PCR array and protein array studies demonstrate that IL-1 β (interleukin-1 β) stimulates the expression and secretion of multiple cytokines and chemokines in human adipocytes

Archives of Physiology and Biochemistry

Volumn 121, Issue 5, 2015, Pages 187-193

  Alomar, Suliman Y ^a,b   Zaibi, Mohamed S ^c   Kępczyńska, Malgorzata A ^c   Gentili, Alessandra ^c   Alkhuriji, Afrah ^a   Mansour, Lamjad ^a   Dar, Javid Ahmed ^b   Trayhurn, Paul ^a,c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF BUCKINGHAM   (United Kingdom)

Author keywords

Adipose tissue; gene expression; inflammation; obesity

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 1BETA; MESSENGER RNA;

ADIPOCYTE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; PROCEDURES; PROTEIN MICROARRAY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOCYTES; CELLS, CULTURED; CHEMOKINES; CYTOKINES; HUMANS; INTERLEUKIN-1BETA; PROTEIN ARRAY ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84945206498     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.3109/13813455.2015.1087034     Document Type: Article

References (39)

1. Arita Y, Kihara S, Ouchi N, et al. (1999). Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun, 257:79-83.
2. Berg AH, Combs TP, Du X, et al. (2001). The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Med, 7:947-53.
3. Bertola A, Ciucci T, Rousseau D, et al. (2012). Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes, 61:2238-47.
4. Bing C. (2015). Is interleukin-1b a culprit in macrophage-adipocyte crosstalk in obesity? Adipocyte, 4:149-52.
5. Bluher M. (2009). Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes, 117:241-50.
6. Brestoff JR, Kim BS, Saenz SA, et al. (2015). Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature, 519:242-6.
7. Dahlman I, Elsen M, Tennagels N, et al. (2012). Functional annotation of the human fat cell secretome. Arch Physiol Biochem, 118:84-91.
8. Donath MY. (2014). Targeting inflammation in the treatment of type 2 diabetes: Time to start. Nature Rev Drug Discov, 13:465-76.
9. Fietta P, Costa E, Delsante G. (2014). Interleukins (ILs), a fascinating family of cytokines. Part I: ILs from IL-1 to IL-19. Theor Biol Forum, 107:13-45.
10. Frühbeck G, Gómez-Ambrosi J, Muruzabal FJ, Burrell MA. (2001). The adipocyte: A model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol, 280:E827-47.
11. Gao D, Bing C. (2011). Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1b via activation of MAPK signaling. J Cell Physiol, 226:2869-80.
12. Gao D, Madi M, Ding C, et al. (2014). Interleukin-1b mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am J Physiol Endocrinol Metab, 307:E289-304.
13. Hashimoto I, Wada J, Hida A, et al. (2006). Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. Obesity, 14:799-811.
14. Hotamisligil GS, Shargill NS, Spiegelman BM. (1993). Adipose expression of tumor necrosis factor-A-direct role in obesity-linked insulin resistance. Science, 259:87-91.
15. Hotamisligil GS. (2006). Inflammation and metabolic disorders. Nature, 444:860-67.
16. Hotta K, Funahashi T, Arita Y, et al. (2000). Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscl Thromb Vasc Biol, 20:1595-9.
17. Kopelman PG. (2000). Obesity as a medical problem. Nature, 404:635-43.
18. Lacasa D, Taleb S, Keophiphath M, et al. (2007). Macrophage-secreted factors impair human adipogenesis: Involvement of proinflammatory state in preadipocytes. Endocrinology, 148:868-77.
19. Lopalco G, Cantarini L, Vitale A, et al. (2015). Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: Premises, perils, and perspectives. Mediat Inflamm, 2015:194864.
20. Meijer K, de Vries M, Al-Lahham S, et al. (2011). Human primary adipocytes exhibit immune cell function: Adipocytes prime inflammation independent of macrophages. PLoS One, 6:e17154.
21. O'Hara A, Lim F-L, Mazzatti D, Trayhurn P. (2009). Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophageconditioned medium. Pflügers Arch Eur J Physiol, 458:1103-14.
22. O'Hara A, Lim F-L, Mazzatti DJ, Trayhurn P. (2012). Stimulation of inflammatory gene expression in human preadipocytes by macrophage-conditioned medium: Upregulation of IL-6 production by macrophage-derived IL-1b. Mol Cell Endocrinol, 349:239-47.
23. Ouchi N, Kihara S, Arita Y, et al. (1999). Novel modulator for endothelial adhesion molecules-Adipocyte-derived plasma protein adiponectin. Circulation, 100:2473-76.
24. Peeraully MR, Jenkins JR, Trayhurn P. (2004). NGF gene expression and secretion in white adipose tissue: Regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Am J Physiol Endocrinol Metab, 287:E331-9.
25. Pond CM. (2005). Adipose tissue and the immune system. Prost Leuk Essent Fatty Acids, 73:17-30.
26. Rajala MW, Obici S, Scherer PE, Rossetti L. (2003). Adipose-derived resistin and gut-derived resistin-like molecule-b selectively impair insulin action on glucose production. J Clin Invest, 111:225-30.
27. Rosen ED, Spiegelman BM. (2006). Adipocytes as regulators of energy balance and glucose homeostasis. Nature, 444:847-53.
28. Rosenow A, Noben JP, Bouwman FG, et al. (2013). Hypoxia-mimetic effects in the secretome of human preadipocytes and adipocytes. Biochim Biophys Acta, 1834:2761-71.
29. Sarraf P, Frederich RC, Turner EM, et al. (1997). Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia. J Exp Med, 185:171-5.
30. Simons PJ, van den Pangaart PS, Aerts JMFG, Boon L. (2007). Proinflammatory delipidizing cytokines reduce adiponectin secretion from human adipocytes without affecting adiponectin oligomerization. J Endocrinol, 192:289-99.
31. Trayhurn P, Beattie JH. (2001). Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ. Proc Nutr Soc, 60:329-39.
32. Trayhurn P. (2013). Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev, 93:1-21.
33. Wang B, Jenkins JR, Trayhurn P. (2005). Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: Integrated response to TNF-a. Am J Physiol Endocrinol Metab, 288:E731-40.
34. Wang B, Trayhurn P. (2006). Acute and prolonged effects of TNF-alpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture. Pflügers Arch Eur J Physiol, 452:418-27.
35. Wang B, Wood IS, Trayhurn P. (2008). PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes. Biochem Biophys Res Commun, 368:88-93.
36. Weisberg SP, McCann D, Desai M, et al. (2003). Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest, 112:1796-808.
37. Xu H, Barnes GT, Yang Q, et al. (2003). Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest, 112:1821-30.
38. Yamauchi T, Kamon J, Waki H, et al. (2001). The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Med, 7:941-6.
39. Yokota T, Oritani K, Takahashi I, et al. (2000). Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood, 96:1723-32.