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Volumn 21, Issue 2, 2015, Pages 65-71

Effects of aloe vera supplements on blood glucose level and lipid profile markers in type 2 diabetic patients - A randomized clinical trial

Author keywords

Aloe Vera Supplement; Blood Glucose; Diabetes Mellitus; Herbal Medici; Lipid Profile

Indexed keywords

ALOE VERA EXTRACT; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; LIPID; LOW DENSITY LIPOPROTEIN; PLACEBO; TRIACYLGLYCEROL;

EID: 84945348397     PISSN: 1735-403X     EISSN: 2383-2886     Source Type: Journal    
DOI: 10.15171/PS.2015.19     Document Type: Article
Times cited : (18)

References (40)
  • 1
    • 0003146514 scopus 로고    scopus 로고
    • Diabetes Mellitus
    • Longo DL, Fauci AS, Kasper DL, Hauser SL, Jamson JL, Loscalzo J, McGrow-Hill, Columbus
    • Power AC. Diabetes Mellitus. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jamson JL, Loscalzo J : Harrison's Principles Of Internal Medicine. McGrow-Hill, Columbus, 2012:2968-2975.
    • (2012) Harrison's Principles of Internal Medicine , pp. 2968-2975
    • Power, A.C.1
  • 2
    • 84999423139 scopus 로고    scopus 로고
    • Prevalence of Diabetes in Zambuk General Hospital
    • Lynn Maori, Dorcas Ezekiel and Joy Bilal. Prevalence of Diabetes in Zambuk General Hospital. Rep Opinion 2012;4:54-57.
    • (2012) Rep Opinion , vol.4 , pp. 54-57
    • Maori, L.1    Ezekiel, D.2    Bilal, J.3
  • 5
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care 2004;27:1047-53. doi:10.2337/diacare.27.10.2569-a
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 6
    • 84862023845 scopus 로고    scopus 로고
    • Lipid Profiles and Serum Visfatin Concentrations in Patients with Type II Diabetes in Comparison with Healthy Controls
    • Hajianfar H, Bahonar A, Entezari MH, Askari G, Yazdani M. Lipid Profiles and Serum Visfatin Concentrations in Patients with Type II Diabetes in Comparison with Healthy Controls. Int J Prev Med 2012;3:326-331.
    • (2012) Int J Prev Med , vol.3 , pp. 326-331
    • Hajianfar, H.1    Bahonar, A.2    Entezari, M.H.3    Askari, G.4    Yazdani, M.5
  • 7
    • 85015052133 scopus 로고    scopus 로고
    • Profile of type 2 diabetes mellitus without overt complications of diabetes mellitus at a tertiary care center
    • Singla R, Ambekar S, Nand K, Singh MB, Gupta N, Jyotsna VP. Profile of type 2 diabetes mellitus without overt complications of diabetes mellitus at a tertiary care center. Indian J Endocrinol Metab 2012;16:S468-470. doi: 10.4103/2230-8210.104134.
    • (2012) Indian J Endocrinol Metab , vol.16 , pp. S468-470
    • Singla, R.1    Ambekar, S.2    Nand, K.3    Singh, M.B.4    Gupta, N.5    Jyotsna, V.P.6
  • 8
    • 0033377677 scopus 로고    scopus 로고
    • The effect of fenofibrate on insulin sensitivity and plasma lipid profile in non-diabetic males with low high density lipoprotein/dyslipidaemic syndrome
    • Yong QW, Thavintharan S, Cheng A, Chew LS. The effect of fenofibrate on insulin sensitivity and plasma lipid profile in non-diabetic males with low high density lipoprotein/dyslipidaemic syndrome. Ann Acad Med Singapore 1999;28:778-782.
    • (1999) Ann Acad Med Singapore , vol.28 , pp. 778-782
    • Yong, Q.W.1    Thavintharan, S.2    Cheng, A.3    Chew, L.S.4
  • 9
    • 0034527598 scopus 로고    scopus 로고
    • Effect of insulin and sulfonylurea therapy, at the same level of blood glucose control, on low density lipoprotein subfractions in type 2 diabetic patients
    • Rivellese AA, Patti L, Romano G, Innelli F, Di Marino L, Annuzzi G, et al. Effect of insulin and sulfonylurea therapy, at the same level of blood glucose control, on low density lipoprotein subfractions in type 2 diabetic patients. J Clin Endocrinol Metab 2000;85:4188-4192. doi: 10.1210/jc.85.11.4188
