Association of race with mortality and cardiovascular events in a large cohort of US veterans

Circulation

Volumn 132, Issue 16, 2015, Pages 1538-1548

  Kovesdy, Csaba P ^a,b   Norris, Keith C ^c   Boulware, L Ebony ^d   Lu, Jun L ^b   Ma, Jennie Z ^e   Streja, Elani ^f   Molnar, Miklos Z ^b   Kalantar Zadeh, Kamyar ^f  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cohort studies; continental population groups; coronary disease; mortality; stroke

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ACUTE HEART INFARCTION; ADULT; ARTICLE; BLACK PERSON; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUCASIAN; CEREBROVASCULAR ACCIDENT; CHOLESTEROL BLOOD LEVEL; CHRONIC LUNG DISEASE; COHORT ANALYSIS; CORONARY ARTERY BYPASS GRAFT; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DRUG USE; EDUCATIONAL STATUS; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTENSION; INFLUENZA VACCINATION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MARRIAGE; MORTALITY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PERCUTANEOUS CORONARY INTERVENTION; POVERTY; PRIORITY JOURNAL; RACE DIFFERENCE; SENSITIVITY ANALYSIS; SOCIAL STATUS; SYSTOLIC BLOOD PRESSURE; VETERAN; AGED; CORONARY ARTERY DISEASE; ETHNOLOGY; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; BRAIN ISCHEMIA; COHORT STUDIES; CORONARY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; STROKE; VETERANS;

EID: 84945486804     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.015124     Document Type: Article

References (52)

