Enzyme kinetics and inhibition of histone acetyltransferase KAT8

European Journal of Medicinal Chemistry

Volumn 105, Issue , 2015, Pages 289-296

  Wapenaar, Hannah ^a   Van Der Wouden, Petra E ^a   Groves, Matthew R ^a   Rotili, Dante ^b   Mai, Antonello ^b   Dekker, Frank J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Catalytic mechanism; Enzyme kinetics; Epigenetics; Histone acetylation; KAT8

Indexed keywords

ACETYL COENZYME A; ANACARDIC ACID; HISTONE ACETYLTRANSFERASE; HISTONE H4; LYSINE ACETYLTRANSFERASE 8; UNCLASSIFIED DRUG; ENZYME INHIBITOR; HISTONE; KAT8 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; INHIBITION CONSTANT; ISOTHERMAL TITRATION CALORIMETRY; ANTAGONISTS AND INHIBITORS; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; KINETICS; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYL COENZYME A; ANACARDIC ACIDS; BIOCATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84945264596     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.10.016     Document Type: Article

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