Chondrogenically primed mesenchymal stem cell-seeded alginate hydrogels promote early bone formation in critically-sized defects

European Polymer Journal

Volumn 72, Issue , 2015, Pages 464-472

  Cunniffe, G M ^a   Vinardell, T ^b   Thompson, E M ^a,c   Daly, A C ^a   Matsiko, A ^a,c   O'Brien, F J ^a,c   Kelly, D J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Alginate; Degradation; Endochondral ossification; Large bone regeneration

Indexed keywords

ALGINATE; BIOCOMPATIBILITY; BONE; CARTILAGE; CELL CULTURE; DEFECTS; DEGRADATION; FLOWCHARTING; HISTOLOGY; STEM CELLS; TISSUE; TISSUE REGENERATION;

ALGINATE HYDROGELS; BONE MARROW-DERIVED MESENCHYMAL STEM CELLS; BONE REGENERATION; CARTILAGE TISSUES; DEGRADATION KINETICS; ENDOCHONDRAL OSSIFICATION; ENGINEERED TISSUES; MESENCHYMAL STEM CELL;

HYDROGELS;

EID: 84945467894     PISSN: 00143057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpolymj.2015.07.021     Document Type: Article

References (46)

1. G.J. Meijer, and et al. Cell-based bone tissue engineering PLoS Med. 4 2 2007 0260 0264
2. R. Langer Tissue engineering Mol. Ther. 1 1 2000 12 15
3. F.G. Lyons, and et al. The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs Biomaterials 31 35 2010 9232 9243
4. M.I. Santos, and R.L. Reis Vascularization in bone tissue engineering: physiology, current strategies, major hurdles and future challenges Macromol. Biosci. 10 1 2010 12 27
5. E.M. Thompson, and et al. Recapitulating endochondral ossification: a promising route to in vivo bone regeneration J. Tissue Eng. Regen. Med. 2014
6. E.J. Mackie, and et al. Endochondral ossification: how cartilage is converted into bone in the developing skeleton Int. J. Biochem. Cell Biol. 40 1 2008 46 62
7. E. Farrell, and et al. Chondrogenic priming of human bone marrow stromal cells: a better route to bone repair? Tissue Eng. Part C Methods 15 2 2009 285 295
8. C. Scotti, and et al. Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering Proc. Natl. Acad. Sci. USA 107 16 2010 7251 7256
9. C. Scotti, and et al. Engineering of a functional bone organ through endochondral ossification Proc. Natl. Acad. Sci. USA 110 10 2013 3997 4002
10. J. van der Stok, and et al. Chondrogenically differentiated mesenchymal stromal cell pellets stimulate endochondral bone regeneration in critical-sized bone defects Eur. Cell Mater. 27 2014 137 148
11. J.I. Huang, and et al. Lunate arthroplasty with autologous mesenchymal stem cells in a rabbit model J. Bone Joint Surg. - Ser. A 88 4 2006 744 752
12. E. Farrell, and et al. In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells BMC Muscle. Disorders 12 31 2011
13. D. Gawlitta, and et al. Modulating endochondral ossification of multipotent stromal cells for bone regeneration Tissue Eng. - Part B: Rev. 16 4 2010 385 395
14. P. Janicki, and et al. Chondrogenic pre-induction of human mesenchymal stem cells on β-TCP: enhanced bone quality by endochondral heterotopic bone formation Acta Biomater. 6 8 2010 3292 3301
15. N. Harada, and et al. Bone regeneration in a massive rat femur defect through endochondral ossification achieved with chondrogenically differentiated MSCs in a degradable scaffold Biomaterials 35 27 2014 7800 7810
16. R. Santoro, and et al. Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing Biomaterials 31 34 2010 8946 8952
17. E.J. Sheehy, C.T. Buckley, and D.J. Kelly Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions J. Tissue Eng. Regen. Med. 5 9 2011 747 758
18. T. Mesallati, C.T. Buckley, and D.J. Kelly A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes Tissue Eng. - Part C: Methods 20 1 2014 52 63
19. C.T. Buckley, S.D. Thorpe, and D.J. Kelly Engineering of large cartilaginous tissues through the use of microchanneled hydrogels and rotational culture Tissue Eng. - Part A 15 11 2009 3213 3220
