Changes in stratum corneum thickness, water gradients and hydration by moisturizers

Treatment of Dry Skin Syndrome: The Art and Science of Moisturizers

Volumn 9783642276064, Issue , 2012, Pages 545-560

  Crowther, Jonathan M ^a   Matts, Paul J ^a   Kaczvinsky, Joseph R ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84945441789     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-27606-4_38     Document Type: Chapter

References (84)

1. Blank IH (1952) Factors which influence the water content of the stratum corneum. J Invest Dermatol 18:433-440
2. Grubauer G, Elias PM, Feingold KR (1989) Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res 30:323-333
3. Loden M (1995) Biophysical properties of dry atopic and normal skin with special reference to skin care products. Acta Derm Venereol Suppl (Stockholm) 192:1-48
4. Agache P (2004) Stratum corneum histopathology. In: Agache P, Humbert P (eds) Measuring the skin. Springer, Berlin
5. Warner RR, Myers MC, Taylor DA (1988) Electron probe analysis of human skin: determination of the water concentration profile. J Invest Dermatol 90:218-244
6. Warner RR, Lilly NA (1994) Correlation of water content with ultrastructure in the stratum corneum. In: Elsner P, Berardesca E, Maibach HI (eds) Bioengineering of the skin: water and the stratum corneum. CRC Press Inc, Boca Raton
7. Richter T, Peuckert C, Sattler M et al (2004) Dead but highly dynamic - the stratum corneum is divided into three hydration zones. Skin Pharmacol Physiol 17:246-257
8. Bouwstra JA, De Graff A, Gooris GS et al (2003) Water distribution and related morphology in human stratum corneum at different hydration levels. J Invest Dermatol 120(5):750-758
9. Rawlings AV, Scott IR, Harding CR, Bowser P (1994) Stratum corneum moisturization at the molecular level. J Invest Dermatol 103:731-734
10. Brancaleon L, Bamberg MP, Sakamaki T, Kollias N (2001) Attenuated total reflection-Fourier transform infrared spectroscopy as a possible method to investigate biophysical parameters of stratum corneum in vivo. J Invest Dermatol 116:380-386
11. Arimoto H, Egawa M, Yamada Y (2005) Depth profile of diffuse reflectance near-infrared spectroscopy for measurement of water content in skin. Skin Res Technol 11:27-35
12. Robinson M, Visscher M, Laruffa A, Wickett R (2010) Natural moisturizing factors (NMF) in the stratum corneum (SC). II. Regeneration of NMF over time after soaking. J Cosmet Sci 61(1):23-29
13. Caspers PJ, Lucassen GW, Carter EA et al (2001) In vivo confocal Raman microspectrometer of the skin. Noninvasive determination of molecular concentration profiles. J Invest Dermatol 116:434-442
14. Wertz PW (2004) Stratum corneum lipids and water. Exogenous Dermatol 3:53-56
15. Kalia YN, Alberti I, Sekkat N et al (2000) Normalization of stratum corneum barrier function and transepidermal water loss in vivo. Pharma Res 17(9):1148-1150
16. Pirot F, Berardesca E, Kalia YN et al (1998) Stratum corneum thickness and apparent water diffusivity: facile and noninvasive quantification in vivo. Pharma Res 15(3):492-494
17. Dikstein S, Zlotogorski A (1994) Measurement of skin pH. Acta Dermatol Venereol (Stockholm) 185:18-20
18. Ohman H, Vahlquist A (1994) In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis. Acta Dermatol Venereol (Stockholm) 74:375-379
19. Krien PM, Kermici M (2000) Evidence for the existence of self regulated enzymatic process within the human stratum corneum: an unexpected role for urocanic acid. J Invest Dermatol 115:414-420
20. Aberg C, Wennerstrom H, Sparr E (2008) Transport processes in responding lipid membranes: a possible mechanism for pH gradient in the stratum corneum. Langmuir 24:8061-8070
21. Lieckfeldt R, Villalain J, Gomez-Fernandez JC, Lee G (1995) Apparent pKa of the fatty acids within ordered mixtures of model human stratum corneum lipids. Pharmacol Res 12:1614-1617
22. Patterson MJ, Galloway SD, Nimmo NA (2000) Variations in regional sweat composition in normal human males. Exp Physiol 85:869-875
23. Behne M, Oda Y, Murata S et al (2000) Functional role of the sodium-hydrogen antiporter, NHE1, in the epidermis: pharmacologic and NHE1 null-allele mouse studies. J Invest Dermatol 114:797
24. Visscher MO, Chatterjee R, Munson KS et al (2000) Changes in diapered and nondiapered infant skin over the first month of life. Pediatr Dermatol 17:45-51
25. Hanson KM, Barry NP, Gratton E, Clegg RM (2000) Fluorescence lifetime imaging of pH in the stratum corneum. Biophys J Annu Meet Abstr: B588
26. Hanson KM, Behne MJ, Barry NP et al (2002) Twophoton fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophys J 83:1682-1690
