Poor responders in IVF - Is there any evidence-based treatment for them?

Neuroendocrinology Letters

Volumn 36, Issue 3, 2015, Pages 209-213

  Szymusik, Iwona ^a   Marianowski, Piotr ^a   Zygula, Aleksandra ^a   Wielgos, Miroslaw ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Bologna criteria; Evidence based medicine; IVF outcome; Poor ovarian response; Poor responders; POR interventions

Indexed keywords

ACETYLSALICYLIC ACID; ANDROGEN; ESTRADIOL; GONADORELIN ANTAGONIST; GROWTH HORMONE; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE;

CLINICAL PROTOCOL; CONSENSUS; EVIDENCE BASED PRACTICE; FERTILIZATION IN VITRO; HUMAN; LABORATORY TEST; META ANALYSIS (TOPIC); NONHUMAN; OVARIAN RESERVE; OVARY INSUFFICIENCY; PREVALENCE; REVIEW; RISK FACTOR; TREATMENT RESPONSE; ADULT; EVIDENCE BASED MEDICINE; FEMALE; INFERTILITY, FEMALE; PHYSIOLOGY; PREGNANCY; PROCEDURES;

ADULT; EVIDENCE-BASED MEDICINE; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; OVARIAN RESERVE; PREGNANCY;

EID: 84945126355     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. Baka S, Makrakis E, Tzanakaki D, Konidaris S, Hassiakos D, Moustakarias T, Creatsas G (2006). Poor responders in IVF: cancellation of a first cycle is not predictive of a subsequent failure. Ann N Y Acad Sci. 1092:418-425.
2. Berkkanoglu M, Ozgur K (2010). What is the optimum maximal gonadotropin dosage used in microdose flare-up cycles in poor responders? Fertil Steril. 94:662-665.
3. Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB (2006). A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update. 12:685-718.
4. Broer SL, Mol BW, Hendriks D, Broekmans FJ (2009). The role of anti-Mullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril. 91:705-714.
5. Chai J, Lee VC, Yeung TW, Li RW, Ho PC, Ng EH (2015). Live birth and cumulative live birth rates in expected poor ovarian responders defined by the Bologna criteria following IVF/ICSI treatment. PLoS One. 10(3): e01191
6. De Vos M, Devroey P, Fauser BC (2010). Primary ovarian insufficiency. Lancet. 376:911-21.
7. Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF (1992). Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod. 7(10): 1342-1346
8. Fan W, Li S, Chen Q, Huang Z, Ma Q, Wang Y (2013). Recombinant Luteinizing Hormone supplementation in poor responders undergoing IVF: a systematic review and meta-analysis. Gynecol Endocrinol. 29(4): 278-284
9. Ferraretti AP, La Marca A, Fauser BCMJ, Tarlatzis B, Nargund G, Gianaroli L (2011). ESHRE consensus on the definition of "poor response" to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 26(7): 1616-1624
10. Galey-Fontaine J, Cedrin-Durnerin I, Chaibi R, Massin N, Hugues JN (2005). Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders. Reprod Biomed Online. 10: 94-99.
11. Garcia JE, Jones GS, Acosta AA, Wright G (1983). HMG/hCG follicular maturation for oocytes aspiration: phase II, 1981. Fertil Steril. 39:174-179.
12. Gelbaya TA, Kyrgiou M, Li TC, Stern C, Nardo LG (2007). Low-dose aspirin for in vitro fertilization: a systematic review and metaanalysis. Hum Reprod Update. 13:357-364
13. Griesinger G, Diedrich K, Tarlatzis BC, Kolibianakis EM (2006). GnRH-antagonists in ovarian stimulation for IVF inpatients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a metaanalysis. Reprod BioMed Online. 13:628-638.
14. IVF Wordwide Survey. Poor responders: how to define, diagnose and treat? Newsletter-August 8, 2010 (www.IVF-Worlwide.com).
15. Kolibianakis EM, Venetis CA, Diedrich K, Tarlatzis BC, Griesinger G (2009). Addition of growth hormone to gonadotrophins in ovarian stimulation of poor responders treated by in-vitro fertilization: a systematic review and meta-analysis. Hum Reprod Update. 15(6): 613-22.
16. Kyrou D, Kolibianakis E, Venetis CA, Papanikolaou EG, Bontis J, Tarlatzis BC (2009). How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril. 91:749-766.
17. La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio AC, Stabile G et al. (2010). Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update. 16:113-130.