1. US Census Bureau. State and County QuickFacts. http://quickfacts.census.gov/qfd/states/00000.html. Accessed December 15, 2014
2. Infant mortality and low birth weight among black and white infants-United States, 1980-2000. MMWR Morb Mortal Wkly Rep 2002 51 589 592
3. Tucker MJ, Berg CJ, Callaghan WM, Hsia J, The black-white disparity in pregnancy-related mortality from 5 conditions: differences in prevalence and case-fatality rates. Am J Public Health 2007 97 247 251. doi: 10.2105/AJPH.2005.072975.
4. Gold DR, Wright R, Population disparities in asthma. Annu Rev Public Health 2005 26 89 113. doi: 10.1146/annurev.publhealth.26.021304.144528.
5. Hyman DJ, Pavlik VN, Characteristics of patients with uncontrolled hypertension in the United States. N Engl J Med 2001 345 479 486. doi: 10.1056/NEJMoa010273.
6. Clark LT, Ferdinand KC, Flack JM, Gavin JR 3rd, Hall WD, Kumanyika SK, Reed JW, Saunders E, Valantine HA, Watson K, Wenger NK, Wright JT, Coronary heart disease in African Americans. Heart Dis 2001 3 97 108
7. Mays VM, Cochran SD, Barnes NW, Race, race-based discrimination, and health outcomes among African Americans. Annu Rev Psychol 2007 58 201 225. doi: 10.1146/annurev.psych.57.102904.190212.
8. Freedman BI, Register TC, Effect of race and genetics on vitamin D metabolism, bone and vascular health. Nat Rev Nephrol 2012 8 459 466. doi: 10.1038/nrneph.2012.112.
9. Foster MC, Coresh J, Fornage M, Astor BC, Grams M, Franceschini N, Boerwinkle E, Parekh RS, Kao WH, APOL1 variants associate with increased risk of CKD among African Americans. J Am Soc Nephrol 2013 24 1484 1491. doi: 10.1681/ASN.2013010113.
10. Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR, The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol 2010 21 1422 1426. doi: 10.1681/ASN.2010070730.
11. Friedman DJ, Kozlitina J, Genovese G, Jog P, Pollak MR, Population-based risk assessment of APOL1 on renal disease. J Am Soc Nephrol 2011 22 2098 2105. doi: 10.1681/ASN.2011050519.
12. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR, Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 2010 329 841 845. doi: 10.1126/science.1193032.
13. Tzur S, Rosset S, Shemer R, Yudkovsky G, Selig S, Tarekegn A, Bekele E, Bradman N, Wasser WG, Behar DM, Skorecki K, Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Hum Genet 2010 128 345 350. doi: 10.1007/s00439-010-0861-0.
14. Kalantar-Zadeh K, Kovesdy CP, Derose SF, Horwich TB, Fonarow GC, Racial and survival paradoxes in chronic kidney disease. Nat Clin Pract Nephrol 2007 3 493 506. doi: 10.1038/ncpneph0570.
15. Kovesdy CP, Quarles LD, Lott EH, Lu JL, Ma JZ, Molnar MZ, Kalantar-Zadeh K, Survival advantage in black versus white men with CKD: effect of estimated GFR and case mix. Am J Kidney Dis 2013 62 228 235. doi: 10.1053/j.ajkd.2012.12.012.
16. Bild DE, Detrano R, Peterson D, Guerci A, Liu K, Shahar E, Ouyang P, Jackson S, Saad MF, Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2005 111 1313 1320. doi: 10.1161/01.CIR.0000157730.94423.4B.
17. Lee TC, O'Malley PG, Feuerstein I, Taylor AJ, The prevalence and severity of coronary artery calcification on coronary artery computed tomography in black and white subjects. J Am Coll Cardiol 2003 41 39 44
18. Tang W, Arnett DK, Province MA, Lewis CE, North K, Carr JJ, Pankow JS, Hopkins PN, Devereux RB, Wilk JB, Wagenknecht L, Investigators of the FHS and HyperGEN Racial differences in the association of coronary calcified plaque with left ventricular hypertrophy: the National Heart, Lung, and Blood Institute Family Heart Study and Hypertension Genetic Epidemiology Network. Am J Cardiol 2006 97 1441 1448. doi: 10.1016/j.amjcard.2005.11.076.
19. Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie SS, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey CJ, Bowden DW, Divers J, APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Kidney Int 2015 87 176 181. doi: 10.1038/ki.2014.255.
20. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, Powe NR, Thadhani R, Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med 2013 369 1991 2000. doi: 10.1056/NEJMoa1306357.
21. Ferdinand KC, Townsend RR, Hypertension in the US black population: risk factors, complications, and potential impact of central aortic pressure on effective treatment. Cardiovasc Drugs Ther 2012 26 157 165. doi: 10.1007/s10557-011-6367-8.
22. Gosmanova EO, Lu JL, Streja E, Cushman WC, Kalantar-Zadeh K, Kovesdy CP, Association of medical treatment nonadherence with all-cause mortality in newly treated hypertensive US veterans. Hypertension 2014 64 951 957. doi: 10.1161/HYPERTENSIONAHA.114.03805.
23. VA Information Resource Center VIReC Resource Guide: VA Corporate Data Warehouse 2012 Hines, IL US Department of Veterans Affairs, Health Services Research and Development Service, VA Information Resource Center
24. US Department of Veterans Affairs. Veteran population. http://www.va.gov/vetdata/Veteran-Population.asp. Accessed December 15, 2014.
25. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) A new equation to estimate glomerular filtration rate. Ann Intern Med 2009 150 604 612
26. Stroupe KT, Tarlov E, Zhang Q, Haywood T, Owens A, Hynes DM, Use of Medicare and DOD data for improving VA race data quality. J Rehabil Res Dev 2010 47 781 796
