X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 22, 2015, Pages 5072-5077

  St John, Sarah E ^a   Therkelsen, Matthew D ^a   Nyalapatla, Prasanth R ^a   Osswald, Heather L ^a   Ghosh, Arun K ^a   Mesecar, Andrew D ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

3CLpro; Coronavirus; Feline infectious peritonitis; Peptidomimetics; Structure based drug design

Indexed keywords

ENZYME INHIBITOR; PEPTIDOMIMETIC AGENT; PROTEINASE; PROTEINASE 3CLPRO; UNCLASSIFIED DRUG; VIRUS ENZYME; 3C-LIKE PROTEINASE, CORONAVIRUS; ANTIVIRUS AGENT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; OLIGOPEPTIDE;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME STRUCTURE; FELINE INFECTIOUS PERITONITIS VIRUS; HYDROGEN BOND; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; NONHUMAN; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; ESCHERICHIA COLI; FELINE CORONAVIRUS; KINETICS; MOLECULAR MODEL; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTIVIRAL AGENTS; CATALYTIC DOMAIN; CORONAVIRUS, FELINE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; ESCHERICHIA COLI; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDOMIMETICS;

EID: 84945962524     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.10.023     Document Type: Article

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