Long non-coding RNA-LET is a positive prognostic factor and exhibits tumor-suppressive activity in gallbladder cancer

Molecular Carcinogenesis

Volumn 54, Issue 11, 2015, Pages 1397-1406

  Ma, Ming Zhe ^a,b   Kong, Xiang ^a,c   Weng, Ming Zhe ^a   Zhang, Ming Di ^a   Qin, Yi Yu ^a   Gong, Wei ^a   Zhang, Wen Jie ^a   Quan, Zhi Wei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b YANGZHOU UNIVERSITY   (China)

^c WANNAN MEDICAL COLLEGE   (China)

Author keywords

Gallbladder cancer; Hypoxia; LncRNA LET; Long non coding RNA; Prognosis

Indexed keywords

LONG UNTRANSLATED RNA; LONG UNTRANSLATED RNA LET; UNCLASSIFIED DRUG; TUMOR MARKER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL FUNCTIONS; CANCER CELL; CANCER INHIBITION; CANCER PROGNOSIS; CANCER RISK; CANCER STAGING; CELL INVASION ASSAY; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GALLBLADDER CANCER; GALLBLADDER TUMOR; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR BIOLOGY; MOUSE; MTT ASSAY; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; APOPTOSIS; CELL CYCLE G0 PHASE; GENE EXPRESSION REGULATION; GENETICS; NUDE MOUSE; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BIOMARKERS, TUMOR; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; G0 PHASE; G1 PHASE CELL CYCLE CHECKPOINTS; GALLBLADDER NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, NUDE; MIDDLE AGED; PROGNOSIS; RNA, LONG NONCODING;

EID: 84945489437     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22215     Document Type: Article

References (20)

1. Zhu AX, Hong TS, Hezel AF, Kooby DA. Current management of gallbladder carcinoma. Oncologist 2010; 15:168-181.
2. Gold DG, Miller RC, Haddock MG, et al. Adjuvant therapy for gallbladder carcinoma: the Mayo Clinic Experience. Int J Radiat Oncol Biol Phys 2009; 75:150-155.
3. Caldow Pilgrim CH, Groeschl RT, Quebbeman EJ, Gamblin TC. Recent advances in systemic therapies and radiotherapy for gallbladder cancer. Surg Oncol 2013; 22:61-67.
4. Fachel AA, Tahira AC, Vilella-Arias SA, et al. Expression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: emerging functional associations. Mol Cancer 2013; 12:140.
5. Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet 2009; 10:155-159.
6. Ge XS, Ma HJ, Zheng XH, et al. HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci 2013; 104:1675-1682.
7. Huang JF, Guo YJ, Zhao CX, et al. Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Hepatology 2013; 57:1882-1892.
8. Yang F, Zhang L, Huo XS, et al. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology 2011; 54:1679-1689.
9. Yang F, Huo XS, Yuan SX, et al. Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell 2013; 49:1083-1096.
10. Wang JH, Li LF, Yu Y, et al. Establishment and characterization of a cell line, EH-GB2, derived from hepatic metastasis of gallbladder cancer. Oncol Rep 2012; 27:775-782.
11. Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nature Rev Cancer 2011; 11:393-410.
12. Natsuizaka M, Kinugasa H, Kagawa S, et al. IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment. Am J Cancer Res 2014; 4:39-41.
13. Xi Y, Wei Y, Sennino B, et al. Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia. Oncogene 2013; 32:5048-5057.
14. Lock FE, McDonald PC, Lou Y, et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene 2013; 32:5210-5219.
15. Noman MZ, Buart S, Romero P, et al. Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells. Cancer Res 2012; 72:4629-4641.
16. Chang Y, Yan W, He X, et al. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology 2012; 143:177-187.
17. Ying Q, Liang L, Guo W, et al. Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology 2011; 54:2064-2075.
18. Ferdin J, Nishida N, Wu X, et al. HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts. Cell Death Differ 2013; 20:1675-1687.
19. Matouk IJ, Mezan S, Mizrahi A, et al. The oncofetal H19 RNA connection: hypoxia, p53 and cancer. Biochim Biophys Acta 2010; 1803:443-451.
20. Matouk IJ, DeGroot N, Mezan S, et al. The H19 non-coding RNA is essential for human tumor growth. PLoS One 2007; 2:e845.