Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing

Biomaterials

Volumn 31, Issue 34, 2010, Pages 8946-8952

  Santoro, Rosaria ^a   Olivares, Andy L ^b   Brans, Gerben ^c   Wirz, Dieter ^d   Longinotti, Cristina ^e   Lacroix, Damien ^b   Martin, Ivan ^a   Wendt, David ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

^c Deer Park Business Centre   (Netherlands)

^d UNIVERSITY OF BASEL   (Switzerland)

^e Fidia Advanced Biopolymers   (Italy)

Author keywords

Bioreactor; Cartilage repair; Computational fluid dynamics; Regenerative medicine; Scale up; Tissue engineering

Indexed keywords

BIOMECHANICAL PROPERTIES; CARTILAGE DEFECTS; CARTILAGE REPAIR; CLINICAL TREATMENTS; COMPUTATIONAL FLUID; COMPUTATIONAL FLUID DYNAMICS MODELS; FLOW PROFILE; HUMAN CARTILAGE; HUMAN CHONDROCYTES; HUMAN KNEE JOINT; MANUFACTURING SYSTEM; PERFUSION BIOREACTOR SYSTEMS; PRODUCTION PROCEDURE; REGENERATIVE MEDICINE; SCALE-UP; SURGICAL PROCEDURES; TOTAL JOINT REPLACEMENT; UNIFORM DISTRIBUTION;

BIOCONVERSION; BIOMECHANICS; BIOREACTORS; COMPUTATIONAL FLUID DYNAMICS; ENGINEERING; FLUID DYNAMICS; FLUIDS; HISTOLOGY; IMPLANTS (SURGICAL); JOINT PROSTHESES; JOINTS (ANATOMY); LIGAMENTS; SURGERY; TISSUE ENGINEERING;

CARTILAGE;

ADULT; ARTICLE; AUTOMATION; BIOENGINEERING; BIOMECHANICS; BIOREACTOR; BIOREACTOR EQUIPMENT; CARTILAGE CELL; CARTILAGE GRAFT; CARTILAGE INJURY; CELL CULTURE; COMPUTATIONAL FLUID DYNAMICS; HUMAN; HUMAN CELL; JOINT PROSTHESIS; LARGE SCALE PRODUCTION; OSTEOARTHRITIS; PRIORITY JOURNAL; TISSUE GROWTH;

ARTHROPLASTY; BIOMECHANICS; BIOREACTORS; CARTILAGE; COMPUTER SIMULATION; GLYCOSAMINOGLYCANS; HUMANS; JOINTS; PERFUSION; RHEOLOGY; TISSUE ENGINEERING;

EID: 77957312861     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.08.009     Document Type: Article

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