Transforming growth factor β1-mediated anti-inflammation slows progression of midbrain dopaminergic neurodegeneration in parkinson’s disease?

Neural Regeneration Research

Volumn 10, Issue 10, 2015, Pages 1578-1580

  Spittau, Björn ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GAMMA INTERFERON; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; LEUCINE RICH REPEAT KINASE 2; MESSENGER RNA; NITRIC OXIDE; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA;

CELL ACTIVATION; DISEASE COURSE; DOPAMINERGIC NERVE CELL; HUMAN; INTRACELLULAR SIGNALING; MESENCEPHALON; MICROGLIA; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NOTE; PARKINSON DISEASE; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY MECHANISM;

EID: 84945560217     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.165228     Document Type: Note

References (15)

1. Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69
2. Bortolanza M, Cavalcanti-Kiwiatkoski R, Padovan-Neto FE, da-Silvi CA, Mitkovski M, Raisman-Vozari R, Del-Bel E (2014) Glial activation is associated with L-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinsons’s disease. Neurobiol Dis 73C:377-387
3. Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL (2014) Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci 17:131-143
4. Cebrian C, Loike JD, Sulzer D (2015) Neuroinflammation in Parkinson’s disease animal models: a cell stress response or a step in neurodegeneration? Curr Top Behav Neurosci 22:237-270
5. Hirsch EC, Hunot S (2009) Neuroinflammation in Parkinson’s disease: a target for neuroprotection? Lancet Neurol 8:382-397
6. Kiefer R, Streit WJ, Toyka KV, Kreutzberg GW, Hartung HP (1995) Transforming growth factor-beta 1: a lesion-associated cytokine of the nervous system. Int J Dev Neurosci 13:331-339
7. Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, Anisman H, Hayley S, Park DS (2007) Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J Neurosci 27:3328-3337
8. Pal G, Lovas G, Dobolyi A (2014) Induction of transforming growth factor beta receptors following focal ischemia in the rat brain. PLoS One 9:e106544
9. Roussa E, von Bohlen und Halbach O, Krieglstein K (2009) TGF-beta in dopamine neuron development, maintenance and neuroprotection. Adv Exp Med Biol 651:81-90
10. Schober A, Peterziel H, von Bartheld CS, Simon H, Krieglstein K, Unsicker K (2007) GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action. Neurobiol Dis 25:378-391
11. Spittau B, Wullkopf L, Zhou X, Rilka J, Pfeifer D, Krieglstein K (2013) Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro. Glia 61:287-300
12. Vincze C, Pal G, Wappler EA, Szabo ER, Nagy ZG, Lovas G, Dobolyi A (2010) Distribution of mRNAs encoding transforming growth factors-beta1, -2, and -3 in the intact rat brain and after experimentally induced focal ischemia. J Comp Neurol 518:3752-3770
13. Zhou X, Spittau B, Krieglstein K (2012) TGFβ signalling plays an important role in IL4-induced alternative activation of microglia. J Neuroinflammation 9:210
14. Zhou X, Zoller T, Krieglstein K, Spittau B (2015) TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity. J Neurochem 134:125-134
15. Zlotnik A, Spittau B (2014) GDNF fails to inhibit LPS-mediated activation of mouse microglia. J Neuroimmunol 270:22-28.