Macrophages Are Involved in Gut Bacterial Translocation and Reversed by Lactobacillus in Experimental Uremia

Digestive Diseases and Sciences

Volumn 61, Issue 6, 2016, Pages 1534-1544

  Sun, Lingshuang ^a   Liu, Hua ^a   Jiang, Hongli ^a   Wei, Meng ^a   Liang, Shanshan ^a   Wang, Meng ^a   Shi, Kehui ^a   He, Quan ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Bacterial translocation; Macrophages; Microinflammation; Probiotics; Uremia

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CD68 ANTIGEN; CREATININE; EARLY GROWTH RESPONSE FACTOR 1; GREEN FLUORESCENT PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MESSENGER RNA; PROBIOTIC AGENT; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; EGR1 PROTEIN, RAT; ENDOTOXIN; TLR4 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; CELL ULTRASTRUCTURE; COLON; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENTERITIS; FLUORESCENCE MICROSCOPY; ILEUM; IMMUNOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE FLORA; JEJUNUM; LACTOBACILLUS; LAMINA PROPRIA; MACROPHAGE FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBMUCOSA; TRANSMISSION ELECTRON MICROSCOPY; UREA NITROGEN BLOOD LEVEL; UREMIA; WESTERN BLOTTING; ANIMAL; BLOOD; CYTOLOGY; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; INTESTINE MUCOSA; MACROPHAGE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIGENS, CD11A; BACTERIAL TRANSLOCATION; BIOMARKERS; EARLY GROWTH RESPONSE PROTEIN 1; ENDOTOXINS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTESTINAL MUCOSA; LACTOBACILLUS; MACROPHAGES; MALE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; UREMIA;

EID: 84945557937     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-015-3950-z     Document Type: Article

References (30)

1. Schindler R. Causes and therapy of microinflammation in renal failure. Nephrol Dial Transplant. 2004;19:v34–v40.
2. Vaziri ND, Zhao Y-Y, Pahl MV. Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment. Nephrol Dial Transplant. 2015. doi:10.1093/ndt/gfv095.
3. Wei M, Wang Z, Liu H, et al. Probiotic Bifidobacterium animalis subsp. lactis Bi-07 alleviates bacterial translocation and ameliorates microinflammation in experimental uraemia. Nephrology (Carlton). 2014;19:500–506.
4. Wang F, Zhang P, Jiang H, Cheng S. Gut bacterial translocation contributes to microinflammation in experimental uremia. Dig Dis Sci. 2012;57:2856–2862.
5. Zhou D, Huang C, Lin Z, et al. Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal. 2014;26:192–197.
6. Chawla A, Nguyen KD, Goh YS. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol. 2011;11:738–749.
7. Chakravortty D, Etienne-Mesmin L, Chassaing B, et al. Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorragic Escherichia coli infections. PLoS ONE. 2011;6:e23594.
8. Kiechl S, Lorenz E, Reindl M, et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med. 2002;347:185–192.
9. Xu Z, Dziarski R, Wang Q, Swartz K, Sakamoto KM, Gupta D. Bacterial peptidoglycan-induced TNF-α transcription is mediated through the transcription factors Egr-1, Elk-1, and NF-κB. J Immunol. 2001;167:6975–6982.
10. Anders HJ, Andersen K, Stecher B. The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. Kidney Int. 2013;83:1010–1016.
11. Wang F, Jiang H, Shi K, Ren Y, Zhang P, Cheng S. Gut bacterial translocation is associated with microinflammation in end-stage renal disease patients. Nephrology (Carlton). 2012;17:733–738.
12. Servin AL. Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiol Rev. 2004;28:405–440.
13. Delcenserie V, Martel D, Lamoureux M, Amiot J, Boutin Y, Roy D. Immunomodulatory effects of probiotics in the intestinal tract. Curr Issues Mol Biol. 2008;10:37.
14. Bujalance C, Jiménez-Valera M, Moreno E, Ruiz-López M-D, Lasserrot A, Ruiz-Bravo A. Lack of correlation between in vitro antibiosis and in vivo protection against enteropathogenic bacteria by probiotic lactobacilli. Res Microbiol. 2014;165:14–20.
15. Mafra D, Fouque D. Gut microbiota and inflammation in chronic kidney disease patients. Clin Kidney J. 2015;8:332–334.
16. Vaziri ND, Goshtasbi N, Yuan J, et al. Uremic plasma impairs barrier function and depletes the tight junction protein constituents of intestinal epithelium. Am J Nephrol. 2012;36:438.
17. Benoit M, Desnues B, Mege J-L. Macrophage polarization in bacterial infections. J Immunol. 2008;181:3733–3739.
18. Raabe T, Bukrinsky M, Currie RA. Relative contribution of transcription and translation to the induction of tumor necrosis factor-α by lipopolysaccharide. J Biol Chem. 1998;273:974–980.
19. Coleman D, Bartiss A, Sukhatme V, Liu J, Rupprecht H. Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages. J Immunol. 1992;149:3045–3051.
20. Kawasaki K, Yaoita E, Yamamoto T, Tamatani T, Miyasaka M, Kihara I. Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in rat experimental crescentic glomerulonephritis. J Immunol. 1993;150:1074–1083.
21. Marlin SD, Springer TA. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell. 1987;51:813–819.
22. Bossola M, Sanguinetti M, Scribano D, et al. Circulating bacterial-derived DNA fragments and markers of inflammation in chronic hemodialysis patients. Clin J Am Soc Nephrol. 2009;4:379–385.
23. Shi K, Wang F, Jiang H, et al. Gut bacterial translocation may aggravate microinflammation in hemodialysis patients. Dig Dis Sci. 2014;59:2109–2117.
24. ®. Microorganisms. 2014;2:92–110.
25. Agostini S, Goubern M, Tondereau V, et al. A marketed fermented dairy product containing Bifidobacterium lactis CNCM I-2494 suppresses gut hypersensitivity and colonic barrier disruption induced by acute stress in rats. Neurogastroenterol Motil. 2012;24:376-e172.
26. Klein A, Friedrich U, Vogelsang H, Jahreis G. Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr. 2008;62:584–593.
27. Liévin-Le Moal V, Servin AL. Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clin Microbiol Rev. 2014;27:167–199.
28. Akoglu B, Loytved A, Nuiding H, Zeuzem S, Faust D. Probiotic Lactobacillus casei Shirota improves kidney function, inflammation and bowel movements in hospitalized patients with acute gastroenteritis—a prospective study. J Funct Foods. 2015;17:305–313.
29. Alatriste PVM, Arronte RU, Espinosa COG, Cuevas MDLÁE. Effect of probiotics on human blood urea levels in patients with chronic renal failure. Nutr Hosp. 2014;29:582–590.
30. Bai YH, Jiang YF, Jiang YS. Lactobacillus bulgaricus mutants decompose uremic toxins. Ren Fail. 2014;36:790–794.