Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells

Oncotarget

Volumn 6, Issue 30, 2015, Pages 29428-29439

  Liu, Chunling ^a   Guo, Huan ^b   Cheng, Xinxin ^a   Shao, Mingming ^a   Wu, Chen ^a   Wang, Suhan ^b   Li, Hongmin ^a   Wei, Lixuan ^a   Gao, Yanning ^a   Tan, Wen ^a   Cheng, Shujun ^a   Wu, Tangchun ^b   Yu, Dianke ^a   Lin, Dongxin ^a  

^a CANCER HOSPITAL   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bronchial epithelial cell; Gene expression; MicroRNA expression; Neoplastic transformation; PM2.5

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 182; MICRORNA 185; UNCLASSIFIED DRUG; 3 ALPHA-BETA, 20 BETA-HYDROXYSTEROID DEHYDROGENASE; 3ALPHA(OR 20BETA) HYDROXYSTEROID DEHYDROGENASE; AIR POLLUTANT; CATION TRANSPORT PROTEIN; MIRN182 MICRORNA, HUMAN; PARTICULATE MATTER; PLASMINOGEN ACTIVATOR INHIBITOR 2; SLC30A1 PROTEIN, HUMAN; TUMOR MARKER;

3T3 CELL LINE; AIRBORNE PARTICLE; AKR1C1 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL ANALYSIS; BRONCHUS MUCOSA; COHORT ANALYSIS; COMPUTER ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; FIBROSARCOMA; GENE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; LUNG CARCINOGENESIS; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; PARTICLE SIZE; PARTICULATE MATTER; PILOT STUDY; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SERPINB2 GENE; SLC30A1 GENE; TUMOR XENOGRAFT; UPREGULATION; AIR POLLUTANT; ANIMAL; BAGG ALBINO MOUSE; BLOOD; BRONCHUS; CELL TRANSFORMATION; CHEMICALLY INDUCED; COMPUTER SIMULATION; DRUG EFFECTS; EPITHELIUM CELL; FIBROBLAST; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; PROCEDURES; TIME FACTOR; TOXICITY; TRANSPLANTATION; TUMOR CELL LINE;

20-HYDROXYSTEROID DEHYDROGENASES; AIR POLLUTANTS; ANIMALS; BIOMARKERS, TUMOR; BRONCHI; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COMPUTER SIMULATION; DOWN-REGULATION; EPITHELIAL CELLS; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; NIH 3T3 CELLS; ONCOGENES; PARTICULATE MATTER; PILOT PROJECTS; PLASMINOGEN ACTIVATOR INHIBITOR 2; TIME FACTORS; TRANSFECTION;

EID: 84945157906     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5005     Document Type: Article

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