27. Menon GK, Grayson S, Elias PM (1985) Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508-512
28. Mauro T, Bench G, Sidderas-Haddad E et al (1998) Acute barrier perturbation abolishes the Ca 2+ and K + gradients in murine epidermis: quantitative measurement using PIXE. J Invest Dermatol 111:1198-1201
29. Elias PM, Ahn SK, Brown BE et al (2002) Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms. J Invest Dermatol 119:1269-1274
30. Prasch T, Knübel G, Schmidt-Fonk K et al (2000) Infrared spectroscopy of the skin: influencing the stratum corneum with cosmetic products. Int J Cosmet Sci 22:371-383
31. Hathout RM, Mansour S, Mortada ND et al (2010) Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Mol Pharm 7(4):1266-1273
32. Notingher I, Imhof RE (2004) Mid-infrared in vivo depth-profiling of topical chemicals on skin. Skin Res Technol 10:113-121
33. Stamatas GN, De Sterke J, Hauser M et al (2008) Lipid uptake and skin occlusion following topical application of oils on adult and infant skin. J Dermatol Sci 50:135-142
34. Chrit L, Bastien P, Sockalingum GD et al (2006) An in vivo randomized study of human skin moisturization by a new confocal Raman fiber-optic microprobe: assessment of a glycerol-based hydration cream. Skin Pharmacol Physiol 19(4):207-215
35. Chrit L, Bastien P, Biatry B et al (2006) In vitro and in vivo confocal Raman study of human skin hydration: assessment of anew moisturizing agent, pMPC. Biopolymers 85:359-369
36. Förster M, Bolzinger MA, Ach D et al (2011) Ingredients tracking of cosmetic formulations in the skin: a confocal Raman microscopy investigation. Pharm Res 28(4):858-872
37. Williams AC, Barry BW, Edwards HGM, Farwell DW (1993) A critical comparison of some Raman spectroscopic techniques for studies of human stratum corneum. Pharm Res 10:1642-1647
38. Williams AC, Edwards HGM, Barry BW (1992) Fourier transform Raman spectroscopy. A novel application for examining human stratum corneum. Int J Pharm 81:R11-R14
39. Lucassen GW, Caspers PJ, Puppels GJ (1998) In vivo infrared and Raman spectroscopy of human stratum corneum. Proc SPIE 3257:52-61
40. Shim MG, Wilson BC (1997) Development of an in vivo Raman spectroscopic system for diagnostic applications. J Raman Spectrosc 28:131-142
41. Caspers PJ, Lucassen GW, Wolthuis R et al (1998) In vitro and in vivo Raman spectroscopy of human skin. Biospectroscopy 4:S31-S39
42. Caspers PJ, Lucassen GW, Bruining HJ, Puppels GJ (2000) Automated depth-scanning confocal Raman microspectrometer for rapid in vivo determination of water concentration profiles in human skin. J Raman Spectrosc 31:813-818
43. Caspers PJ, Lucassen GW, Puppels GJ (2003) Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. Biophys J 85:572-580
44. Chrit L, Hadjur C, Morel S et al (2005) In vivo chemical investigation of human skin using a confocal Raman fiber optic microprobe. J Biomed Opt 10(4):44007
45. Egawa M, Hirao T, Takahashi M (2007) In vivo estimation of stratum corneum thickness from water concentration profiles obtained with Raman spectroscopy. Acta Derm Venereol 87(1):4-8
46. Egawa M, Tagami H (2008) Comparison of the depth profiles of water and water binding substances in the stratum corneum determined by Raman spectroscopy between the cheek and volar forearm: effects of age, seasonal changes and artificial forced hydration. Br J Dermatol 158:251-260
47. Chrit L, Bastien P, Biatry B et al (2007) In vitro and in vivo confocal Raman study of human skin hydration: assessment of a new moisturizing agent, pMPC. Biopolymers 85(4):359-369
48. Crowther JM, Sieg A, Blenkiron P et al (2008) Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo. Br J Dermatol 159:567-577
49. Naito S, Min YK, Osanai O et al (2008) In vivo measurement of human dermis by 1064 nm-excited fiber Raman spectroscopy. Skin Res Technol 14:18-25
50. Bielfeldt S, Schoder V, Ely U et al (2009) Assessment of human stratum corneum thickness and its barrier properties by in-vivo confocal Raman spectroscopy. IFSCC Mag 12:9-15
51. Baldwin K, Batchelder D (2001) Confocal Raman microspectroscopy through a planar interface. Appl Spectrosc 55:517-524
52. Tfayli A, Piot O, Manfait M (2008) Confocal Raman microspectroscopy on excised human skin: uncertainties in depth profiling and mathematical correction applied to dermatological drug permeation. J Biophotonics 1:140-153
53. Welzel J (2001) Optical coherence tomography in dermatology: a review. Skin Res Technol 7:1-9
54. Ya-Xian Z, Suetake T, Tagami H (1999) Number of cell layers of the stratum corneum in normal skin - relationship to the anatomical locations on the body, age, sex and physical parameters. Arch Dermatol Res 291:555-559