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4188-4192
    • Rivellese, A.A.1    Patti, L.2    Romano, G.3    Innelli, F.4    Di Marino, L.5    Annuzzi, G.6
  • 10
    • 84887623941 scopus 로고    scopus 로고
    • Effect of high doses of Vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients
    • Breslavsky A, Frand J, Matas Z, Boaz M, Barnea Z, Shargorodsky M. Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients. Clin Nutr 2013;32:970-975. doi: 10.1016/j.clnu.2013.01.020
    • (2013) Clin Nutr , vol.32 , pp. 970-975
    • Breslavsky, A.1    Frand, J.2    Matas, Z.3    Boaz, M.4    Barnea, Z.5    Shargorodsky, M.6
  • 11
    • 84874332463 scopus 로고    scopus 로고
    • Effect of the magnetized water supplementation on blood glucose, lymphocyte DNA damage, antioxidant status, and lipid profiles in STZ-induced rats
    • Lee HJ, Kang MH. Effect of the magnetized water supplementation on blood glucose, lymphocyte DNA damage, antioxidant status, and lipid profiles in STZ-induced rats. Nutr Res Pract 2013;7:34-42. doi: 10.4162/nrp.2013.7.1.34
    • (2013) Nutr Res Pract , vol.7 , pp. 34-42
    • Lee, H.J.1    Kang, M.H.2
  • 13
    • 80054944058 scopus 로고    scopus 로고
    • Effects of Mesembrrybryanthemum forsskalei Hochst seeds in lowering glucose/lipid profile in streptozotocin-induced diabetic rats
    • Al Faris NA, Al Othman ZA, Ahmad D. Effects of Mesembrrybryanthemum forsskalei Hochst seeds in lowering glucose/lipid profile in streptozotocin-induced diabetic rats. J Food Sci Technol 2011; 48: 616-621.
    • (2011) J Food Sci Technol , vol.48 , pp. 616-621
    • Al Faris, N.A.1    Al Othman, Z.A.2    Ahmad, D.3
  • 14
    • 0042668497 scopus 로고    scopus 로고
    • Systematic review of herbs and dietary supplements for glycemic control in diabetes
    • Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 2003;26:1277-1294. doi: 10.2337/diacare.26.4.1277.
    • (2003) Diabetes Care , vol.26 , pp. 1277-1294
    • Yeh, G.Y.1    Eisenberg, D.M.2    Kaptchuk, T.J.3    Phillips, R.S.4
  • 15
    • 79955791650 scopus 로고    scopus 로고
    • Nutritional supplements and their effect on glucose control
    • Lee T, Dugoua JJ. Nutritional supplements and their effect on glucose control. Curr Diabetes Rep 2011;11:142-148. doi: 10.1007/978-1-4614-5441-0-27
    • (2011) Curr Diabetes Rep , vol.11 , pp. 142-148
    • Lee, T.1    Dugoua, J.J.2
  • 16
    • 84974798146 scopus 로고    scopus 로고
    • Evaluation of the Nutritional and Metabolic Effects of Aloe vera
    • Benzie IFF, Wachtel-Galor S, editors., 2nd ed. Boca Raton FL
    • Foster M, Hunter D, Samman S. Evaluation of the Nutritional and Metabolic Effects of Aloe vera. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton FL;2011.
    • (2011) Herbal Medicine: Biomolecular and Clinical Aspects
    • Foster, M.1    Hunter, D.2    Samman, S.3
  • 18
    • 34250848241 scopus 로고    scopus 로고
    • Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus
    • Lans C.A. Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J Ethnobiol Ethnomed 2006;2:45-55.
    • (2006) J Ethnobiol Ethnomed , vol.2 , pp. 45-55
    • Lans, C.A.1
  • 21
    • 0035067049 scopus 로고    scopus 로고
    • Effect of Aloe vera leaves on blood glucose level in type i and type II diabetic rat models
    • Okyar A, Can A, Akev N, Baktir G, Sutlupinar N. Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytother Res 2001;15:157-161. doi: 10.1002/ptr.719
    • (2001) Phytother Res , vol.15 , pp. 157-161
    • Okyar, A.1    Can, A.2    Akev, N.3    Baktir, G.4    Sutlupinar, N.5
  • 22
    • 84890254562 scopus 로고    scopus 로고