18. Lehert P, Kolibianakis EM, Venetis CA, Schertz J, Saunders H, Arriagada P, Copt S et al. (2014). Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and metaanalysis. Reprod Biol Endocrinol. 12:17.
19. Luo S, Li S, Li X, Qin L, Jin S (2014). Effect of pretreatment with transdermal testosterone on poor ovarian responders undergoing IVF/ICSI: A meta-analysis. Exp Ther Med. 8(1): 187-194.
20. Maheshwari A, Stofberg L, Bhattacharya S (2007). Effect of overweight and obesity on assisted reproductive technology - a systematic review. Hum Reprod Update. 13:433-444.
21. Orvieto R, Meltcer S, Nahum R, Rabinson J, Anteby EY, Ashkenazi J (2009). The influence of body mass index on in vitro fertilization outcome. Int J Gynaecol Obstet. 104(1): 53-5.
22. Oudendijk JF, Yarde F, Eijkemans MJ, Broekmans FJ, Broer SL (2012). The poor responder in IVF: is the prognosis always poor?: a systematic review. Hum Reprod Update. 18(1): 1-11.
23. Pandian Z, McTavish AR, Aucott L, Hamilton MP, Bhattacharya S (2010). Intervention for poor responders to controlled ovarian hyperstimulation in IVF. Cochrane Database Syst Rev. 1: CD004379.
24. Polyzos NP, Blockeel C, Verpoest W, De Vos M, Stoop D, Vloeberghs V, Camus M, et al. (2012). Live birth rates following natural cycle IVF in women with poor ovarian response according to the Bologna criteria. Hum Reprod. 27(12): 3481-6.
25. Polyzos NP, Devos M, Humaidan P, Stoop D, Ortega-Hrepich C, Devroey P, Tournaye H (2013). Corifollitropin alfa followed by rFSH in a GnRH antagonist protocol for poor ovarian responder patients: an observational pilot study. Fertil Steril. 99(2): 422-6.
26. Polyzos NP, Devroey P (2011). A systematic review of randomized trials for the treatment of poor ovarian responders: is there any light at the end of the tunnel? Fertil Steril. 96(5): 1058-61.
27. Polyzos NP, Nwoye M, Corona R, Blockeel C, Stoop D, Haentjens P, Camus M, et al. (2014). Live birth rates in Bologna poor responders treated with ovarian stimulation for IVF/ICSI. Reprod Biomed Online. 28(4): 469-74.
28. Polyzos NP, Tournaye H (2014). Poor ovarian responders: to meta-analyse or not, that is the question. Hum Reprod. 29:634-635
29. Pu D, Wu J, Liu J (2011). Comparisons of GnRH antagonist versus GnRH agonist protocol in poor ovarian responders undergoing IVF. Hum Reprod. 26:2742-2749
30. Reynolds KA, Omurtag KR, Jimenez PT, Rhee JS, Tuuli MG, Jungheim ES (2013). Cycle cancellation and pregnancy after luteal estradiol priming in women defined as poor responders: a systematic review and meta-analysis. Hum Reprod. 28:2981-2989
31. Sunkara SK, Coomarasamy A (2011). Androgen pretreatment in poor responders undergoing controlled ovarian stimulation and in vitro fertilization treatment. Fertil Steril. 95:73-75.
32. Timeva T, Milachich T, Antonova I, Arabaji T, Shterev A, Omar HA (2006). Correlation between number of retrieved oocytes and pregnancy rate after in vitro fertilization / intracytoplasmic sperm infection. ScientificWorld Journal. 6:686-690.
33. Ubaldi F, Vaiarelli A, D'Anna R, Rienzi L (2014). Management of poor responders in IVF: is there anything new? Biomed Res Int. 2014:352098.
34. Ulug U, Ben-Shlomo I, Turan E, Erden HF, Akman MA, Bahceci M (2003). Conception rates following assisted reproduction in poor responder patients: a retrospective study in 300 consecutive cycles. Reprod Biomed Online. 6:439-443.
35. Urman B, Yakin K (2012). DHEA for poor responders: can treatment be justified in the absence of evidence? Reprod Biomed Online. 25(2): 103-7.
36. Verhagen TE, Hendriks DJ, Bancsi LF, Mol BW, Broekmans FJ (2008). The accuracy of multivariate models predicting ovarian reserve and pregnancy after in vitro fertilization: a meta-analysis. Hum Reprod Update. 14:95-100.
37. Zou SH, Zhang P, Song DP, Li B, Wu RY (2008). Impact of antiovarian antibodies (AOA) on ovarian responsiveness in vitro fertilization and embryo transfer. Neuro Endocrinol Lett. 29(6): 949-52.