27. Sohn MW, Zhang H, Arnold N, Stroupe K, Taylor BC, Wilt TJ, Hynes DM, Transition to the new race/ethnicity data collection standards in the Department of Veterans Affairs. Popul Health Metr 2006 4 7. doi: 10.1186/1478-7954-4-7.
28. Kovesdy CP, Bleyer AJ, Molnar MZ, Ma JZ, Sim JJ, Cushman WC, Quarles LD, Kalantar-Zadeh K, Blood pressure and mortality in U.S. veterans with chronic kidney disease: a cohort study. Ann Intern Med 2013 159 233 242. doi: 10.7326/0003-4819-159-4-201308200-00004.
29. Kovesdy CP, Lu JL, Molnar MZ, Ma JZ, Canada RB, Streja E, Kalantar-Zadeh K, Bleyer AJ, Observational modeling of strict vs conventional blood pressure control in patients with chronic kidney disease. JAMA Intern Med 2014 174 1442 1449. doi: 10.1001/jamainternmed.2014.3279.
30. US Department of Veterans Affairs. VA Information Resource Center. http://www.virec.research.va.gov/Resources/Info-About-VA-Data.asp. Accessed December 15, 2014.
31. VIReC Research User Guide; VHA Medical SAS Inpatient Datasets FY2006 Hines, IL US Department of Veterans Affairs, VA Information Resource Center; September 2007.
32. VIReC Research User Guide; VHA Medical SAS Outpatient Datasets FY2006 Hines, IL US Department of Veterans Affairs, VA Information Resource Center; September 2007.
33. Sohn MW, Arnold N, Maynard C, Hynes DM, Accuracy and Completeness of Mortality Data in the Department of Veterans Affairs. Popul Health Metr 2006 4 2
34. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013 3 1 150
35. Fine JP, Gray RJ, A proportional hazards model for the subdistribution of competing risk. J Am Stat Assoc 1999 94 496 509
36. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics Committee and Stroke Statistics Subcommittee Executive summary: heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation 2014 129 399 410. doi: 10.1161/01.cir.0000442015.53336.12.
37. Geronimus AT, Bound J, Waidmann TA, Hillemeier MM, Burns PB, Excess mortality among blacks and whites in the United States. N Engl J Med 1996 335 1552 1558. doi: 10.1056/NEJM199611213352102.
38. Karter AJ, Ferrara A, Liu JY, Moffet HH, Ackerson LM, Selby JV, Ethnic disparities in diabetic complications in an insured population. JAMA 2002 287 2519 2527
39. Gao SW, Oliver DK, Das N, Hurst FP, Lentine KL, Agodoa LY, Sawyers ES, Abbott KC, Assessment of racial disparities in chronic kidney disease stage 3 and 4 care in the department of defense health system. Clin J Am Soc Nephrol 2008 3 442 449. doi: 10.2215/CJN.03940907.
40. Jha AK, Shlipak MG, Hosmer W, Frances CD, Browner WS, Racial differences in mortality among men hospitalized in the Veterans Affairs health care system. JAMA 2001 285 297 303
41. Deswal A, Petersen NJ, Souchek J, Ashton CM, Wray NP, Impact of race on health care utilization and outcomes in veterans with congestive heart failure. J Am Coll Cardiol 2004 43 778 784. doi: 10.1016/j.jacc.2003.10.033.
42. Bennett CL, Horner RD, Weinstein RA, Dickinson GM, DeHovitz JA, Cohn SE, Kessler HA, Jacobson J, Goetz MB, Simberkoff M, Racial differences in care among hospitalized patients with Pneumocystis carinii pneumonia in Chicago, New York, Los Angeles, Miami, and Raleigh-Durham. Arch Intern Med 1995 155 1586 1592
43. Akerley WL 3rd, Moritz TE, Ryan LS, Henderson WG, Zacharski LR, Racial comparison of outcomes of male Department of Veterans Affairs patients with lung and colon cancer. Arch Intern Med 1993 153 1681 1688
44. Dominitz JA, Samsa GP, Landsman P, Provenzale D, Race, treatment, and survival among colorectal carcinoma patients in an equal-Access medical system. Cancer 1998 82 2312 2320
45. Washington DL, Harada ND, Villa VM, Damron-Rodriguez J, Dhanani S, Shon H, Makinodan T, Racial variations in Department of Veterans Affairs ambulatory care use and unmet health care needs. Mil Med 2002 167 235 241
46. Davis TM, Ethnic diversity in type 2 diabetes. Diabet Med 2008 25 suppl 2 52 56. doi: 10.1111/j.1464-5491.2008.02499.x.
47. Davis TM, Coleman RL, Holman RR, UKPDS Group Ethnicity and long-Term vascular outcomes in type 2 diabetes: a prospective observational study (UKPDS 83). Diabet Med 2014 31 200 207. doi: 10.1111/dme.12353.
48. Chinevere TD, Murray CK, Grant E Jr, Johnson GA, Duelm F, Hospenthal DR, Prevalence of glucose-6-phosphate dehydrogenase deficiency in U.S. Army personnel. Mil Med 2006 171 905 907
49. Hecker PA, Leopold JA, Gupte SA, Recchia FA, Stanley WC, Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease. Am J Physiol Heart Circ Physiol 2013 304 H491 H500. doi: 10.1152/ajpheart.00721.2012.
50. Mozos I, Mechanisms linking red blood cell disorders and cardiovascular diseases. Biomed Res Int 2015 2015 682054. doi: 10.1155/2015/682054.
51. Gillum RF, Mussolino ME, Madans JH, Coronary heart disease incidence and survival in African-American women and men: the NHANES I Epidemiologic Follow-up Study. Ann Intern Med 1997 127 111 118
52. Howard VJ, Kleindorfer DO, Judd SE, McClure LA, Safford MM, Rhodes JD, Cushman M, Moy CS, Soliman EZ, Kissela BM, Howard G, Disparities in stroke incidence contributing to disparities in stroke mortality. Ann Neurol 2011 69 619 627. doi: 10.1002/ana.22385.