Lipoprotein metabolism in patients with anorexia nervosa: A case - Control study investigating the mechanisms leading to hypercholesterolaemia

British Journal of Nutrition

Volumn 91, Issue 6, 2004, Pages 959-969

  Weinbrenner, T ^a   Zuger M ^b   Jacoby, G E ^b   Herpertz, S ^c   Liedtke, R ^a   Sudhop, T ^a   Gouni Berthold, I ^a   Axelson, M ^d   Berthold, Heiner K ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Klinik Am Korso   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Anorexia nervosa; Hypercholesterolaemia; Lipoprotein metabolism

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL DERIVATIVE; FAT; GLYCEROL; LATHOSTEROL; LIOTHYRONINE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROID HORMONE; THYROXINE; TRIACYLGLYCEROL; HORMONE; VERY LOW DENSITY LIPOPROTEIN;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; ARTICLE; BILE ACID SYNTHESIS; BINGE EATING DISORDER; BODY FAT; BODY MASS; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HUMAN; HYPERCHOLESTEROLEMIA; LIPOLYSIS; MULTIPLE REGRESSION; PATHOPHYSIOLOGY; PROTEIN METABOLISM; BLOOD; BODY COMPOSITION; CLINICAL TRIAL; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PHYSIOLOGY; REGRESSION ANALYSIS;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; BODY COMPOSITION; CASE-CONTROL STUDIES; CHOLESTEROL; CHOLESTEROL, LDL; FEMALE; HORMONES; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, VLDL; MIDDLE AGED; REGRESSION ANALYSIS;

EID: 3142514574     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN20041151     Document Type: Article

References (44)

