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Volumn 41, Issue 4, 2016, Pages 659-665

Forsythiaside A Exhibits Anti-inflammatory Effects in LPS-Stimulated BV2 Microglia Cells Through Activation of Nrf2/HO-1 Signaling Pathway

Author keywords

Forsythiaside A; Inflammatory mediators; LPS; NF B; Nrf2

Indexed keywords

ANTIINFLAMMATORY AGENT; FORSYTHIASIDE A; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRITE; PROSTAGLANDIN E2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; FORSYTHIASIDE; GLYCOSIDE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; NITRIC OXIDE;

EID: 84945299296     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1731-x     Document Type: Article
Times cited : (81)

References (27)
  • 1
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson’s disease: a target for neuroprotection?
    • COI: 1:CAS:528:DC%2BD1MXks1Sis70%3D, PID: 19296921
    • Hirsch EC, Hunot S (2009) Neuroinflammation in Parkinson’s disease: a target for neuroprotection? Lancet Neurol 8:382–397
    • (2009) Lancet Neurol , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 2
    • 33845211714 scopus 로고    scopus 로고
    • Neuroinflammation, oxidative stress and the pathogenesis of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD28Xht12ksb3J, PID: 18060039
    • Mosley RL, Benner EJ, Kadiu I, Thomas M, Boska MD, Hasan K et al (2006) Neuroinflammation, oxidative stress and the pathogenesis of Parkinson’s disease. Clin Neurosci Res 6:261–281
    • (2006) Clin Neurosci Res , vol.6 , pp. 261-281
    • Mosley, R.L.1    Benner, E.J.2    Kadiu, I.3    Thomas, M.4    Boska, M.D.5    Hasan, K.6
  • 3
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • COI: 1:CAS:528:DC%2BD3sXhtF2qug%3D%3D, PID: 12490568
    • Liu B, Hong JS (2003) Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304:1–7
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 4
    • 79958740022 scopus 로고    scopus 로고
    • Anti-inflammatory effects of fucoidan through inhibition of NF-kappa B, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells
    • COI: 1:CAS:528:DC%2BC3MXnsVyqsLs%3D, PID: 21570441
    • Park HY, Han MH, Park C, Jin CY, Kim GY, Choi IW et al (2011) Anti-inflammatory effects of fucoidan through inhibition of NF-kappa B, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. Food Chem Toxicol 49:1745–1752
    • (2011) Food Chem Toxicol , vol.49 , pp. 1745-1752
    • Park, H.Y.1    Han, M.H.2    Park, C.3    Jin, C.Y.4    Kim, G.Y.5    Choi, I.W.6
  • 5
    • 84857395835 scopus 로고    scopus 로고
    • Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells
    • COI: 1:CAS:528:DC%2BC38XjsVartbo%3D, PID: 22363816
    • Zhong LM, Zong Y, Sun L, Guo JZ, Zhang W, He Y et al (2012) Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. Plos One 7:e32195
    • (2012) Plos One , vol.7 , pp. e32195
    • Zhong, L.M.1    Zong, Y.2    Sun, L.3    Guo, J.Z.4    Zhang, W.5    He, Y.6
  • 6
    • 84930868899 scopus 로고    scopus 로고
    • Capillarisin suppresses lipopolysaccharide-induced inflammatory mediators in BV2 microglial cells by suppressing TLR4-mediated NF-kappaB and MAPKs signaling pathway
    • COI: 1:CAS:528:DC%2BC2MXms1Kju70%3D, PID: 25894679