    • Dietary Aloe QDM Complex Reduces Obesity-Induced Insulin Resistance and Adipogenesis in Obese Mice Fed a High-Fat Diet
    • Shin S, Kim S, Oh HE, Kong H, Shin E, Do SG, et al. Dietary Aloe QDM Complex Reduces Obesity-Induced Insulin Resistance and Adipogenesis in Obese Mice Fed a High-Fat Diet. Immune Netw 2012;12:96-103. doi:10.4110/in.2012.12.3.96
    • (2012) Immune Netw , vol.12 , pp. 96-103
    • Shin, S.1    Kim, S.2    Oh, H.E.3    Kong, H.4    Shin, E.5    Do, S.G.6
  • 24
    • 84872832551 scopus 로고    scopus 로고
    • Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome
    • Devaraj S, Yimam M, Brownell LA, Jialal I, Singh S, Jia Q. Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metab Syndr Relat Disord. 2013;11:35-40. doi:10.1089/met.2012.0066
    • (2013) Metab Syndr Relat Disord , vol.11 , pp. 35-40
    • Devaraj, S.1    Yimam, M.2    Brownell, L.A.3    Jialal, I.4    Singh, S.5    Jia, Q.6
  • 25
    • 33745714081 scopus 로고    scopus 로고
    • Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds
    • Tanaka M, Misawa E, Ito Y, Habara N, Nomaguchi K, Yamada M, et al. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol Pharm Bull 2006;29:1418-1422. doi: 10.1248/bpb.29.1418
    • (2006) Biol Pharm Bull , vol.29 , pp. 1418-1422
    • Tanaka, M.1    Misawa, E.2    Ito, Y.3    Habara, N.4    Nomaguchi, K.5    Yamada, M.6
  • 26
    • 67650568107 scopus 로고    scopus 로고
    • Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus
    • Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, et al. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. Phytomedicine: Int J Phytother Phytopharm 2009;16:856-863. doi: 10.1016/j.phymed.2009.02.014
    • (2009) Phytomedicine: Int J Phytother Phytopharm , vol.16 , pp. 856-863
    • Kim, K.1    Kim, H.2    Kwon, J.3    Lee, S.4    Kong, H.5    Im, S.A.6
  • 27
    • 0024489657 scopus 로고
    • Aloe vera and gibberellin. Anti-inflammatory activity in diabetes
    • Davis RH, Maro NP. Aloe vera and gibberellin. Anti-inflammatory activity in diabetes. J Am Podiatr Med Assoc 1989;79:24-26. doi: 10.7547/87507315-79-1-24
    • (1989) J Am Podiatr Med Assoc , vol.79 , pp. 24-26
    • Davis, R.H.1    Maro, N.P.2
  • 28
    • 77957224479 scopus 로고    scopus 로고
    • Wound healing in diabetes mellitus: Traditional treatment modalities
    • Laitiff AA, Teoh SL, Das S. Wound healing in diabetes mellitus: traditional treatment modalities. La Clinica Ter 2010;161:359-364.
    • (2010) La Clinica ter , vol.161 , pp. 359-364
    • Laitiff, A.A.1    Teoh, S.L.2    Das, S.3
  • 29
    • 84858952953 scopus 로고    scopus 로고
    • Effects of the blended fibroin/aloe gel film on wound healing in streptozotocin-induced diabetic rats
    • Inpanya P, Faikrua A, Ounaroon A, Sittichokechaiwut A, Viyoch J. Effects of the blended fibroin/aloe gel film on wound healing in streptozotocin-induced diabetic rats. Biomed Mater 2012;7:035008. doi: 10.1088/1748-6041/7/3/035008
    • (2012) Biomed Mater , vol.7
    • Inpanya, P.1    Faikrua, A.2    Ounaroon, A.3    Sittichokechaiwut, A.4    Viyoch, J.5
  • 30
    • 77949497635 scopus 로고    scopus 로고
    • Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats
    • Jain N, Vijayaraghavan R, Pant SC, Lomash V, Ali M. Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats. J Pharm Pharmacol. 2010;62:115-123. doi: 10.1211/jpp.62.01.0013
    • (2010) J Pharm Pharmacol , vol.62 , pp. 115-123
    • Jain, N.1    Vijayaraghavan, R.2    Pant, S.C.3    Lomash, V.4    Ali, M.5
  • 31
    • 0347949588 scopus 로고    scopus 로고
    • Effect of Aloe vera (L) Burm fil leaf gel and pulp extracts on kidney in type-II diabetic rat models
