The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Yang, Lan ^a,b   Wang, Youyuan ^c   Guo, Lvhua ^b   Wang, Liping ^b   Chen, Weiliang ^c   Shi, Bin ^a  

^a Wuhan University   (China)

^b STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY   (China)

^c SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; PROTEIN P53; SMALL INTERFERING RNA; NOS2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CONTROLLED STUDY; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SURVIVAL RATE; TUMOR GROWTH; ADULT; AGED; BIOSYNTHESIS; CARCINOGENESIS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; MIDDLE AGED; MOUTH TUMOR; PATHOLOGY; PROGNOSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL ANALYSIS;

ADULT; AGED; BIOMARKERS, TUMOR; CARCINOGENESIS; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NITRIC OXIDE SYNTHASE TYPE II; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84945307839     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/637853     Document Type: Article

References (32)

1. H. H. H.W. Schmidt and U. Walter, "NO at work, " Cell, vol. 78, no. 6, pp. 919-925, 1994.
2. W. Xu, L.Z. Liu, M. Loizidou, M. Ahmed, and I.G. Charles, "The role of nitric oxide in cancer, " Cell Research, vol. 12, no. 5-6, pp. 311-320, 2002.
3. S. K. Choudhari, M. Chaudhary, S. Bagde, A. R. Gadbail, and V. Joshi, "Nitric oxide and cancer: a review, " World Journal of Surgical Oncology, vol. 11, article 118, 2013.
4. M. Lechner, P. Lirk, and J. Rieder, "Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin, " Seminars in Cancer Biology, vol. 15, no. 4, pp. 277-289, 2005.
5. P. A. Brennan, S. Dennis, D. Poller, M. Quintero, R. Puxeddu, and G. J. Thomas, "Inducible nitric oxide synthase: correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma, " Head & Neck, vol. 30, no. 2, pp. 208-214, 2008.
6. M. Vakkala, K. Kahlos, E. Lakari, P. Pääkkö, V. Kinnula, and Y. Soini, "Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas, " Clinical Cancer Research, vol. 6, no. 6, pp. 2408-2416, 2000.
7. P. A. Brennan, S. Sharma, J. R. Bowden, and T. Umar, "Expression of inducible nitric oxide sythase in bone metastases, " European Journal of Surgical Oncology, vol. 29, no. 7, pp. 619-623, 2003.
8. H. Broholm, I. Rubin, A. Kruse et al., "Nitric oxide synthase expression and enzymatic activity in human brain tumors, " Clinical Neuropathology, vol. 22, no. 6, pp. 273-281, 2003.
9. L. Speranza, M. A. De Lutiis, Y. B. Shaik et al., "Localization and activity of iNOS in normal human lung tissue and lung cancer tissue, " International Journal of BiologicalMarkers, vol. 22, no. 3, pp. 226-231, 2007.
10. S. T. Connelly, M. Macabeo-Ong, N. Dekker, R. C. K. Jordan, and B. L. Schmidt, "Increased nitric oxide levels and iNOS overexpression in oral squamous cell carcinoma, " Oral Oncology, vol. 41, no. 3, pp. 261-267, 2005.
11. K. Sappayatosok, Y. Maneerat, S. Swasdison et al., "Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in oral squamous cell carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation, " Medicina Oral, Patologia Oral y Cirugia Bucal, vol. 14, no. 7, pp. E319-E324, 2009.
12. W.-L. Chen, S.-G. Zeng, H.-G. Li, H.-Z. Huang, and C.-B. Pan, "Expression of inducible nitric oxide synthase mRNA in squamous cell carcinoma of tongue, " Ai Zheng, vol. 21, no. 3, pp. 314-318, 2002.
13. L. E. Giono and J. J. Manfredi, "The p53 tumor suppressor participates in multiple cell cycle checkpoints, " Journal of Cellular Physiology, vol. 209, no. 1, pp. 13-20, 2006.
14. K. T. Bieging, S. S. Mello, and L. D. Attardi, "Unravelling mechanisms of p53-mediated tumour suppression, " Nature Reviews Cancer, vol. 14, no. 5, pp. 359-370, 2014.
