Platelets promote allergic asthma through the expression of CD154

Cellular and Molecular Immunology

Volumn 12, Issue 6, 2015, Pages 700-707

  Tian, Jun ^a,b   Zhu, Tianyi ^c   Liu, Juan ^b   Guo, Zhenhong ^b   Cao, Xuetao ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

allergic asthma; CD154; platelet; regulatory T cells; Th2 response

Indexed keywords

CD40 LIGAND; IMMUNOGLOBULIN E; OVALBUMIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FOXP3+ REGULATORY T LYMPHOCYTE; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PNEUMONIA; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TH2 CELL; THROMBOCYTE; THROMBOCYTE ACTIVATION; UPREGULATION; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; PATHOLOGY; SIGNAL TRANSDUCTION; THROMBOCYTE TRANSFUSION;

ANIMALS; ASTHMA; BLOOD PLATELETS; CD40 LIGAND; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN E; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; PLATELET ACTIVATION; PLATELET TRANSFUSION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 84946011045     PISSN: 16727681     EISSN: 20420226     Source Type: Journal    
DOI: 10.1038/cmi.2014.111     Document Type: Article

References (41)

1. Semple JW, Italiano JE Jr, Freedman J. Platelets and the immune continuum. Nat Rev Immunol 2011; 11: 264-274.
2. Yeaman MR. Platelets: at the nexus of antimicrobial defence. Nat Rev Microbiol 2014; 12: 426-437.
3. Morrell CN, Aggrey AA, Chapman LM, Modjeski KL. Emerging roles for platelets as immune and inflammatory cells. Blood 2014; 123: 2759-2767.
4. Mantovani A, Garlanda C. Platelet-macrophage partnership in innate immunity and inflammation. Nat Immunol 2013; 14: 768-770.
5. Grewal IS1, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998; 16: 111-135.
6. Henn V, Slupsky JR, Gräfe M, Anagnostopoulos I, Förster R, Müller-Berghaus G, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591-594.
7. Elzey BD, Grant JF, Sinn HW, Nieswandt B, Waldschmidt TJ, Ratliff TL. Cooperation between platelet-derived CD154 and CD41 T cells for enhanced germinal center formation. J Leukoc Biol 2005; 78: 80-84.
8. Sprague DL, Elzey BD, Crist SA, Waldschmidt TJ, Jensen RJ, Ratliff TL. Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 2008; 111: 5028-5036.
9. Elzey BD, Schmidt NW, Crist SA, Kresowik TP, Harty JT, Nieswandt B, et al. Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood 2008; 111: 3684-3691.
10. Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med 2005; 11: 1167-1169
11. Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, et al. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 2003; 19: 9-19.
12. Gawaz M, Dickfeld T, Bogner C, Fateh-Moghadam S, Neumann FJ. Platelet function in septic multiple organ dysfunction syndrome. Intensive Care Med 1997; 23: 379-385.
13. Dav G Ptrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-2494.
14. Russ M, Seliger B, Hauptmann S, Marty R, Bukur J, Eriksson U, et al. Platelet-depletion ameliorates cardiac function and disease severity in experimental autoimmune myocarditis. Circulation 2008; 118: S516.
15. Duffau P, Seneschal J, Nicco C, Richez C, Lazaro E, Douchet I, et al. Platelet CD154 potentiates interferon-Alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus. Sci Transl Med 2010; 2: 47ra63.
16. Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, WeinblattME, et al. Platelets amplify inflammation in arthritis via collagendependent microparticle production. Science 2010; 327: 580-583.
17. Wang F, Wang NS, Yan CG, Li JH, Tang LQ. The significance of platelet activation in rheumatoid arthritis. Clin Rheumatol 2007; 26: 768-771.
18. Gasparyan AY, Stavropoulos-Kalinoglou A, Mikhailidis DP, Douglas KM, Kitas GD. Platelet function in rheumatoid arthritis: arthritic and cardiovascular implications. Rheumatol Int 2011; 31: 153-164.
