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Volumn 125, Issue 20, 2015, Pages e14-e22

The tumor virus landscape of AIDS-related lymphomas

Author keywords

Heterogeneous viral gene expression suggests that variable host immunosurveillance of ebv latency may influence lymphomagenesis.; Revealing the oncogenic herpesvirus ebv as the sole detected infectious agent.; We evaluated a cohort of arl samples for known and novel tumor viruses

Indexed keywords

VIRUS ANTIGEN;

EID: 84945466762     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-11-599951     Document Type: Article
Times cited : (65)

References (47)
  • 1
    • 33646413672 scopus 로고    scopus 로고
    • The global health burden of infectionassociated cancers in the year 2002
    • Parkin DM. The global health burden of infectionassociated cancers in the year 2002. Int J Cancer. 2006;118(12):3030-3044.
    • (2006) Int J Cancer , vol.118 , Issue.12 , pp. 3030-3044
    • Parkin, D.M.1
  • 2
    • 70449368710 scopus 로고    scopus 로고
    • HIV infection and the risk of cancers with and without a known infectious cause
    • Silverberg MJ, Chao C, Leyden WA, et al. HIV infection and the risk of cancers with and without a known infectious cause. AIDS. 2009;23(17): 2337-2345.
    • (2009) AIDS , vol.23 , Issue.17 , pp. 2337-2345
    • Silverberg, M.J.1    Chao, C.2    Leyden, W.A.3
  • 3
    • 0036547521 scopus 로고    scopus 로고
    • AIDS malignancies in the era of highly active antiretroviral therapy
    • Gates AE, Kaplan LD. AIDS malignancies in the era of highly active antiretroviral therapy. Oncology (Williston Park). 2002;16(4):441-451.
    • (2002) Oncology (Williston Park) , vol.16 , Issue.4 , pp. 441-451
    • Gates, A.E.1    Kaplan, L.D.2
  • 4
    • 34347323902 scopus 로고    scopus 로고
    • Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: A meta-analysis
    • Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet. 2007; 370(9581):59-67.
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 59-67
    • Grulich, A.E.1    Van Leeuwen, M.T.2    Falster, M.O.3    Vajdic, C.M.4
  • 5
    • 0028588064 scopus 로고
    • Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    • Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266(5192):1865-1869.
    • (1994) Science , vol.266 , Issue.5192 , pp. 1865-1869
    • Chang, Y.1    Cesarman, E.2    Pessin, M.S.3
  • 6
    • 39749113080 scopus 로고    scopus 로고
    • Clonal integration of a polyomavirus in human Merkel cell carcinoma
    • Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096-1100.
    • (2008) Science , vol.319 , Issue.5866 , pp. 1096-1100
    • Feng, H.1    Shuda, M.2    Chang, Y.3    Moore, P.S.4
  • 7
    • 77955057193 scopus 로고    scopus 로고
    • Changing patterns of cancer incidence in the early- and late-HAART periods: The Swiss HIV Cohort Study
    • Swiss HIV Cohort Study
    • Franceschi S, Lise M, Clifford GM, et al; Swiss HIV Cohort Study. Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study. Br J Cancer. 2010; 103(3):416-422.
    • (2010) Br J Cancer , vol.103 , Issue.3 , pp. 416-422
    • Franceschi, S.1    Lise, M.2    Clifford, G.M.3
  • 9
    • 20044383386 scopus 로고    scopus 로고
    • The changing incidence of AIDS events in patients receiving highly active antiretroviral therapy
    • Antiretroviral Therapy Cohort Collaboration
    • d'Arminio Monforte A, Sabin CA, Phillips A, et al; Antiretroviral Therapy Cohort Collaboration. The changing incidence of AIDS events in patients receiving highly active antiretroviral therapy. Arch Intern Med. 2005;165(4):416-423.