20. J.L. Drury, and D.J. Mooney Hydrogels for tissue engineering: scaffold design variables and applications Biomaterials 24 24 2003 4337 4351
21. R.M. Coleman, N.D. Case, and R.E. Guldberg Hydrogel effects on bone marrow stromal cell response to chondrogenic growth factors Biomaterials 28 12 2007 2077 2086
22. E. Caló, and V.V. Khutoryanskiy Biomedical applications of hydrogels: a review of patents and commercial products Eur. Polym. J. 2014 Available online 28 November 2014
23. A.D. Augst, H.J. Kong, and D.J. Mooney Alginate hydrogels as biomaterials Macromol. Biosci. 6 8 2006 623 633
24. K.Y. Lee, and D.J. Mooney Alginate: properties and biomedical applications Prog. Polym. Sci. 37 1 2012 106 126
25. J. Sun, and H. Tan Alginate-based biomaterials for regenerative medicine applications Materials 6 4 2013 1285 1309
26. K. Ma, and et al. Variations in chondrogenesis of human bone marrow-derived mesenchymal stem cells in fibrin/alginate blended hydrogels Acta Biomater. 8 10 2012 3754 3764
27. H.A. Awad, and et al. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds Biomaterials 25 16 2004 3211 3222
28. M.M. Pleumeekers, and et al. The in vitro and in vivo capacity of culture-expanded human cells from several sources encapsulated in alginate to form cartilage Eur. Cell Mater. 27 2014 264 280
29. X. Cai, and et al. Ectopic osteogenesis and chondrogenesis of bone marrow stromal stem cells in alginate system Cell Biol. Int. 31 8 2007 776 783
30. E.J. Sheehy, and et al. Engineering cartilage or endochondral bone: a comparison of different naturally derived hydrogels Acta Biomater. 13 2015 245 253
31. Y.M. Kolambkar, and et al. An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects Biomaterials 32 1 2011 65 74
32. C.A. Simmons, and et al. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells Bone 35 2 2004 562 569
33. E.J. Sheehy, and et al. Tissue engineering whole bones through endochondral ossification: regenerating the distal phalanx BioRes. Open Access 4 1 2015 229 241
34. E.J. Sheehy, and et al. Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation PLoS One 9 3 2014 e90716
35. T.M. Filion, and et al. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats Tissue Eng. Part A 17 3-4 2011 503 511
36. T.T. Lau, and et al. Inducing ossification in an engineered 3D scaffold-free living cartilage template Biomaterials 33 33 2012 8406 8417
37. S.M. Oliveira, and et al. Engineering endochondral bone: in vivo studies Tissue Eng. - Part A 15 3 2009 635 643
38. P.E. Bourgine, and et al. Osteoinductivity of engineered cartilaginous templates devitalized by inducible apoptosis Proc. Natl. Acad. Sci. 111 49 2014 17426 17431
39. O. Jeon, and et al. Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties Biomaterials 30 14 2009 2724 2734
40. S.C.-N. Chang, and et al. Cranial repair using BMP-2 gene engineered bone marrow stromal cells1 J. Surg. Res. 119 1 2004 85 91
41. J. Venkatesan, and et al. Alginate composites for bone tissue engineering: a review Int. J. Biol. Macromol. 72 2015 269 281
42. E. Alsberg, and et al. Regulating bone formation via controlled scaffold degradation J. Dental Res. 82 11 2003 903 908
43. E. Alsberg, and et al. Engineering growing tissues Proc. Natl. Acad. Sci. 99 19 2002 12025 12030
44. T. Boontheekul, H.-J. Kong, and D.J. Mooney Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution Biomaterials 26 15 2005 2455 2465
45. M. Mumme, and et al. Interleukin-1β modulates endochondral ossification by human adult bone marrow stromal cells Eur. Cells Mater. 24 2012 224 236
46. T. Fuji, and et al. Octacalcium phosphate-precipitated alginate scaffold for bone regeneration Tissue Eng. Part A 15 11 2009 3525 3535