    • Bolkent S, Akev N, Ozsoy N, Sengezer-Inceli M, Can A, Alper O, et al. Effect of Aloe vera (L.) Burm. fil. leaf gel and pulp extracts on kidney in type-II diabetic rat models. Indian J Exp Biol 2004;42:48-52.
    • (2004) Indian J Exp Biol , vol.42 , pp. 48-52
    • Bolkent, S.1    Akev, N.2    Ozsoy, N.3    Sengezer-Inceli, M.4    Can, A.5    Alper, O.6
  • 32
    • 16644369717 scopus 로고    scopus 로고
    • Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models
    • Can A, Akev N, Ozsoy N, Bolkent S, Arda BP, Yanardag R, et al. Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol Pharm Bull 2004;27:694-698. doi: 10.1248/bpb.27.694
    • (2004) Biol Pharm Bull , vol.27 , pp. 694-698
    • Can, A.1    Akev, N.2    Ozsoy, N.3    Bolkent, S.4    Arda, B.P.5    Yanardag, R.6
  • 33
    • 0029349542 scopus 로고
    • Lipid profile and its relation to fasting insulin level in non-insulin dependent diabetes mellitus (NIDDM)
    • Uddin F, Miah AK. Lipid profile and its relation to fasting insulin level in non-insulin dependent diabetes mellitus (NIDDM). Bangladesh Med Res Counc Bull 1995;21:64-72.
    • (1995) Bangladesh Med Res Counc Bull , vol.21 , pp. 64-72
    • Uddin, F.1    Miah, A.K.2
  • 34
    • 1442326783 scopus 로고    scopus 로고
    • The effect of glycemic control in type 2 diabetic patients with diabetes-related dyslipidemia
    • Abdel-Gayoum AG. The effect of glycemic control in type 2 diabetic patients with diabetes-related dyslipidemia. Saudi Med J 2004;25:207-211.
    • (2004) Saudi Med J , vol.25 , pp. 207-211
    • Abdel-Gayoum, A.G.1
  • 35
    • 45849117276 scopus 로고    scopus 로고
    • Patterns of lipid changes among type 2 diabetes patients in Sudan
    • Elnasri HA, Ahmed AM. Patterns of lipid changes among type 2 diabetes patients in Sudan. East Mediterr Health J 2008;14:314-324.
    • (2008) East Mediterr Health J , vol.14 , pp. 314-324
    • Elnasri, H.A.1    Ahmed, A.M.2
  • 36
    • 77953821528 scopus 로고    scopus 로고
    • Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies
    • Emerging Risk Factors C, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 2010;375:2215-2222. doi: 10.1016/S0140-6736(10)60484-9
    • (2010) Lancet , vol.375 , pp. 2215-2222
    • Emerging Risk Factors, C.1    Sarwar, N.2    Gao, P.3    Seshasai, S.R.4    Gobin, R.5    Kaptoge, S.6
  • 37
    • 33645054804 scopus 로고    scopus 로고
    • Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes
    • Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 2006;33:232-237. doi:10.1111/j.1440-1681.2006.04351.x
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 232-237
    • Rajasekaran, S.1    Ravi, K.2    Sivagnanam, K.3    Subramanian, S.4
  • 38
    • 0001760557 scopus 로고    scopus 로고
    • Antidiabetic activity of Aloe vera L juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide
    • Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 1996;3:245-248. doi: 10.1016/S0944-7113(96)80061-4.
    • (1996) Phytomedicine , vol.3 , pp. 245-248
    • Bunyapraphatsara, N.1    Yongchaiyudha, S.2    Rungpitarangsi, V.3    Chokechaijaroenporn, O.4
  • 39
    • 84858151895 scopus 로고    scopus 로고
    • Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial
    • Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med 2012;78:311-316. doi: 10.1055/s-0031-1280474
    • (2012) Planta Med , vol.78 , pp. 311-316
    • Huseini, H.F.1    Kianbakht, S.2    Hajiaghaee, R.3    Dabaghian, F.H.4
  • 40
    • 0032854467 scopus 로고    scopus 로고
    • Aloe vera: A systematic review of its clinical effectiveness
    • Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-828.
    • (1999) Br J Gen Pract , vol.49 , pp. 823-828
    • Vogler, B.K.1    Ernst, E.2


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