    • (2005) Arch Intern Med , vol.165 , Issue.4 , pp. 416-423
    • D'Arminio Monforte, A.1    Sabin, C.A.2    Phillips, A.3
  • 10
    • 0033519782 scopus 로고    scopus 로고
    • Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretroviral therapy: Prospective cohort study
    • Swiss HIV Cohort Study
    • Ledergerber B, Telenti A, Egger M. Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretroviral therapy: prospective cohort study. Swiss HIV Cohort Study. BMJ. 1999;319(7201):23-24.
    • (1999) BMJ , vol.319 , Issue.7201 , pp. 23-24
    • Ledergerber, B.1    Telenti, A.2    Egger, M.3
  • 11
    • 0034669127 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virusinfected adults
    • International Collaboration on HIV and Cancer. Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virusinfected adults. J Natl Cancer Inst. 2000;92(22): 1823-1830.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.22 , pp. 1823-1830
  • 12
    • 77957825211 scopus 로고    scopus 로고
    • Cancer as a cause of death among people with AIDS in the United States
    • Simard EP, Engels EA. Cancer as a cause of death among people with AIDS in the United States. Clin Infect Dis. 2010;51(8):957-962.
    • (2010) Clin Infect Dis , vol.51 , Issue.8 , pp. 957-962
    • Simard, E.P.1    Engels, E.A.2
  • 13
    • 0031633391 scopus 로고    scopus 로고
    • Genetic basis of acquired immunodeficiency syndromerelated lymphomagenesis
    • Gaidano G, Carbone A, Dalla-Favera R. Genetic basis of acquired immunodeficiency syndromerelated lymphomagenesis. J Natl Cancer Inst Monogr. 1998;(23):95-100.
    • (1998) J Natl Cancer Inst Monogr , vol.23 , pp. 95-100
    • Gaidano, G.1    Carbone, A.2    Dalla-Favera, R.3
  • 14
    • 84983730878 scopus 로고    scopus 로고
    • Lymphadenopathy and the lymphoid neoplasms associated with HIV infection and other causes of immunosuppression
    • Orazzi AWL, Foucar K, Knowles DM, eds Baltimore: Wolters Kuwer/ Williams and Wilkins
    • Said J, Cesarman E, Knowles D. Lymphadenopathy and the lymphoid neoplasms associated with HIV infection and other causes of immunosuppression. In: Orazzi AWL, Foucar K, Knowles DM, eds. Knowles' Neoplastic Hematopathology. Baltimore: Wolters Kuwer/ Williams and Wilkins; 2014:584-658.
    • (2014) Knowles' Neoplastic Hematopathology , pp. 584-658
    • Said, J.1    Cesarman, E.2    Knowles, D.3
  • 15
    • 0037245070 scopus 로고    scopus 로고
    • Emerging pathways in the development of AIDS-related lymphomas
    • Carbone A. Emerging pathways in the development of AIDS-related lymphomas. Lancet Oncol. 2003;4(1):22-29.
    • (2003) Lancet Oncol , vol.4 , Issue.1 , pp. 22-29
    • Carbone, A.1
  • 16
    • 79955465167 scopus 로고    scopus 로고
    • Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients
    • Cesarman E. Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients. Cancer Lett. 2011;305(2):163-174.
    • (2011) Cancer Lett. , vol.305 , Issue.2 , pp. 163-174
    • Cesarman, E.1
  • 17
    • 44149123399 scopus 로고    scopus 로고
    • Adult and Adolescent Spectrum of Disease Project and HIV Outpatient Study Investigators. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003
    • Patel P, Hanson DL, Sullivan PS, et al; Adult and Adolescent Spectrum of Disease Project and HIV Outpatient Study Investigators. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003. Ann Intern Med. 2008;148(10): 728-736.
    • (2008) Ann Intern Med , vol.148 , Issue.10 , pp. 728-736
    • Patel, P.1    Hanson, D.L.2    Sullivan, P.S.3
  • 19
    • 0037443485 scopus 로고    scopus 로고
    • A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival
    • Hans CP, Weisenburger DD, Vose JM, et al. A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival. Blood. 2003;101(6):2363-2367.
