Oxidative stress and antioxidant levels in patients with anorexia nervosa: A systematic review and exploratory meta-analysis

International Journal of Eating Disorders

Volumn 48, Issue 7, 2015, Pages 826-841

  Solmi, Marco ^a   Veronese, Nicola ^a   Manzato, Enzo ^a   Sergi, Giuseppe ^a   Favaro, Angela ^a   Santonastaso, Paolo ^a   Correll, Christoph U ^b,c,d,e  

^a UNIVERSITY OF PADOVA   (Italy)

^b ZUCKER HILLSIDE HOSPITAL   (United States)

^c DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

anorexia nervosa; antioxidant; healthy controls; oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; APOLIPOPROTEIN B; ASCORBIC ACID; CATALASE; CYSTEINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; NITRATE; NITRIC OXIDE; NITRITE; RETINOL; SELENIUM; SERUM ALBUMIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ZINC; BIOLOGICAL MARKER;

AGE; ANOREXIA NERVOSA; BODY MASS; CANADA; EUROPE; HUMAN; JAPAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; BLOOD; CROSS-SECTIONAL STUDY; FEMALE; META ANALYSIS; METABOLISM; NORMAL HUMAN; YOUNG ADULT;

ANOREXIA NERVOSA; ANTIOXIDANTS; BIOMARKERS; CROSS-SECTIONAL STUDIES; FEMALE; HEALTHY VOLUNTEERS; HUMANS; OXIDATIVE STRESS; YOUNG ADULT;

EID: 84945480218     PISSN: 02763478     EISSN: 1098108X     Source Type: Journal    
DOI: 10.1002/eat.22443     Document Type: Review

References (72)

