A druggable pocket at the nucleocapsid/phosphoprotein interaction site of human respiratory syncytial virus

Journal of Virology

Volumn 89, Issue 21, 2015, Pages 11129-11143

  Ouizougun Oubari, Mohamed ^a,b   Pereira, Nelson ^c   Tarus, Bogdan ^d   Galloux, Marie ^d   Lassoued, Safa ^c   Fix, Jenna ^d   Tortorici, M Alejandra ^a,b   Sylviane Hoos, ^a   Baron, Bruno ^a   England, Patrick ^a   Desmaële, Didier ^e   Couvreur, Patrick ^e   Bontems, François ^c   Rey, Félix A ^a,b   Eléouët, Jean François ^d   Sizun, Christina ^c   Slama Schwok, Anny ^d   Duquerroy, Stéphane ^a,b,f  

^a INSTITUT PASTEUR   (France)

^b Institut Pasteur   (France)

^c INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^d INRA Institut National de la Recherche Agronomique   (France)

^e UNIV PARIS SUD   (France)

^f UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 CHLOROBENZYL) 1H PYRAZOLE 3,5 DICARBOXYLATE; 1 (2,4 DICHLOROBENZYL) 1H PYRAZOLE 3,5 DICARBOXYLATE; 1 (4 BROMOBENZYL) 1H PYRAZOLE 3,5 DICARBOXYLATE; 1 (4 FLUOROBENZYL) 1H PYRAZOLE 3,5 DICARBOXYLATE; 1 (BENZYL) 1H PYRAZOLE 3,5 DICARBOXYLATE; ANTIVIRUS AGENT; PHOSPHOPROTEIN; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; PHOTOPROTEIN; RED FLUORESCENT PROTEIN;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IN VITRO STUDY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS NUCLEOCAPSID; CALORIMETRY; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

ANTIVIRAL AGENTS; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LUMINESCENT PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NUCLEOCAPSID; PHOSPHOPROTEINS; PROTEIN CONFORMATION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; X-RAY DIFFRACTION;

EID: 84945174666     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01612-15     Document Type: Article

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