    • (2003) Blood , vol.101 , Issue.6 , pp. 2363-2367
    • Hans, C.P.1    Weisenburger, D.D.2    Vose, J.M.3
  • 20
    • 77649088435 scopus 로고    scopus 로고
    • Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034
    • Chadburn A, Chiu A, Lee JY, et al. Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034. J Clin Oncol. 2009;27(30):5039-5048.
    • (2009) J Clin Oncol , vol.27 , Issue.30 , pp. 5039-5048
    • Chadburn, A.1    Chiu, A.2    Lee, J.Y.3
  • 21
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9(4): 357-359.
    • (2012) Nat Methods , vol.9 , Issue.4 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 22
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009;25(14):1754-1760.
    • (2009) Bioinformatics , vol.25 , Issue.14 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 23
    • 84865137988 scopus 로고    scopus 로고
    • An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions
    • Arvey A, Tempera I, Tsai K, et al. An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host Microbe. 2012;12(2):233-245.
    • (2012) Cell Host Microbe , vol.12 , Issue.2 , pp. 233-245
    • Arvey, A.1    Tempera, I.2    Tsai, K.3
  • 24
    • 79955778143 scopus 로고    scopus 로고
    • PathSeq: Software to identify or discover microbes by deep sequencing of human tissue
    • Kostic AD, Ojesina AI, Pedamallu CS, et al. PathSeq: software to identify or discover microbes by deep sequencing of human tissue. Nat Biotechnol. 2011;29(5):393-396.
    • (2011) Nat Biotechnol , vol.29 , Issue.5 , pp. 393-396
    • Kostic, A.D.1    Ojesina, A.I.2    Pedamallu, C.S.3
  • 25
    • 79960264362 scopus 로고    scopus 로고
    • Fulllength transcriptome assembly from RNA-Seq data without a reference genome
    • Grabherr MG, Haas BJ, Yassour M, et al. Fulllength transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol. 2011;29(7):644-652.
    • (2011) Nat Biotechnol , vol.29 , Issue.7 , pp. 644-652
    • Grabherr, M.G.1    Haas, B.J.2    Yassour, M.3
  • 26
    • 84863022950 scopus 로고    scopus 로고
    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
    • Kostic AD, Gevers D, Pedamallu CS, et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012;22(2):292-298.
    • (2012) Genome Res , vol.22 , Issue.2 , pp. 292-298
    • Kostic, A.D.1    Gevers, D.2    Pedamallu, C.S.3
  • 27
    • 84912076762 scopus 로고    scopus 로고
    • Microbial contamination in next generation sequencing: Implications for sequence-based analysis of clinical samples
    • Strong MJ, Xu G, Morici L, et al. Microbial contamination in next generation sequencing: implications for sequence-based analysis of clinical samples. PLoS Pathog. 2014;10(11): e1004437.
    • (2014) PLoS Pathog , vol.10 , Issue.11 , pp. e1004437
    • Strong, M.J.1    Xu, G.2    Morici, L.3
  • 28
    • 84910643215 scopus 로고    scopus 로고
    • Unexpected patterns of Epstein-Barr virus transcription revealed by a high throughput PCR array for absolute quantification of viral mRNA
    • Tierney RJ, Shannon-Lowe CD, Fitzsimmons L, Bell AI, Rowe M. Unexpected patterns of Epstein-Barr virus transcription revealed by a high throughput PCR array for absolute quantification of viral mRNA. Virology. 2015;474: 117-130.
    • (2015) Virology , vol.474 , pp. 117-130
    • Tierney, R.J.1    Shannon-Lowe, C.D.2    Fitzsimmons, L.3    Bell, A.I.4    Rowe, M.5
  • 29
    • 0024469159 scopus 로고
    • Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease
    • Young L, Alfieri C, Hennessy K, et al. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med. 1989; 321(16):1080-1085.