1. Strober M, Freeman R, Morrell W., The long-term course of severe anorexia nervosa in adolescents: Survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study. Int J Eat Disord 1997; 22: 339-360.
2. Smink FR, van Hoeken D, Hoek HW., Epidemiology of eating disorders: Incidence, prevalence and mortality rates. Curr Psychiatry Rep 2012; 14: 406-414.
3. Micali N, Hagberg KW, Petersen I, Treasure JL., The incidence of eating disorders in the UK in 2000-2009: Findings from the General Practice Research Database. BMJ Open 2013; 3:e002646.
4. Hinney A, Volckmar AL., Genetics of eating disorders. Curr Psychiatry Rep 2013; 15: 423.
5. Kim Y, Trace SE, Crowley JJ, Brownley KA, Hamer, RM, Pisetsky DS, et al., Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa. Psychiatry Res 2013; 210: 287-293.
6. Favaro A, Tenconi E, Santonastaso P., The interaction between perinatal factors and childhood abuse in the risk of developing anorexia nervosa. Psychol Med 2010; 40: 657-665.
7. Halmi KA, Bellace D, Berthod S, Ghosh S, Berrettini, W, Brandt HA, et al., An examination of early childhood perfectionism across anorexia nervosa subtypes. Int J Eat Disord 2012; 45: 800-807.
8. Moyano D, Sierra C, Brandi N, Artuch R, Mira A, García-Tornel S, et al., Antioxidant status in anorexia nervosa. Int J Eat Disord 1999; 25: 99-103.
9. Curatola G, Camilloni MA, Vignini A, Nanetti L, Boscaro M, Mazzanti L., Chemical-physical properties of lipoproteins in anorexia nervosa. Eur J Clin Invest 2004; 34: 747-751.
10. Agnello E, Malfi G, Costantino AM, Massarenti P, Pugliese, M, Fortunati N, et al., Tumour necrosis factor alpha and oxidative stress as maintaining factors in the evolution of anorexia nervosa. Eat Weight Disord 2012; 17: e194-e199.
11. Hovatta I, Juhila J, Donner J., Oxidative stress in anxiety and comorbid disorders. Neurosci Res 2010; 68: 261-275.
12. Aksenova MV, Aksenov MY, Mactutus CF, Booze RM., Cell culture models of oxidative stress and injury in the central nervous system. Curr Neurovasc Res 2005; 2: 73-89.
13. Berk M, Ng F, Dean O, Dodd S, Bush AI., Glutathione: A novel treatment target in psychiatry. Trend Pharmacol Sci 2008; 29: 346-351.
14. Filomeni G, Ciriolo MR., Redox control of apoptosis: An update. Antioxid Redox Signal 2006; 8: 2187-2192.
15. Flatow J, Buckley P, Miller BJ., Meta-analysis of oxidative stress in schizophrenia. Biol Psychiatry 2013; 74: 400-409.
16. Brown NC, Andreazza AC, Young LT., An updated meta-analysis of oxidative stress markers in bipolar disorder. Psychiatry Res 2014; 218: 61-68.
17. Dostálová I, Kaválková P, Papezová H, Domluvilová D, Zikán V, Haluzík M., Association of macrophage inhibitory cytokine-1 with nutritional status, body composition and bone mineral density in patients with anorexia nervosa: The influence of partial realimentation. Nutr Metab (Lond) 2010; 7: 34.
18. Lapidus KA, Gabbay V, Mao X, Johnson A, Murrough JW, Mathew SJ, Shungu DC., In vivo (1)H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder. Neurosci Lett 2014; 569: 74-79.
19. Dwyer DS, Horton RY, Aamodt EJ., Role of the evolutionarily conserved starvation response in anorexia nervosa. Mol Psychiatry 2011; 16: 595-603.
20. Morales AE, Pérez-Jiménez A, Hidalgo MC, Abellán E, Cardenete G., Oxidative stress and antioxidant defenses after prolonged starvation in Dentex dentex liver. Comp Biochem Physiol C Toxicol Pharmacol 2004; 139: 153-161.
21. Talarowska M, Bobińska K, Zajączkowska M, Su KP, Maes M, Gałecki P., Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders. Med Sci Monit 2014; 20: 110-115.
22. Vignini A, D'Angelo M, Nanetti L, Camilloni MA, Cester, AM, Faloia E, et al., Anorexia nervosa: A role for L-arginine supplementation in cardiovascular risk factors?. Int J Eat Disord 2010; 43: 464-471.
23. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, Initiative S., The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. PLoS Med 2007; 4: e296.
24. Mohrer D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. J Clin Epidem 2009; 62: 1006-1012.
25. Case T, Lemieux S, Kennedy SH, Lewis GF., Elevated plasma lipids in patients with binge eating disorders are found only in those who are anorexic. Int J Eat Disord 1999; 25: 187-193.