55. Gambichler T, Boms S, Stacker M et al (2006) Epidermal thickness assessed by optical coherence tomography and routine histology: preliminary results of method comparison. J Eur Acad Dermatol Venereol 20(7):791-795
56. Lademann J, Otberg N, Richter H et al (2007) Application of optical non-invasive methods in skin physiology: a comparison of laser scanning microscopy and optical coherent tomography with histological analysis. Skin Res Technol 13(2):119-132
57. Norlen L (2006) Stratum corneum keratin structure, function and formation - a comprehensive review. Int J Cosmet Sci 28(6):397-425
58. Wu J, Polefka TG (2008) Confocal Raman microspectroscopy of stratum corneum: a pre-clinical validation study. Int J Cosmet Sci 30:47-56
59. Matts PJ, Gray J, Rawlings AV (2005) The 'dry skin cycle' - a new model of dry skin and mechanisms for intervention (International congress and symposium series), vol 256. The Royal Society of Medicine Press Ltd, London, pp 1-38
60. Loden M (2005) The clinical benefit of moisturizers. JEADV 19:672-688
61. Breternitz M, Kowatski D, Langenauer M et al (2008) Placebo controlled, double blind, randomized prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation. Skin Pharmacol Physiol 21:39-45
62. Summers RS, Summers B, Chandar P et al (1996) The effect of lipids with and without humectants on skin xerosis. J Soc Cosmet Chem 47:27-39
63. Rawlings AV, Watkinson A, Hope J et al (1995) The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch Dermatol Res 287:457-464
64. Held E, Sveinsdottir S, Agner T (1999) Effect of long term use of moisturizer on skin hydration, barrier function and susceptibility to irritants. Acta Derm Venereol 79:49-51
65. Zachariae C, Held E, Johansen JD et al (2003) Effect of a moisturizer on skin susceptibility to NiCl2. Acta Derm Venereol 83:93-97
66. Berardesca E, Distante F, Vignoli GP et al (1997) Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol 137:934-938
67. Buraczewska I, Berne B, Lindberg M et al (2007) Changes in skin barrier function following long-term treatment with moisturizers, a randomized controlled trial. Br J Dermatol 156:492-498
68. Barany E, Lindberg M, Loden M (2000) Unexpected skin barrier influence from non-ionic emulsifiers. Int J Pharm 195:189-195
69. Fluhr JW, Gloor M, Lehmann L et al (1999) Glycerol accelerates recovery of barrier function in vivo. Acta Derm Venereol 79:418-421
70. Loden M, Andersson AC, Andersson C et al (2001) Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis. Skin Res Technol 7:209-213
71. Rawlings AV, Conti A, Verdejo P et al (1996) The effect of lactic acid isomers on epidermal lipid biosynthesis and stratum corneum barrier function. Arch Dermatol Res 288:383-390
72. Norlen L, Emilson A, Forslind B (1997) Stratum corneum swelling. Biophysical and computer assisted quantitative assessments. Arch Dermatol Res 289:506-513
73. Richter T, Muller JH, Schwarz UD et al (2001) Investigation of the swelling of human skin cells in liquid media by tapping mode scanning force microscopy. Appl Phys A A72:S125-S128
74. Bouwstra JA, De Graaff A, Gooris GS et al (2003) Water distribution and related morphology in human stratum corneum at different hydration levels. J Invest Dermatol 120:750-758
75. Caussin J, Groenink HWW, De Graaff AM et al (2007) Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy. Exp Dermatol 16:891-898
76. Orth DS, Appa Y, Contard P et al (1995) Effect of high glycerin moisturizers on the ultrastructure of the stratum corneum. Poster at the 53rd annual meeting of the American Academy of Dermatology, New Orleans, Feb. 1995
77. Orth DS, Appa Y (2000) Glycerine: a natural ingredient for moisturizing skin. In: Loden M, Maibach HI (eds) Dry skin and moisturizers: chemistry and function. CRC Press, Boca Raton
78. Fluhr JW, Bornkessel A, Berardesca E (2006) Glycerol-just a moisturizer? Biological & biophysical effects. In: Loden M, Maibach HI (eds) Dry skin and moisturizers, 2nd edn. CRC Press, Boca Raton
79. Jacobson EL, Kim H, Kim M et al (2007) A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin. Exp Dermatol 16(6):490-499
80. Loden M, Wessman C (2001) The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties. Int J Cosmet Sci 23:115-119
81. Fluhr JW, Mao-Qiang M, Brown BE et al (2003) Glycerol regulates stratum corneum hydration in sebaceous gland deficient (Asebia) mice. J Invest Dermatol 120:728-737
82. Choi EH, Man MQ, Wang F et al (2005) Is endogenous glycerol a determinant of stratum corneum hydration in humans? J Invest Dermatol 125:288-293
83. Crowther JM, Matts PJ, publication in preparation
84. Kaczvinsky JR, publication in preparation