    • (1989) N Engl J Med , vol.321 , Issue.16 , pp. 1080-1085
    • Young, L.1    Alfieri, C.2    Hennessy, K.3
  • 30
    • 0031856312 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus latent genes and adhesion molecules in AIDS-related non-Hodgkin's lymphomas: Correlation with histology and CD4-cell number
    • Kersten MJ, Van Gorp J, Pals ST, Boon F, Van Oers MH. Expression of Epstein-Barr virus latent genes and adhesion molecules in AIDS-related non-Hodgkin's lymphomas: correlation with histology and CD4-cell number. Leuk Lymphoma. 1998;30(5-6):515-524.
    • (1998) Leuk Lymphoma , vol.30 , Issue.5-6 , pp. 515-524
    • Kersten, M.J.1    Van Gorp, J.2    Pals, S.T.3    Boon, F.4    Van Oers, M.H.5
  • 31
    • 84867051939 scopus 로고    scopus 로고
    • Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
    • Schmitz R, Young RM, Ceribelli M, et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012;490(7418):116-120.
    • (2012) Nature , vol.490 , Issue.7418 , pp. 116-120
    • Schmitz, R.1    Young, R.M.2    Ceribelli, M.3
  • 32
    • 20244388788 scopus 로고    scopus 로고
    • Promiscuous expression of Epstein-Barr virus genes in Burkitt's lymphoma from the central African country Malawi
    • Xue SA, Labrecque LG, Lu QL, et al. Promiscuous expression of Epstein-Barr virus genes in Burkitt's lymphoma from the central African country Malawi. Int J Cancer. 2002;99(5): 635-643.
    • (2002) Int J Cancer , vol.99 , Issue.5 , pp. 635-643
    • Xue, S.A.1    Labrecque, L.G.2    Lu, Q.L.3
  • 33
    • 33749044616 scopus 로고    scopus 로고
    • Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative realtime PCR assays
    • Bell AI, Groves K, Kelly GL, et al. Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative realtime PCR assays. J Gen Virol. 2006;87(Pt 10): 2885-2890.
    • (2006) J Gen Virol , vol.87 , pp. 2885-2890
    • Bell, A.I.1    Groves, K.2    Kelly, G.L.3
  • 34
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell C, Williams BA, Pertea G, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 2010;28(5):511-515.
    • (2010) Nat Biotechnol , vol.28 , Issue.5 , pp. 511-515
    • Trapnell, C.1    Williams, B.A.2    Pertea, G.3
  • 35
    • 45549083730 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and cochaperones
    • Young P, Anderton E, Paschos K, White R, Allday MJ. Epstein-Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and cochaperones. JGen Virol.2008;89(Pt 4): 866-877.
    • (2008) JGen Virol , vol.89 , pp. 866-877
    • Young, P.1    Anderton, E.2    Paschos, K.3    White, R.4    Allday, M.J.5
  • 36
    • 78650376729 scopus 로고    scopus 로고
    • Soluble CD30: A serum marker for Epstein-Barr virus-associated lymphoproliferative diseases
    • Haque T, Chaggar T, Schafers J, Atkinson C, McAulay KA, Crawford DH. Soluble CD30: a serum marker for Epstein-Barr virus-associated lymphoproliferative diseases. J Med Virol. 2011; 83(2):311-316.
    • (2011) J Med Virol , vol.83 , Issue.2 , pp. 311-316
    • Haque, T.1    Chaggar, T.2    Schafers, J.3    Atkinson, C.4    McAulay, K.A.5    Crawford, D.H.6
  • 38
    • 78649489748 scopus 로고    scopus 로고
    • Why do viruses cause cancer? Highlights of the first century of human tumour virology
    • Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer. 2010;10(12): 878-889.
    • (2010) Nat Rev Cancer , vol.10 , Issue.12 , pp. 878-889
    • Moore, P.S.1    Chang, Y.2
  • 39
    • 0033895812 scopus 로고    scopus 로고
    • Gammaherpesviruses and "Hit-and-Run" oncogenesis
    • Ambinder RF. Gammaherpesviruses and "Hit-and-Run" oncogenesis. Am J Pathol. 2000;156(1):1-3.
    • (2000) Am J Pathol , vol.156 , Issue.1 , pp. 1-3
    • Ambinder, R.F.1
  • 40
    • 28844444995 scopus 로고    scopus 로고
    • Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas
    • Bechtel D, Kurth J, Unkel C, Küppers R. Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas. Blood. 2005; 106(13):4345-4350.