26. Matzkin V, Slobodianik N, Pallaro A, Bello M, Geissler C., Risk factors for cardiovascular disease in patients with anorexia nervosa. Int J Psychiatr Nurs Res 2007; 13: 1531-1545.
27. Misra M, Miller KK, Tsai P, Stewart V, End, A, Freed N, et al., Uncoupling of cardiovascular risk markers in adolescent girls with anorexia nervosa. J Pediatr 2006; 149: 763-769.
28. Ohwada R, Hotta M, Oikawa S, Takano K., Etiology of hypercholesterolemia in patients with anorexia nervosa. Int J Eat Disord 2006; 39: 598-601.
29. Rigaud D, Tallonneau I, Vergès B., Hypercholesterolaemia in anorexia nervosa: Frequency and changes during refeeding. Diabetes Metab 2009; 35: 57-63.
30. Sánchez-Muniz FJ, Marcos A, Varela P., Serum lipids and apolipoprotein B values, blood pressure and pulse rate in anorexia nervosa. Eur J Clin Nutr 1991; 45: 33-36.
31. Weinbrenner T, Züger M, Jacoby GE, Herpertz S, Liedtke, R, Sudhop T, et al., Lipoprotein metabolism in patients with anorexia nervosa: A case-control study investigating the mechanisms leading to hypercholesterolaemia. Br J Nutr 2004; 91: 959-969.
32. Umeki S., Biochemical abnormalities of the serum in anorexia nervosa. J Nerv Ment Dis 1988; 176: 503-506.
33. Vannacci A, Ravaldi C, Giannini L, Rotella CM, Masini E, Faravelli C, Ricca V., Increased nitric oxide production in eating disorders. Neurosci Lett 2006; 399: 230-233.
34. Os̈więcimska J, Ziora K, Ziora D, Machura E, Smerdziński, S, Pys̈-Spychała M, et al., Elevated levels of exhaled nitric oxide in patients with anorexia nervosa. Eur Child Adolesc Psychiatry 2014; 23: 845-850.
35. Fernández-Soto ML, González-Jiménez A, Chamorro-Fernández M, Leyva-Martínez S., Clinical and hormonal variables related to bone mass loss in anorexia nervosa patients. Vitam Horm 2013; 92: 259-269.
36. Haluzík M, Kábrt J, Nedvídková J, Svobodová J, Kotrlíková E, Papezová H., Relationship of serum leptin levels and selected nutritional parameters in patients with protein-caloric malnutrition. Nutrition 1999; 15: 829-833.
37. Haluzík M, Papezová M, Nedvídková J, Kábrt J., Serum leptin levels in patients with anorexia nervosa before and after partial refeeding, relationships to serum lipids and biochemical nutritional parameters. Physiol Res 1999; 48: 197-202.
38. Lawson EA, Misra M, Meenaghan E, Rosenblum L, Donoho, DA, Herzog D, et al., Adrenal glucocorticoid and androgen precursor dissociation in anorexia nervosa. J Clin Endocrinol Metab 2009; 94: 1367-1371.
39. Nova E, Lopez-Vidriero I, Varela P, Toro O, Casas JJ, Marcos AA., Indicators of nutritional status in restricting-type anorexia nervosa patients: A 1-year follow-up study. Clin Nutr 2004; 23: 1353-1359.
40. Pascal N, Amouzou EK, Sanni A, Namour F, Abdelmouttaleb I, Vidailhet M, et al., Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus. Am J Clin Nutr 2002; 76: 239-244.
41. Rodrigues Pereira N, Bandeira Moss M, Assumpção CR, Cardoso CB, Mann GE, Brunini TM, et al., Oxidative stress, l-arginine-nitric oxide and arginase pathways in platelets from adolescents with anorexia nervosa. Blood Cells Mol Dis 2010; 44: 164-168.
42. Smith G, Robinson PH, Fleck A., Serum albumin distribution in early treated anorexia nervosa. Nutrition 1996; 12: 677-684.
43. Van Binsbergen CJ, Odink J, Van den Berg H, Koppeschaar H, Coelingh Bennink HJ., Nutritional status in anorexia nervosa: Clinical chemistry, vitamins, iron and zinc. Eur J Clin Nutr 1988; 42: 929-937.
44. Zepf FD, Sungurtekin I, Glass F, Elstrodt L, Peetz D, Hintereder G, et al., Differences in serum zn levels in acutely ill and recovered adolescents and young adults with anorexia nervosa-A pilot study. Eur Eat Disord Rev 2012; 20: 203-210.
45. Zenger F, Russmann S, Junker E, Wüthrich C, Bui MH, Lauterburg BH., Decreased glutathione in patients with anorexia nervosa. Risk factor for toxic liver injury? Eur J Clin Nutr 2004; 58: 238-243.
46. Boland B, Beguin C, Zech F, Desager JP, Lambert M., Serum beta-carotene in anorexia nervosa patients: A case-control study. Int J Eat Disord 2001; 30: 299-305.
