Spina bifida in fetus is associated with an altered pattern of DNA methylation in placenta

Journal of Human Genetics

Volumn 60, Issue 10, 2015, Pages 605-611

  Zhang, Xiaojuan ^a,b   Pei, Lijun ^c   Li, Runting ^a,b   Zhang, Wei ^d,e   Yang, Hua ^a   Li, Yongchao ^a,e   Guo, Yu ^a,e   Tan, Pingping ^a   Han, Jingdong J ^d,e   Zheng, Xiaoying ^c   Ma, Runlin Z ^a,b,e  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b ZHENGZHOU NORMAL UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DECITABINE; DIHYDROFOLATE REDUCTASE; DNA; GENOMIC DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN; TRIPARTITE MOTIF CONTAINING PROTEIN 26; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; TRIM26 PROTEIN, HUMAN;

ARTICLE; CHO CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; FEMALE; FETUS; FETUS MALFORMATION; GENETIC ASSOCIATION; GESTATIONAL AGE; HUMAN; HUMAN CELL; MALE; MOLECULAR PATHOLOGY; PHENOTYPE; PLACENTA; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SPINAL DYSRAPHISM; TRANSCRIPTION REGULATION; ANIMAL; CRICETULUS; GENETIC EPIGENESIS; GENETICS; HAMSTER; METABOLISM; PREGNANCY;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DNA METHYLATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; FEMALE; HUMANS; MALE; PLACENTA; PREGNANCY; SPINAL DYSRAPHISM;

EID: 84945253531     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2015.80     Document Type: Article

References (13)

1. Greene, N. D., Stanier, P.& Moore, G. E. The emerging role of epigenetic mechanisms in the etiology of neural tube defects. Epigenetics 6, 875-883 (2011).
2. Botto, L. D., Moore, C. A., Khoury, M. J.& Erickson, J. D. Neural-tube defects. N. Engl. J. Med. 341, 1509-1519 (1999).
3. Gu, X., Lin, L., Zheng, X., Zhang, T., Song, X., Wang, J. et al. High prevalence of NTDs in Shanxi Province: A combined epidemiological approach. Birth Defects Res. A Clin. Mol. Teratol. 79, 702-707 (2007).
4. Maccani, M. A.& Marsit, C. J. Epigenetics in the placenta. Am. J. Reprod. Immunol. 62, 78-89 (2009).
5. Larque, E., Ruiz-Palacios, M.& Koletzko, B. Placental regulation of fetal nutrient supply. Curr. Opin. Clin. Nutr. Metab. Care 16, 292-297 (2013).
6. Banister, C. E., Koestler, D. C., Maccani, M. A., Padbury, J. F., Houseman, E. A.& Marsit, C. J. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics 6, 920-927 (2011).
7. Suter, M., Ma, J., Harris, A., Patterson, L., Brown, K. A., Shope, C. et al. Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression. Epigenetics 6, 1284-1294 (2011).
8. Sandoval, J., Heyn, H., Moran, S., Serra-Musach, J., Pujana, M. A., Bibikova, M. et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics 6, 692-702 (2011).
9. Xia, K., Xue, H., Dong, D., Zhu, S., Wang, J., Zhang, Q. et al. Identification of the proliferation/differentiation switch in the cellular network of multicellular organisms. PLoS Comput. Biol. 2, e145 (2006).
10. Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L. et al. The tripartite motif family identifies cell compartments. EMBO J. 20, 2140-2151 (2001).
11. de Jong, S., van Eijk, K. R., Zeegers, D. W., Strengman, E., Janson, E., Veldink, J. H. et al. Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes. Eur. J. Hum. Genet. 20, 1004-1008 (2012).
12. Izzi, B., Van Geet, C.& Freson, K. Recent advances in GNAS epigenetic research of pseudohypoparathyroidism. Curr. Mol. Med. 12, 566-573 (2012).
13. Richard, N., Molin, A., Coudray, N., Rault-Guillaume, P., Jüppner, H.& Kottler, M. L. Paternal GNAS mutations lead to severe intrauterine growth retardation (IUGR) and provide evidence for a role of XLalphas in fetal development. J. Clin. Endocrinol. Metab. 98, E1549-E1556 (2013).