Spotlight on inflammation in pulmonary hypertension

American Journal of Respiratory and Critical Care Medicine

Volumn 192, Issue 8, 2015, Pages 913-915

  Grunig, Gabriele ^a,b   Durmus, Nedim ^a,b  

^a Department of Environmental Medicine ^*  (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHELMINTIC AGENT; CD74 ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 4; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCROTALINE; PADGEM PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE 1; B LYMPHOCYTE ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HLA ANTIGEN CLASS 2; INTERCELLULAR ADHESION MOLECULE 1;

BONE MARROW CELL; CELL COUNT; CELL FUNCTION; CELL MIGRATION; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EDITORIAL; ENDOTHELIUM CELL; ENZYME ACTIVATION; FIBROSIS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PULMONARY HYPERTENSION; SCHISTOSOMA; SCHISTOSOMIASIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; T LYMPHOCYTE; TH2 CELL; UPREGULATION; VASCULAR REMODELING; ANIMAL; FEMALE; IMMUNOLOGY; MACROPHAGE; MALE; SCHISTOSOMIASIS MANSONI; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; E-SELECTIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FAMILIAL PRIMARY PULMONARY HYPERTENSION; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; HYPERTENSION, PULMONARY; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-13; INTERLEUKIN-4; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MACROPHAGES; MALE; SCHISTOSOMIASIS MANSONI; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84945539662     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201507-1426ED     Document Type: Editorial

References (15)

1. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Rodriguez Garcia A, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, et al. The causal role of IL-4 and IL-13 in Schistosoma mansoni pulmonary hypertension. Am J Respir Crit Care Med 2015;192: 998-1008.
2. Le Hiress M, Tu L, Ricard N, Phan C, Thuillet R, Fadel E, Dorfmuller P, Montani D, de Man F, Humbert M, et al. Proinflammatory signature of the dysfunctional endothelium in pulmonary hypertension: role of the macrophage migration inhibitory factor/CD74 complex. Am J Respir Crit Care Med 2015;192:983-997.
3. Becker H, Willeke P, Schotte H, Domschke W, Gaubitz M. Macrophage migration inhibitory factor may contribute to vasculopathy in systemic sclerosis. Clin Rheumatol 2008;27:1307-1311.
4. Zhang B, Luo Y, Liu ML, Wang J, Xu DQ, Dong MQ, Liu Y, Xu M, Dong HY, Zhao PT, et al. Macrophage migration inhibitory factor contributes to hypoxic pulmonary vasoconstriction in rats. Microvasc Res 2012;83:205-212.
5. Zhang Y, Talwar A, Tsang D, Bruchfeld A, Sadoughi A, Hu M, Omonuwa K, Cheng KF, Al-Abed Y, Miller EJ. Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension. Mol Med 2012;18:215-223.
6. Wilson MS, Mentink-Kane MM, Pesce JT, Ramalingam TR, Thompson R, Wynn TA. Immunopathology of schistosomiasis. Immunol Cell Biol 2007;85:148-154.
7. Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, et al. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol 2010;177:1549-1561.
8. Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, et al. Transforming growth factor-b signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation 2013;128: 1354-1364.
9. Graham BB, Chabon J, Bandeira A, Espinheira L, Butrous G, Tuder RM. Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension. Pulm Circ 2011;1:456-461.
10. Das R, Moss JE, Robinson E, Roberts S, Levy R, Mizue Y, Leng L, McDonald C, Tigelaar RE, Herrick CA, et al. Role of macrophage migration inhibitory factor in the Th2 immune response to epicutaneous sensitization. J Clin Immunol 2011;31:666-680.
11. Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, et al. Cutting edge: deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol 2006;177:5779-5784.
12. Sironi M, Sciacca FL, Matteucci C, Conni M, Vecchi A, Bernasconi S, Minty A, Caput D, Ferrara P, Colotta F, et al. Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production. Blood 1994;84: 1913-1921.
13. Woltmann G, McNulty CA, Dewson G, Symon FA, Wardlaw AJ. Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow. Blood 2000;95:3146-3152.
14. Park SH, Chen WC, Esmaeil N, Lucas BEG, Marsh LM, Reibman J, Grunig G. Interleukin 13-and interleukin 17A-induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution. Pulm Circ 2014;4:654-668.
15. Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, Taraseviciene-Stewart L, Voelkel NF, Rabinovitch M, et al. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med 2008;205:361-372.