19. Pamuk GE, Vural O, Turgut B, Demir M, Pamuk ON, Cakir N. Increased platelet activation markers in rheumatoid arthritis: are they related with subclinical atherosclerosis? Platelets 2008; 19: 146-154.
20. Holgate ST. Innate and adaptive immune responses in asthma. Nat Med 2012; 18: 673-683.
21. Yamamoto H, Nagata M, Tabe K, Kimura I, Kiuchi H, Sakamoto Y, et al. The evidence of platelet activation in bronchial asthma. J Allergy Clin Immunol 1993; 91: 79-87.
22. Pitchford SC, Page CP. Platelet activation in asthma: integral to the inflammatory response. Clin Exp Allergy 2006; 36: 399-401.
23. Benton AS, Kumar N, Lerner J, Wiles AA, Foerster M, Teach SJ, et al. Airway platelet activation is associated with airway eosinophilic inflammation in asthma. J Investig Med 2010; 58: 987-990.
24. Kowal K, Pampuch A, Kowal-Bielecka O, Iacoviello L, Bodzenta-Lukaszyk A. Soluble CD40 ligand in asthma patients during allergen challenge. J Thromb Haemost 2006; 4: 2718-2720.
25. Liu J, Han C, Xie B, Wu Y, Liu S, Chen K, et al. Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. Nat Immunol 2014; 15: 612-622.
26. Chen W, Han C, Xie B, Hu X, Yu Q, Shi L, et al. Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell 2013; 31: 467-478.
27. Li Q, Guo Z, Xu X, Xia S, Cao X. Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur J Immunol 2008; 38: 2751-2761
28. Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity 2009; 31: 425-437.
29. Hansbro PM, Kaiko GE, Foster PS. Cytokine/anti-cytokine therapy-novel treatments for asthma? Br J Pharmacol 2011; 163: 81-95.
30. Propst SM, Denson R, Rothstein E, Estell K, Schwiebert LM. Proinflammatory and Th2-derived cytokines modulate CD40-mediated expression of inflammatory mediators in airway epithelia: implications for the role of epithelial CD40 in airway inflammation. J Immunol 2000; 165: 2214-2221.
31. Suzuki M, Zheng X, Zhang X, Ichim TE, Sun H, Kubo N,et al. Inhibition of allergic responses by CD40 gene silencing. Allergy 2009; 64: 387-397.
32. Hong GU, Park BS, Park JW, Kim SY, Ro JY. IgE production in CD40/CD40L cross-Talk of B and mast cells and mediator release via TGase 2 in mouse allergic asthma. Cell Signal 2013; 25: 1514-1525.
33. Park JH, Chang HS, Park CS, Jang AS, Park BL, Rhim TY, et al. Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. Am J Respir Crit Care Med 2007; 175: 775-782.
34. Takahashi H, Ebihara S, Kanda A, Kamanaka M, Sato T, Habu S, et al. Increased susceptibility to airway responses in CD40-deficient mice. Clin Exp Immunol 2003; 133: 22-29.
35. Palomares O, Yaman G, Azkur AK, Akkoc T, Akdis M, Akdis CA. Role of Treg in immune regulation of allergic diseases. Eur J Immunol 2010; 40: 1232-1240.
36. Jenabian MA, Patel M, Kema I, Vyboh K, Kanagaratham C, Radzioch D, et al. Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T-cell expansion in HIV infection. Clin Exp Immunol 2014; doi: 10.1111/cei.12396.
37. Huang J, Jochems C, Talaie T, Anderson A, Jales A, Tsang KY, et al. Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role. Blood 2012; 120: 3030-3038.
38. Zheng J, Liu Y, Lau YL, Tu W. CD40-Activated B cells are more potent than immature dendritic cells to induce and expand CD41 regulatory T cells. Cell Mol Immunol 2010; 7: 44-50.
39. Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix IC, et al. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 2010; 116: 4317-4327.
40. Gerdes N, Zhu L, Ersoy M, Hermansson A, Hjemdahl P, Hu H, et al. Platelets regulate CD41 T-cell differentiation via multiple chemokines in humans. Thromb Haemost 2011; 106: 353-362.
41. Vaitaitis GM, Wagner DH Jr. CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression. Cell Mol Immunol 2013; 10: 483-489.