15. W. E. Mercer, "Cell cycle regulation and the p53 tumor suppressor protein, " Critical Reviews in Eukaryotic Gene Expression, vol. 2, no. 3, pp. 251-263, 1992.
16. L. Weisz, A. Damalas, M. Liontos et al., "Mutant p53 enhances nuclear factor B activation by tumor necrosis factor in cancer cells, " Cancer Research, vol. 67, no. 6, pp. 2396-2401, 2007.
17. A. Zalcenstein, L. Weisz, P. Stambolsky, J. Bar, V. Rotter, andM. Oren, "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53, " Oncogene, vol. 25, no. 3, pp. 359-369, 2006.
18. D. P. Liu, H. Song, and Y. Xu, "A common gain of function of p53 cancer mutants in inducing genetic instability, " Oncogene, vol. 29, no. 7, pp. 949-956, 2010.
19. S. Strano, S. Dell'Orso, S. Di Agostino, G. Fontemaggi, A. Sacchi, and G. Blandino, "Mutant p53: an oncogenic transcription factor, " Oncogene, vol. 26, no. 15, pp. 2212-2219, 2007.
20. B. Leroy, L. Girard, A. Hollestelle, J. D. Minna, A. F. Gazdar, and T. Soussi, "Analysis of TP53 mutation status in human cancer cell lines: a reassessment, " Human Mutation, vol. 35, no. 6, pp. 756-765, 2014.
21. E. Gochman, J. Mahajna, P. Shenzer et al., "The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans, " Acta Histochemica, vol. 114, no. 8, pp. 827-835, 2012.
22. S. Strano, S. Dell'Orso, A. M. Mongiovi et al., "Mutant p53 proteins: between loss and gain of function, " Head and Neck, vol. 29, no. 5, pp. 488-496, 2007.
23. A. C. Abrahao, B. V. Bonelli, F. D. Nunes, E. P. Dias, and M. G. Cabral, "Immunohistochemical expression of p53, p16 and hTERT in oral squamous cell carcinoma and potentially malignant disorders, " Brazilian Oral Research, vol. 25, no. 1, pp. 34-41, 2011.
24. M. Gasco and T. Crook, "The p53 network in head and neck cancer, " Oral Oncology, vol. 39, no. 3, pp. 222-231, 2003.
25. L. R. de Oliveira, A. Ribeiro-Silva, and S. Zucoloto, "Prognostic impact of p53 and p63 immunoexpression in oral squamous cell carcinoma, " Journal of Oral Pathology andMedicine, vol. 36, no. 4, pp. 191-197, 2007.
26. A. C. Abrahao, B. V. Bonelli, F. D. Nunes, E. P. Dias, and M. G. Cabral, "Immunohistochemical expression of p53, p16 and hTERT in oral squamous cell carcinoma and potentially malignant disorders, " Brazilian Oral Research, vol. 25, no. 1, pp. 34-41, 2011.
27. N. Oridate, A. Homma, E. Higuchi et al., "p53 expression in concurrent chemoradiotherapy with docetaxel for head and neck squamous cell carcinoma, " Auris Nasus Larynx, vol. 36, no. 1, pp. 57-63, 2009.
28. A. Moon, K. Y. Won, J. Y. Lee, I. Kang, and S.-K. Lee, "Expression of BDNF, TrkB, and p53 in early-stage squamous cell carcinoma of the uterine cervix, " Pathology, vol. 43, no. 5, pp. 453-458, 2011.
29. D. W. Davis, D. A. Weidner, A. Holian, and D. J. McConkey, "Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung, " Journal of Experimental Medicine, vol. 192, no. 6, pp. 857-869, 2000.
30. M. Matsumoto, M. Furihata, A. Kurabayashi, K. Araki, S. Sasaguri, and Y. Ohtsuki, "Association between inducible nitric oxide synthase expression and p53 status in human esophageal squamous cell carcinoma, " Oncology, vol. 64, no. 1, pp. 90-96, 2003.
31. V. Kostourou, J. E. Cartwright, A. P. Johnstone et al., "The role of tumour-derived iNOS in tumour progression and angiogenesis, " British Journal of Cancer, vol. 104, no. 1, pp. 83-90, 2011.
32. L. L. Ma, W. J. Sun, Z. Wang, G. Y. Zh, P. Li, and S.B. Fu, "Effects of silencing ofmutant p53 gene in human lung adenocarcinoma cell line Anip973, " Journal of Experimental and Clinical Cancer Research, vol. 25, no. 4, pp. 585-592, 2006.