Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy

Osteoarthritis and Cartilage

Volumn 23, Issue 11, 2015, Pages 1906-1914

  Larsson, S ^a   Englund, M ^a,b   Struglics, A ^a   Lohmander, L S ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Biomarkers; Cytokines; Meniscus injury; Osteoarthritis; Patient reported outcomes; Synovial fluid

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGE; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE COURSE; EXPLORATORY RESEARCH; FEMUR; FOLLOW UP; GENDER; HIGH RISK PATIENT; HUMAN; IMMUNOASSAY; JOINT CAVITY; KNEE INJURY AND OSTEOARTHRITIS OUTCOME SCORE; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MEDICAL SOCIETY; MENISCECTOMY; OSTEOPHYTE; PATELLOFEMORAL JOINT; PATIENT ASSESSMENT; PRACTICE GUIDELINE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN DETERMINATION; RATING SCALE; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RETROSPECTIVE STUDY; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SYNOVIAL FLUID LEVEL; TIBIA; AGED; CHILD; COMPLICATION; FEMALE; KNEE INJURY; KNEE MENISCUS; MALE; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POSTOPERATIVE PERIOD; PRESCHOOL CHILD; PROGNOSIS; RADIOGRAPHY; SURGERY; SYNOVIAL FLUID; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; KNEE INJURIES; MALE; MENISCI, TIBIAL; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POSTOPERATIVE PERIOD; PROGNOSIS; RETROSPECTIVE STUDIES; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84945310378     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.05.035     Document Type: Article

References (31)

1. Lohmander L.S., Englund P.M., Dahl L.L., Roos E.M. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 2007, 35:1756-1769.
2. Roos H., Lauren M., Adalberth T., Roos E.M., Jonsson K., Lohmander L.S. Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. Arthritis Rheum 1998, 41:687-693.
3. Englund M., Roos E.M., Lohmander L.S. Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls. Arthritis Rheum 2003, 48:2178-2187.
4. Dougados M. Synovial fluid cell analysis. Baillieres Clin Rheumatol 1996, 10:519-534.
5. Tsuchida A.I., Beekhuizen M., Rutgers M., van Osch G.J., Bekkers J.E., Bot A.G., et al. Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther 2012, 14:R262.
6. Livshits G., Zhai G., Hart D.J., Kato B.S., Wang H., Williams F.M., et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford Study. Arthritis Rheum 2009, 60:2037-2045.
7. Venn G., Nietfeld J.J., Duits A.J., Brennan F.M., Arner E., Covington M., et al. Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis. Arthritis Rheum 1993, 36:819-826.
8. Englund M., Lohmander L.S. Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum 2004, 50:2811-2819.
9. Larsson S., Englund M., Struglics A., Lohmander L.S. Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis. Arthritis Res Ther 2010, 12:R230.
10. Larsson S., Englund M., Struglics A., Lohmander L.S. The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study. Osteoarthritis Cartilage 2012, 20:388-395.
11. Altman R.D., Hochberg M., Murphy W.A., Wolfe F., Lequesne M. Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage 1995, 3(Suppl A):3-70.
12. Englund M., Lohmander L.S. Patellofemoral osteoarthritis coexistent with tibiofemoral osteoarthritis in a meniscectomy population. Ann Rheum Dis 2005, 64:1721-1726.
13. Roos E.M., Roos H.P., Lohmander L.S., Ekdahl C., Beynnon B.D. Knee Injury and Osteoarthritis Outcome Score (KOOS)-development of a self-administered outcome measure. J Orthop Sports Phys Ther 1998, 28:88-96.
14. Roos E.M., Roos H.P., Ekdahl C., Lohmander L.S. Knee injury and Osteoarthritis Outcome Score (KOOS)-validation of a Swedish version. Scand J Med Sci Sports 1998, 8:439-448.
15. Roos E.M., Lohmander L.S. The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes 2003, 1:64.
16. Struglics A., Larsson S., Kumahashi N., Frobell R., Lohmander L.S. Changes in synovial fluid and serum cytokines and ARGS-aggrecan, and urine CTX-II and NTX-I over five years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial. Arthritis Rheumatol 2015, In press, accepted manuscript, available online 24 April 2015.
17. Faraggi D., Reiser B. Estimation of the area under the ROC curve. Stat Med 2002, 21:3093-3106.
18. Roos E.M., Bremander A.B., Englund M., Lohmander L.S. Change in self-reported outcomes and objective physical function over 7 years in middle-aged subjects with or at high risk of knee osteoarthritis. Ann Rheum Dis 2008, 67:505-510.
19. Chockalingam P.S., Glasson S.S., Lohmander L.S. Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation. Osteoarthritis Cartilage 2013, 21:339-345.
20. Midwood K., Sacre S., Piccinini A.M., Inglis J., Trebaul A., Chan E., et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med 2009, 15:774-780.
21. Cameron M., Buchgraber A., Passler H., Vogt M., Thonar E., Fu F., et al. The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations. Am J Sports Med 1997, 25:751-754.
22. Irie K., Uchiyama E., Iwaso H. Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee. Knee 2003, 10:93-96.
23. Higuchi H., Shirakura K., Kimura M., Terauchi M., Shinozaki T., Watanabe H., et al. Changes in biochemical parameters after anterior cruciate ligament injury. Int Orthop 2006, 30:43-47.
24. Swärd P., Frobell R., Englund M., Roos H., Struglics A. Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis)-a cross-sectional analysis. Osteoarthritis Cartilage 2012, 20:1302-1308.
25. Malfait A.M., Tortorella M., Thompson J., Hills R., Meyer D.M., Jaffee B.D., et al. Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation. Osteoarthritis Cartilage 2009, 17:627-635.
26. Stannus O., Jones G., Cicuttini F., Parameswaran V., Quinn S., Burgess J., et al. Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage 2010, 18:1441-1447.
27. Orita S., Koshi T., Mitsuka T., Miyagi M., Inoue G., Arai G., et al. Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee. BMC Musculoskelet Disord 2011, 12:144.
28. Simkin P.A. Assessing biomarkers in synovial fluid: consider the kinetics of clearance. Osteoarthritis Cartilage 2013, 21:7-9.
29. Kapoor M., Martel-Pelletier J., Lajeunesse D., Pelletier J.P., Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 2011, 7:33-42.
30. Kraus V.B., Birmingham J., Stabler T.V., Feng S., Taylor D.C., Moorman C.T., et al. Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthritis Cartilage 2012, 20:271-278.
31. Karsdal M.A., Christiansen C., Ladel C., Henriksen K., Kraus V.B., Bay-Jensen A.C. Osteoarthritis-a case for personalized health care?. Osteoarthritis Cartilage 2014, 22:7-16.