    • Yu Z, Tang L, Chen L, Li J, Wu W, Hu C (2015) Capillarisin suppresses lipopolysaccharide-induced inflammatory mediators in BV2 microglial cells by suppressing TLR4-mediated NF-kappaB and MAPKs signaling pathway. Neurochem Res 40:1095–1101
    • (2015) Neurochem Res , vol.40 , pp. 1095-1101
    • Yu, Z.1    Tang, L.2    Chen, L.3    Li, J.4    Wu, W.5    Hu, C.6
  • 7
    • 84922105495 scopus 로고    scopus 로고
    • Biochanin A inhibits lipopolysaccharide-induced inflammatory cytokines and mediators production in BV2 microglia
    • COI: 1:CAS:528:DC%2BC2cXitVSitLrF, PID: 25432463
    • Zhang Y, Chen WA (2015) Biochanin A inhibits lipopolysaccharide-induced inflammatory cytokines and mediators production in BV2 microglia. Neurochem Res 40:165–171
    • (2015) Neurochem Res , vol.40 , pp. 165-171
    • Zhang, Y.1    Chen, W.A.2
  • 8
    • 38949090667 scopus 로고    scopus 로고
    • Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa
    • COI: 1:CAS:528:DC%2BD1cXhsFOrtrg%3D, PID: 18237475
    • Qu H, Zhang Y, Wang Y, Li B, Sun W (2008) Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa. J Pharm Pharmacol 60:261–266
    • (2008) J Pharm Pharmacol , vol.60 , pp. 261-266
    • Qu, H.1    Zhang, Y.2    Wang, Y.3    Li, B.4    Sun, W.5
  • 9
    • 79956069931 scopus 로고    scopus 로고
    • Neuroprotective effect of forsythiaside against transient cerebral global ischemia in gerbil
    • COI: 1:CAS:528:DC%2BC3MXmtFanurg%3D, PID: 21501605
    • Kim JM, Kim S, Kim DH, Lee CH, Park SJ, Jung JW et al (2011) Neuroprotective effect of forsythiaside against transient cerebral global ischemia in gerbil. Eur J Pharmacol 660:326–333
    • (2011) Eur J Pharmacol , vol.660 , pp. 326-333
    • Kim, J.M.1    Kim, S.2    Kim, D.H.3    Lee, C.H.4    Park, S.J.5    Jung, J.W.6
  • 10
    • 84922004601 scopus 로고    scopus 로고
    • Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell
    • COI: 1:CAS:528:DC%2BC2cXhvVKmurjK, PID: 25344274
    • Huang C, Lin Y, Su H, Ye D (2015) Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell. Neurochem Res 40:27–35
    • (2015) Neurochem Res , vol.40 , pp. 27-35
    • Huang, C.1    Lin, Y.2    Su, H.3    Ye, D.4
  • 11
    • 84887951153 scopus 로고    scopus 로고
    • Forsythiaside attenuates lipopolysaccharide-induced inflammatory responses in the bursa of Fabricius of chickens by downregulating the NF-κB signaling pathway
    • COI: 1:CAS:528:DC%2BC2cXjs1Khur4%3D, PID: 24348786
    • Cheng G, Zhao Y, Li H, Wu Y, Li X, Han Q et al (2014) Forsythiaside attenuates lipopolysaccharide-induced inflammatory responses in the bursa of Fabricius of chickens by downregulating the NF-κB signaling pathway. Exp Ther Med 7:179–184
    • (2014) Exp Ther Med , vol.7 , pp. 179-184
    • Cheng, G.1    Zhao, Y.2    Li, H.3    Wu, Y.4    Li, X.5    Han, Q.6
  • 12
    • 84925397402 scopus 로고    scopus 로고
    • Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury
    • COI: 1:CAS:528:DC%2BC2MXltVWlt7k%3D, PID: 25797347
    • Pan C-W, Zhou G-Y, Chen W-L, Zhuge L, Jin L-X, Zheng Y et al (2015) Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury. Int Immunopharmacol 26:80–85
    • (2015) Int Immunopharmacol , vol.26 , pp. 80-85
    • Pan, C.-W.1    Zhou, G.-Y.2    Chen, W.-L.3    Zhuge, L.4    Jin, L.-X.5    Zheng, Y.6
  • 13
    • 84904121551 scopus 로고    scopus 로고
    • Protective effect of forsythiaside A on acute lung injure induced by lipopolysaccharide in mice
