First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 70, Issue 11, 2015, Pages 1406-1412

  Dubois, A E J ^a   Pagliarani, G ^b   Brouwer, R M ^a   Kollen, B J ^c   Dragsted, L O ^d   Eriksen, F D ^e   Callesen, O ^f   Gilissen, L J W J ^b   Krens, F A ^b   Visser, R G F ^b   Smulders, M J M ^b   Vlieg Boerstra, B J ^a   Flokstra De Blok, B J ^c   Van De Weg, W E ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^f AARHUS UNIVERSITY   (Denmark)

Author keywords

apple allergy; food allergy; food challenge; genetically modified food; RNAi

Indexed keywords

MAL D 1 PROTEIN; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; MALD1 PROTEIN, MALUS DOMESTICA; PLANT ANTIGEN; VEGETABLE PROTEIN;

ADULT; ALLERGENICITY; APPLE; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MODIFICATION; DOWN REGULATION; FEMALE; FOOD ALLERGY; FOOD INTAKE; GENE EXPRESSION; GENE SILENCING; GENETICALLY MODIFIED FOOD; HUMAN; MALE; PRIORITY JOURNAL; PROVOCATION TEST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK REDUCTION; RNA INTERFERENCE; UPREGULATION; VISUAL ANALOG SCALE; ADVERSE EFFECTS; FOOD HYPERSENSITIVITY; GENETICS; IMMUNOLOGY; MALUS; TRANSGENIC PLANT; YOUNG ADULT;

ADULT; ANTIGENS, PLANT; DOWN-REGULATION; FEMALE; FOOD HYPERSENSITIVITY; GENE EXPRESSION; GENE SILENCING; HUMANS; MALE; MALUS; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; YOUNG ADULT;

EID: 84945478968     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12684     Document Type: Article

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