
(2013)
Toxicol Pathol.
, vol.41
, pp. 941-950
-
-
Floettmann, J.E.1
Buckett, L.K.2
Turnbull, A.V.3
-
40
-
-
0032477856
-
Inhibitors of acyl-CoA:cho-lesterol O-Acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-Activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates
-
Lee HT, Roark WH, Picard JA, et al. Inhibitors of acyl-CoA:cho-lesterol O-Acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-Activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett. 1998;8:289-294.
-
(1998)
Bioorg Med Chem Lett.
, vol.8
, pp. 289-294
-
-
Lee, H.T.1
Roark, W.H.2
Picard, J.A.3
-
41
-
-
79953837350
-
Sterol O-Acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal
-
Ferraz-de-Souza B, Hudson-Davies RE, Lin L, et al. Sterol O-Acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal. J Clin En-docrinol Metab. 2011;96:E663-E668.
-
(2011)
J Clin En-docrinol Metab.
, vol.96
, pp. E663-E668
-
-
Ferraz-De-Souza, B.1
Hudson-Davies, R.E.2
Lin, L.3
-
42
-
-
84877961669
-
Sterol regulatory element binding protein-dependent regulationoflipid synthesis supports cell survival and tumor growth
-
Griffiths B, Lewis CA, Bensaad K, et al. Sterol regulatory element binding protein-dependent regulationoflipid synthesis supports cell survival and tumor growth. Cancer Metab. 2013;1:3.
-
(2013)
Cancer Metab.
, vol.1
, pp. 3
-
-
Griffiths, B.1
Lewis, C.A.2
Bensaad, K.3
-
43
-
-
84895741045
-
Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness
-
Yue S, Li J, Lee SY, et al. Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. Cell Metab. 2014;19:393-406.
-
(2014)
Cell Metab.
, vol.19
, pp. 393-406
-
-
Yue, S.1
Li, J.2
Lee, S.Y.3
-
44
-
-
0021289017
-
The treatment of adrenocortical carcinoma with o, p'-DDD: Prognostic implications of serum level monitoring
-
van Slooten H, Moolenaar AJ, van Seters AP, Smeenk D. The treatment of adrenocortical carcinoma with o, p'-DDD: Prognostic implications of serum level monitoring. Eur J Cancer Clin Oncol. 1984;20:47-53.
-
(1984)
Eur J Cancer Clin Oncol.
, vol.20
, pp. 47-53
-
-
Van Slooten, H.1
Moolenaar, A.J.2
Van Seters, A.P.3
Smeenk, D.4
-
45
-
-
84883393469
-
Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adju-vantly following radical resection
-
Terzolo M, Baudin AE, Ardito A, et al. Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adju-vantly following radical resection. Eur J Endocrinol. 2013;169: 263-270.
-
(2013)
Eur J Endocrinol.
, vol.169
, pp. 263-270
-
-
Terzolo, M.1
Baudin, A.E.2
Ardito, A.3
-
46
-
-
84889768438
-
Comparison of two mito-tane starting dose regimensinpatientswith advanced adrenocortical carcinoma
-
Kerkhofs T, Baudin E, Terzolo M, et al. Comparison of two mito-tane starting dose regimensinpatientswith advanced adrenocortical carcinoma. J Clin Endocrinol Metab. 2013;98:4759-4767.
-
(2013)
J Clin Endocrinol Metab.
, vol.98
, pp. 4759-4767
-
-
Kerkhofs, T.1
Baudin, E.2
Terzolo, M.3
|