47. Delporte ML, Brichard SM, Hermans MP, Beguin C, Lambert M., Hyperadiponectinaemia in anorexia nervosa. Clin Endocrinol (Oxf) 2003; 58: 22-29.
48. Langan SM, Farrell PM, Vitamin E., vitamin A and essential fatty acid status of patients hospitalized for anorexia nervosa. Am J Clin Nutr 1985; 41: 1054-1060.
49. Contois JH, McConnell JP, Sethi AA, Csako G, Devaraj S, Hoefner DM, et al., Apolipoprotein B and cardiovascular disease risk: Position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem 2009; 55: 407-419.
50. Jacobson TA., Opening a new lipid "apo-thecary": Incorporating apolipoproteins as potential risk factors and treatment targets to reduce cardiovascular risk. Mayo Clin Proc 2011; 86: 762-780.
51. Bolzetta F, Veronese N, Manzato E, Sergi G., Tophaceous gout in the elderly: A clinical case review. Clin Rheumatol 2012; 31: 1127-1132.
52. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G., Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med 2009; 266: 558-570.
53. Feig DI, Kang DH, Johnson RJ., Uric acid and cardiovascular risk. N Engl J Med 2008; 359: 1811-1821.
54. Kim BJ, Baek S, Ahn SH, Kim SH, Jo, MW, Bae SJ, et al., Higher serum uric acid as a protective factor against incident osteoporotic fractures in Korean men: A longitudinal study using the National Claim Registry. Osteoporos Int 2014; 25: 1837-1844.
55. Krantz MJ, Lee D, Donahoo WT, Mehler PS., The paradox of normal serum albumin in anorexia nervosa: A case report. Int J Eat Disord 2005; 37: 278-280.
56. Herbert V., Prooxidant effects of antioxidant vitamins. Int J Nutr 1996; 126: 1197S-200S.
57. Halliwell B., Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence? Lancet 1994; 344: 721-724.
58. Paiva SA, Russell RM., Beta-carotene and other carotenoids as antioxidants. J Am Coll Nutr 1999; 18: 426-433.
59. Curran-Celentano J, Erdman JW, Nelson RA, Grater SJ., Alterations in vitamin A and thyroid hormone status in anorexia nervosa and associated disorders. Am J Clin Nutr 1985; 42: 1183-1191.
60. Robboy MS, Sato AS, Schwabe AD., The hypercarotenemia in anorexia nervosa: A comparison of vitamin A and carotene levels in various forms of menstrual dysfunction and cachexia. Am J Clin Nutr 1974; 27: 362-367.
61. Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E., The antioxidant properties of serum albumin. FEBS Lett 2008; 582: 1783-1787.
62. Steinhausen HC., Treatment and outcome of adolescent anorexia nervosa. Horm Res 1995; 43: 168-170.
63. Jacob RA, Burri BJ., Oxidative damage and defense. Am J Clin Nutr 1996; 63: 985S-990S.
64. Anzengruber D, Klump KL, Thornton L, Brandt H, Crawford S, Fichter MM, et al., Smoking in eating disorders. Eat Behav 2006; 7: 291-299.
65. Grassi D, Desideri G, Ferri L, Aggio A, Tiberti S, Ferri C., Oxidative stress and endothelial dysfunction: Say NO to cigarette smoking! Curr Pharm Des 2010; 16: 2539-2550.
66. Matsuda M, Shimomura I., Increased oxidative stress in obesity: Implications for metabolic sybdrome, diabetes, hyperthension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract 2013; 7: e330-e341.
67. Sendur OF, Turan Y, Tastaban E, Serter M., Antioxidant status in patients with osteoporosis: A controlled study. Joint Bone Spine 2009; 76: 514-518.
68. Veronese N, Solmi M, Rizza W, Manzato E, Sergi G, Santonastaso P, Caregaro L, Favaro A, Correll CU,. Vitamin D status in anorexia nervosa: A meta-analysis. Int J Eat Disord 2014 Nov 29. doi: 10.1002/eat.22370. [Epub ahead of print] PubMed PMID: 25445242.
69. Rizza W, Veronese N, Fontana L., What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Res Rev 2014; 13: 38-45.
70. Steinhausen HC., The outcome of anorexia nervosa in the 20th century. Am J Psychiatry 2002; 159: 1284-1293.
71. Galecki P, Szemraj J, Zboralski K, Florkowski A, Lewinski A., Relation between functional polymorphism of catalase gene (-262C>T) and recurrent depressive disorder. Neuro Endocrinol Lett 2009; 30: 357-362.
72. Jiménez-Fernández S, Gurpegui M, Díaz-Atienza F, Pérez-Costillas L, Gerstenberg M, Correll CU., Oxidative stress and antioxidant parameters in patients with major depressive disorder and after antidepressant treatment: Results from a meta-analysis. J Clin Psychiatry, in press.