    • (2005) Blood , vol.106 , Issue.13 , pp. 4345-4350
    • Bechtel, D.1    Kurth, J.2    Unkel, C.3    Küppers, R.4
  • 41
    • 28844502383 scopus 로고    scopus 로고
    • Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus
    • Mancao C, Altmann M, Jungnickel B, Hammerschmidt W. Rescue of "crippled" germinal center B cells from apoptosis by Epstein-Barr virus. Blood. 2005;106(13): 4339-4344.
    • (2005) Blood , vol.106 , Issue.13 , pp. 4339-4344
    • Mancao, C.1    Altmann, M.2    Jungnickel, B.3    Hammerschmidt, W.4
  • 42
    • 64049099870 scopus 로고    scopus 로고
    • The intersection of Epstein-Barr virus with the germinal center
    • Roughan JE, Thorley-Lawson DA. The intersection of Epstein-Barr virus with the germinal center. J Virol. 2009;83(8): 3968-3976.
    • (2009) J Virol , vol.83 , Issue.8 , pp. 3968-3976
    • Roughan, J.E.1    Thorley-Lawson, D.A.2
  • 43
    • 51649087471 scopus 로고    scopus 로고
    • Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma
    • Dittmer DP, Hilscher CJ, Gulley ML, Yang EV, Chen M, Glaser R. Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma. Int J Cancer. 2008;123(9):2105-2112.
    • (2008) Int J Cancer , vol.123 , Issue.9 , pp. 2105-2112
    • Dittmer, D.P.1    Hilscher, C.J.2    Gulley, M.L.3    Yang, E.V.4    Chen, M.5    Glaser, R.6
  • 44
    • 0030020804 scopus 로고    scopus 로고
    • Epstein-Barr Virus DNA recombination and loss in sporadic Burkitt's lymphoma
    • Razzouk BI, Srinivas S, Sample CE, Singh V, Sixbey JW. Epstein-Barr Virus DNA recombination and loss in sporadic Burkitt's lymphoma. J Infect Dis. 1996;173(3):529-535.
    • (1996) J Infect Dis , vol.173 , Issue.3 , pp. 529-535
    • Razzouk, B.I.1    Srinivas, S.2    Sample, C.E.3    Singh, V.4    Sixbey, J.W.5
  • 45
    • 0031750736 scopus 로고    scopus 로고
    • Spontaneous loss of viral episomes accompanying Epstein-Barr virus reactivation in a Burkitt's lymphoma cell line
    • Srinivas SK, Sample JT, Sixbey JW. Spontaneous loss of viral episomes accompanying Epstein-Barr virus reactivation in a Burkitt's lymphoma cell line. J Infect Dis. 1998; 177(6):1705-1709.
    • (1998) J Infect Dis , vol.177 , Issue.6 , pp. 1705-1709
    • Srinivas, S.K.1    Sample, J.T.2    Sixbey, J.W.3
  • 46
    • 84879295275 scopus 로고    scopus 로고
    • HIV-associated chronic immune activation
    • Paiardini M, Müller-Trutwin M. HIV-associated chronic immune activation. Immunol Rev. 2013; 254(1):78-101.
    • (2013) Immunol Rev , vol.254 , Issue.1 , pp. 78-101
    • Paiardini, M.1    Müller-Trutwin, M.2
  • 47
    • 84859415408 scopus 로고    scopus 로고
    • Spatial alterations between CD4(1) T follicular helper, B, and CD8(1) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape
    • Hong JJ, Amancha PK, Rogers K, Ansari AA, Villinger F. Spatial alterations between CD4(1) T follicular helper, B, and CD8(1) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol. 2012;188(7): 3247-3256.
    • (2012) J Immunol , vol.188 , Issue.7 , pp. 3247-3256
    • Hong, J.J.1    Amancha, P.K.2    Rogers, K.3    Ansari, A.A.4    Villinger, F.5


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