    • COI: 1:CAS:528:DC%2BC28Xjt1Wnurk%3D, PID: 24491055
    • Zhou L, Yang H, Ai Y, Xie Y, Fu Y (2014) Protective effect of forsythiaside A on acute lung injure induced by lipopolysaccharide in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:151–154
    • (2014) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.30 , pp. 151-154
    • Zhou, L.1    Yang, H.2    Ai, Y.3    Xie, Y.4    Fu, Y.5
  • 14
    • 84910046575 scopus 로고    scopus 로고
    • Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-kappaB pathways
    • COI: 1:CAS:528:DC%2BC2cXhvVSms77M, PID: 25459294
    • Park J, Min JS, Kim B, Chae UB, Yun JW, Choi MS et al (2015) Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-kappaB pathways. Neurosci Lett 584:191–196
    • (2015) Neurosci Lett , vol.584 , pp. 191-196
    • Park, J.1    Min, J.S.2    Kim, B.3    Chae, U.B.4    Yun, J.W.5    Choi, M.S.6
  • 16
    • 0036890739 scopus 로고    scopus 로고
    • Pathophysiology of bacterial meningitis: mechanism (s) of neuronal injury
    • COI: 1:CAS:528:DC%2BD38Xps1Krt78%3D, PID: 12424702
    • Scheld WM, Koedel U, Nathan B, Pfister H-W (2002) Pathophysiology of bacterial meningitis: mechanism (s) of neuronal injury. J Infect Dis 186:S225–S233
    • (2002) J Infect Dis , vol.186 , pp. S225-S233
    • Scheld, W.M.1    Koedel, U.2    Nathan, B.3    Pfister, H.-W.4
  • 17
    • 27444443028 scopus 로고    scopus 로고
    • Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation
    • PID: 15920727
    • Qin L, Li G, Qian X, Liu Y, Wu X, Liu B et al (2005) Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. Glia 52:78–84
    • (2005) Glia , vol.52 , pp. 78-84
    • Qin, L.1    Li, G.2    Qian, X.3    Liu, Y.4    Wu, X.5    Liu, B.6
  • 18
    • 20544468364 scopus 로고    scopus 로고
    • Minocycline inhibits LPS-induced retinal microglia activation
    • COI: 1:CAS:528:DC%2BD2MXlsl2ktL4%3D, PID: 15904993
    • Wang AL, Albert C, Lau LT, Lee C, Tso MO (2005) Minocycline inhibits LPS-induced retinal microglia activation. Neurochem Int 47:152–158
    • (2005) Neurochem Int , vol.47 , pp. 152-158
    • Wang, A.L.1    Albert, C.2    Lau, L.T.3    Lee, C.4    Tso, M.O.5
  • 19
    • 84920721006 scopus 로고    scopus 로고
    • Pierisformoside B exhibits neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells via the HO-1/Nrf2-mediated pathway
    • COI: 1:CAS:528:DC%2BC2MXislKntA%3D%3D, PID: 25529993
    • Im NK, Zhou W, Na M, Jeong GS (2015) Pierisformoside B exhibits neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells via the HO-1/Nrf2-mediated pathway. Int Immunopharmacol 24:353–360
    • (2015) Int Immunopharmacol , vol.24 , pp. 353-360
    • Im, N.K.1    Zhou, W.2    Na, M.3    Jeong, G.S.4
  • 20
    • 73449131129 scopus 로고    scopus 로고
    • Targeting p38 MAPK pathway for the treatment of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXjtleqtg%3D%3D, PID: 19951717
    • Munoz L, Ammit AJ (2010) Targeting p38 MAPK pathway for the treatment of Alzheimer’s disease. Neuropharmacology 58:561–568
    • (2010) Neuropharmacology , vol.58 , pp. 561-568
    • Munoz, L.1    Ammit, A.J.2
  • 21
    • 0036063103 scopus 로고    scopus 로고
    • Involvement of inflammatory cytokines in central nervous system injury
    • COI: 1:CAS:528:DC%2BD38Xlt1OitLY%3D, PID: 12126659