1. Affenito SG, Lammi-Keefe CJ, Vogel S, Backstrand JR, Welch GW & Adams CH (1997) Women with insulin-dependent diabetes mellitus (IDDM) complicated by eating disorders are at risk for exacerbated alterations in lipid metabolism. Eur J Clin Nutr 51, 462-466.
2. Angelin B (1991) Regulation of hepatic cholesterol metabolism in man. Ann Med 23, 177-180.
3. Arden MR, Weiselberg EC, Nussbaum MP, Shenker IR & Jacobson MS (1990) Effect of weight restoration on the dyslipoproteinemia of anorexia nervosa. J Adolesc Health Care 11, 199-202.
4. Auwerx J & Staels B (1998) Leptin. Lancet 351, 737-742.
5. Axelson M, Aly A & Sjovall J (1988) Levels of 7 alpha-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man. FEBS Lett 239, 324-328.
6. Bertolotti M, Spady DK & Dietschy JM (1995) Regulation of hepatic cholesterol metabolism in the rat in vivo: effect of a synthetic fat-free diet on sterol synthesis and low-density lipoprotein transport. Biochim Biophys Acta 1255, 293-300.
7. Björkhem I, Miettinen T, Reihner E, Ewerth S, Angelin B & Einarsson K (1987) Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. J Lipid Res 28, 1137-1143.
8. Blendis LM & Crisp AH (1968) Serum cholesterol levels in anorexia nervosa. Postgrad Med J 44, 327-330.
9. Brown MS & Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232, 34-47.
10. Case T, Lemieux S, Kennedy SH & Lewis GF (1999) Elevated plasma lipids in patients with binge eating disorders are found only in those who are anorexic. Int J Eat Disord 25, 187-193.
11. Crisp AH, Blendis LM & Pawan GL (1968) Aspects of fat metabolism in anorexia nervosa. Metabolism 17, 1109-1118.
12. Crisp AH, Lace A, Blendis LM & Pawan GL (1967) Some aspects of fat metabolism in anorexia nervosa. Proc Nutr Soc 26, 32-35.
13. de Bruin TW, van Barlingen H, Linde-Sibenius TM, van Vuurst de Vries AR, Akveld MJ & Erkelens DW (1993) Lipoprotein(a) and apolipoprotein B plasma concentrations in hypothyroid, euthyroid, and hyperthyroid subjects. J Clin Endocrinol Metab 76, 121-126.
14. Diekman MJ, Anghelescu N, Endert E, Bakker O & Wiersinga WM (2000) Changes in plasma low-density lipoprotein (LDL)- and high-density lipoprotein cholesterol in hypo- and hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes. J Clin Endocrinol Metab 85, 1857-1862.
15. Duvillard L, Florentin E, Lizard G, Petit JM, Galland F, Monier S, Gambert P & Verges B (2003) Cell surface expression of LDL receptor is decreased in type 2 diabetic patients and is normalized by insulin therapy. Diabetes Care 26, 1540-1544.
16. Feillet F, Feillet-Choloudray C, Bard JM, Parra HJ, Favre E, Kabuth B, Fruchart JC & Vidailhet M (2000) Plasma cholesterol and endogenous cholesterol synthesis during refeeding in anorexia nervosa. Clin Chim Acta 294, 45-56.
17. Gower BA, Weinsier RL, Jordan JM, Hunter GR & Desmond R (2002) Effects of weight loss on changes in insulin sensitivity and lipid concentrations in premenopausal African American and white women. Am J Clin Nutr 76, 923-927.
18. Halmi KA & Falk JR (1981) Common physiological changes in anorexia nervosa. Int J Eat Disord 1, 27.
19. Homma Y, Homma K, Iizuka S & Iigaya K (2002) A case of anorexia nervosa with severe hyperlipoproteinemia. Int J Eat Disord 32, 121-124.
20. Kaye WH, Weltzin TE, Hsu LK, McConaha CW & Bolton B (1993) Amount of calories retained after binge eating and vomiting. Am J Psychiatry 150, 969-971.
21. Kempen HJ, Glatz JF, Gevers Leuven JA, van der Voort HA & Katan MB (1988) Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res 29, 1149-1155.
22. Klinefelter HF (1965) Hypercholesterolemia in anorexia nervosa. J Clin Endocrinol Metab 25, 1520-1521.
23. Lacombe CR, Corraze GR, Nibbelink MM, Boulze D, Douste-Blazy P & Camare R (1986) Effects of a low-energy diet associated with egg supplementation on plasma cholesterol and lipoprotein levels in normal subjects: results of a cross-over study. Br J Nutr 56, 561-575.
24. Lin DS & Connor WE (1980) The long term effects of dietary cholesterol upon the plasma lipids, lipoproteins, cholesterol absorption, and the sterol balance in man: the demonstration of feedback inhibition of cholesterol biosynthesis and increased bile acid excretion. J Lipid Res 21, 1042-1052.
25. Mazzella G, Cipolla A, Villanova N, Polimeni C, Sipahi A, Parini P, Fusaroli P, Festi D & Roda E (1995) Changes in biliary lipid secretion and cholic acid kinetics induced by diet, diet plus simvastatin and diet plus ursodeoxycholic acid in obese subjects. Ital J Gastroenterol 27, 441-445.
26. Mehler PS, Lezotte D & Eckel R (1998) Lipid levels in anorexia nervosa. Int J Eat Disord 24, 217-221.
27. Miettinen TA (1968) Fecal steroid excretion during weight reduction in obese patients with hyperlipidemia. Clin Chim Acta 19, 341-344.
28. Miettinen TA, Tilvis RS & Kesaniemi YA (1990) Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 131, 20-31.
29. Montoye HJ, Epstein FH & Kjelsberg MO (1966) Relationship between serum cholesterol and body fatness. An epidemiologic study. Am J Clin Nutr 18, 397-406.
30. Mordasini R, Klose G & Greten H (1978) Secondary type II hyperlipoproteinemia in patients with anorexia nervosa. Metabolism 27, 71-79.
31. Nestel PJ (1974) Cholesterol metabolism in anorexia nervosa and hypercholesterolemia. J Clin Endocrinol Metab 38, 325-328.
32. Phinney SD, Tang AB, Waggoner CR, Tezanos-Pinto RG & Davis PA (1991) The transient hypercholesterolemia of major weight loss. Am J Clin Nutr 53, 1404-1410.
33. Regnstrom J, Nilsson J, Tornvall P, Landou C & Hamsten A (1992) Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 339, 1183-1186.
34. Sanchez-Muniz FJ, Marcos A & Varela P (1991) Serum lipids and apolipoprotein B values, blood pressure and pulse rate in anorexia nervosa. Eur J Clin Nutr 45, 33-36.
35. Savendahl L & Underwood LE (1999) Fasting increases serum total cholesterol, LDL cholesterol and apolipoprotein B in healthy, nonobese humans. J Nutr 129, 2005-2008.
36. Stone NJ (1994) Secondary causes of hyperlipidemia. Med Clin North Am 78, 117-141.
37. Sullivan PF, Gendall KA, Bulik CM, Carter FA & Joyce PR (1998) Elevated total cholesterol in bulimia nervosa. Int J Eat Disord 23, 425-432.
38. Tamai H, Mori K, Matsubayashi S, Kiyohara K, Nakagawa T, Okimura MC, Walter RM Jr, Kumagai LF & Nagataki S (1986) Hypothalamic-pituitary-thyroidal dysfunctions in anorexia nervosa. Psychother Psychosom 46, 127-131.
39. Teng B, Thompson GR, Sniderman AD, Forte TM, Krauss RM & Kwiterovich PO Jr (1983) Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia. Proc Natl Acad Sci USA 80, 6662-6666.
40. Vaisman N, Sklan D & Dayan Y (1990) Effect of moderate semi-starvation on plasma lipids. Int J Obes 14, 989-996.
41. van der Wal AM, Bakker O & Wiersinga WM (1998) The decrease of liver LDL receptor mRNA during fasting is related to the decrease in serum T3. Int J Biochem Cell Biol 30, 209-215.
42. Wiegratz I, Jung-Hoffmann C, Gross W & Kuhl H (1998) Effect of two oral contraceptives containing ethinyl estradiol and gestodene or norgestimate on different lipid and lipoprotein parameters. Contraception 58, 83-91.
43. Zipfel S, Lowe B, Reas DL, Deter HC & Herzog W (2000) Long-term prognosis in anorexia nervosa: lessons from a 21-year follow-up study. Lancet 355, 721-722.
44. Zoppi G, Cinquetti M & Luciano A (1993) Hypercholesterolemia in anorexia nervosa: probable cause. Acta Med Auxol 25, 201.