Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

Pancreas

Volumn 45, Issue 6, 2016, Pages 863-869

  Walsh, Alex J ^a   Castellanos, Jason A ^b   Nagathihalli, Nagaraj S ^c,d,e   Merchant, Nipun B ^c,d,e   Skala, Melissa C ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d Division of Surgical Oncology   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

cellular metabolism; optical microscopy; organoids; pancreatic ductal adenocarcinoma

Indexed keywords

5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; CASPASE 3; CYTOKERATIN AE1; CYTOKERATIN AE3; GEMCITABINE; KI 67 ANTIGEN; PILARALISIB; SELUMETINIB; ANTINEOPLASTIC AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DRUG EFFECT; DRUG RESPONSE; FIBROBLAST; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; NONHUMAN; OPTICAL METABOLIC IMAGING; OXIDATION REDUCTION STATE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; ANIMAL; CARCINOMA, PANCREATIC DUCTAL; CELL SURVIVAL; DIAGNOSTIC IMAGING; DRUG EFFECTS; KNOCKOUT MOUSE; MULTIPHOTON MICROSCOPY; PANCREATIC NEOPLASMS; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TIME FACTOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, PANCREATIC DUCTAL; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; OPTICAL IMAGING; ORGANOIDS; PANCREATIC NEOPLASMS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 84945151926     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000543     Document Type: Article

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