    • Wang CX, Shuaib A (2002) Involvement of inflammatory cytokines in central nervous system injury. Prog Neurobiol 67:161–172
    • (2002) Prog Neurobiol , vol.67 , pp. 161-172
    • Wang, C.X.1    Shuaib, A.2
  • 22
    • 34247880271 scopus 로고    scopus 로고
    • Resveratrol inhibits IL-1β-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
    • COI: 1:CAS:528:DC%2BD2sXks1Grsr0%3D, PID: 17404069
    • Shakibaei M, John T, Seifarth C, Mobasheri A (2007) Resveratrol inhibits IL-1β-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann N Y Acad Sci 1095:554–563
    • (2007) Ann N Y Acad Sci , vol.1095 , pp. 554-563
    • Shakibaei, M.1    John, T.2    Seifarth, C.3    Mobasheri, A.4
  • 23
    • 11144284089 scopus 로고    scopus 로고
    • Effect of AT1 receptor antagonism on vascular and circulating inflammatory mediators in SHR: role of NF-κB/IκB system
    • COI: 1:CAS:528:DC%2BD2MXhtVCqsLs%3D, PID: 15308481
    • Sanz-Rosa D, Oubina MP, Cediel E, de las Heras N, Vegazo O, Jimenez J et al (2005) Effect of AT1 receptor antagonism on vascular and circulating inflammatory mediators in SHR: role of NF-κB/IκB system. Am J Physiol Heart Circ Physiol 288:H111–H115
    • (2005) Am J Physiol Heart Circ Physiol , vol.288 , pp. H111-H115
    • Sanz-Rosa, D.1    Oubina, M.P.2    Cediel, E.3    de las Heras, N.4    Vegazo, O.5    Jimenez, J.6
  • 24
    • 78651259607 scopus 로고    scopus 로고
    • Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells
    • COI: 1:CAS:528:DC%2BC3MXktVShsw%3D%3D, PID: 21093515
    • Lee I-S, Lim J, Gal J, Kang JC, Kim HJ, Kang BY et al (2011) Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem Int 58:153–160
    • (2011) Neurochem Int , vol.58 , pp. 153-160
    • Lee, I.-S.1    Lim, J.2    Gal, J.3    Kang, J.C.4    Kim, H.J.5    Kang, B.Y.6
  • 25
    • 34447621801 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates cytoprotective effects of immunostimulation in microglia
    • COI: 1:CAS:528:DC%2BD2sXotlajsrk%3D, PID: 17632083
    • Lee S, Suk K (2007) Heme oxygenase-1 mediates cytoprotective effects of immunostimulation in microglia. Biochem Pharmacol 74:723–729
    • (2007) Biochem Pharmacol , vol.74 , pp. 723-729
    • Lee, S.1    Suk, K.2
  • 26
    • 55949120110 scopus 로고    scopus 로고
    • Activation of Nrf2-antioxidant signaling attenuates NF kappa B-inflammatory response and elicits apoptosis
    • COI: 1:CAS:528:DC%2BD1cXhtl2qtLfI, PID: 18694732
    • Li WG, Khor TO, Xu CJ, Shen GX, Jeong WS, Yu S et al (2008) Activation of Nrf2-antioxidant signaling attenuates NF kappa B-inflammatory response and elicits apoptosis. Biochem Pharmacol 76:1485–1489
    • (2008) Biochem Pharmacol , vol.76 , pp. 1485-1489
    • Li, W.G.1    Khor, T.O.2    Xu, C.J.3    Shen, G.X.4    Jeong, W.S.5    Yu, S.6
  • 27
    • 0034717329 scopus 로고    scopus 로고
    • Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
    • COI: 1:CAS:528:DC%2BD3cXjvFaisbc%3D, PID: 10821856
    • Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y et al (2000) Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023–16029
    • (2000) J Biol Chem , vol.275 , pp. 16023-16029
    • Ishii, T.1    Itoh, K.2    Takahashi, S.3    Sato, H.4    Yanagawa, T.5    Katoh, Y.6


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