Human α7 integrin gene (ITGA7) delivered by adeno-associated virus extends survival of severely affected dystrophin/utrophin-deficient mice

Human Gene Therapy

Volumn 26, Issue 10, 2015, Pages 647-656

  Heller, Kristin N ^a,b   Montgomery, Chrystal L ^a,b   Shontz, Kimberly M ^a,b   Clark, K Reed ^a,b   Mendell, Jerry R ^a,b   Rodino Klapac, Louise R ^a,b  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA7 INTEGRIN; GENE THERAPY AGENT; ALPHA INTEGRIN; DYSTROPHIN; LEUKOCYTE ANTIGEN;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL COUNT; CLINICAL FEATURE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; DISEASE SEVERITY; DOWN REGULATION; DUCHENNE MUSCULAR DYSTROPHY; ECCENTRIC MUSCLE CONTRACTION; EXTENSOR DIGITORUM LONGUS MUSCLE; GASTROCNEMIUS MUSCLE; GENE OVEREXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; KYPHOSIS; MOUSE; MUSCLE CELL; MUSCLE NECROSIS; MUSCLE WEAKNESS; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; QUADRICEPS FEMORIS MUSCLE; RESPIRATORY TRACT DISEASE; SARCOLEMMA; SURVIVAL RATE; UPREGULATION; UTROPHIN DEFICIENCY; ANIMAL; BIOSYNTHESIS; DEFICIENCY; DEPENDOPARVOVIRUS; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; MUSCULAR DYSTROPHY, ANIMAL; MUSCULAR DYSTROPHY, DUCHENNE; PATHOLOGY; PROCEDURES;

ANIMALS; ANTIGENS, CD; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DYSTROPHIN; GENE EXPRESSION REGULATION; GENETIC THERAPY; HUMANS; INTEGRIN ALPHA CHAINS; MICE; MUSCULAR DYSTROPHY, ANIMAL; MUSCULAR DYSTROPHY, DUCHENNE;

EID: 84945549011     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2015.062     Document Type: Article

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