Hemagglutinin-neuraminidase balance influences the virulence phenotype of a recombinant H5N3 influenza a virus possessing a polybasic HA0 cleavage Site

Journal of Virology

Volumn 89, Issue 21, 2015, Pages 10724-10734

  Diederich, Sandra ^a,b   Berhane, Yohannes ^a   Embury Hyatt, Carissa ^a   Hisanaga, Tamiko ^a   Handel, Katherine ^a   Cottam Birt, Colleen ^a   Ranadheera, Charlene ^c   Kobasa, Darwyn ^c   Pasick, John ^a  

^a CANADIAN FOOD INSPECTION AGENCY   (Canada)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^c PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HN PROTEIN; INFLUENZA VIRUS HEMAGGLUTININ; OSELTAMIVIR; SIALIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHICKEN; CONTROLLED STUDY; GENE SEQUENCE; GENETIC REASSORTMENT; HEMAGGLUTININ GENE; INFLUENZA A VIRUS (H5N1); INFLUENZA A VIRUS (H5N3); INFLUENZA A VIRUS (H7N3); NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SEROCONVERSION; VIRUS GENOME; VIRUS MUTATION; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS SHEDDING; VIRUS TRANSMISSION; VIRUS VIRULENCE; ANIMAL; AVIAN INFLUENZA; DNA SEQUENCE; DOG; GENETICS; INFLUENZA A VIRUS; MDCK CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOGENICITY; VIRAL PLAQUE ASSAY; VIROLOGY; VIRULENCE;

ANIMALS; BASE SEQUENCE; CHICKENS; DOGS; GENOME, VIRAL; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA A VIRUS, H7N3 SUBTYPE; INFLUENZA IN BIRDS; MADIN DARBY CANINE KIDNEY CELLS; MOLECULAR SEQUENCE DATA; MUTATION; NEURAMINIDASE; OSELTAMIVIR; REASSORTANT VIRUSES; SEQUENCE ANALYSIS, DNA; VIRAL PLAQUE ASSAY; VIRULENCE;

EID: 84945236837     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01238-15     Document Type: Article

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