DHEA for poor responders: Can treatment be justified in the absence of evidence?

Reproductive BioMedicine Online

Volumn 25, Issue 2, 2012, Pages 103-107

  Urman, Bulent ^a,b   Yakin, Kayhan ^a,b  

^a AMERICAN HOSPITAL   (Turkey)

^b KOÇ UNIVERSITY   (Turkey)

Author keywords

assisted reproduction; dehydroepiandrosterone; diminished ovarian reserve; evidence based medicine; ovarian reserve; poor ovarian response

Indexed keywords

ANDROGEN; PRASTERONE;

ANDROGEN METABOLISM; BODY MASS; EVIDENCE BASED MEDICINE; HUMAN; NONHUMAN; OVARIAN RESERVE; OVARY CYCLE; OVULATION INDUCTION; PREDICTIVE VALUE; PREGNANCY RATE; PROGNOSIS; REVIEW; TREATMENT RESPONSE;

EID: 84864475317     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2012.05.009     Document Type: Note

References (38)

1. D. Barad, and N. Gleicher Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF Hum. Reprod. 21 2006 2845 2849
2. D. Barad, H. Brill, and N. Gleicher Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function J. Assist. Reprod. Genet. 24 2007 629 634
3. D.H. Barad, A. Weghofer, and N. Gleicher Dehydroepiandrosterone treatment of ovarian failure Fertil. Steril. 91 2009 e14 author reply e15
4. J.K. Bosdou, C.A. Venetis, E.M. Kolibianakis, K.A. Toulis, D.G. Goulis, L. Zepiridis, and B.C. Tarlatzis The use of androgens or androgen-modulating agents in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis Hum. Reprod. Update 18 2012 127 145
5. F.J. Broekmans, J. Kwee, D.J. Hendriks, B.W. Mol, and C.B. Lambalk A systematic review of tests predicting ovarian reserve and IVF outcome Hum. Reprod. Update 12 2006 685 718
6. F. Fabregues, J. Penarrubia, M. Creus, D. Manau, G. Casals, F. Carmona, and J. Balasch Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial Hum. Reprod. 24 2009 349 359
7. A.P. Ferraretti, A. La Marca, B.C. Fauser, B. Tarlatzis, G. Nargund, L. Gianaroli ESHRE working group on poor ovarian response (POR) definition ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria Hum. Reprod. 26 2011 1616 1624
8. T. Fleming Clinical trials: discerning hype from substance Ann. Intern. Med. 153 2010 400 406
9. N. Gleicher, and D.H. Barad Androgen priming before ovarian stimulation for IVF Hum. Reprod. 23 2008 2868 2870 author reply 2870-2871
10. N. Gleicher, and D.H. Barad Misplaced obsession with prospectively randomized studies Reprod. Biomed. Online 21 2010 440 443
11. N. Gleicher, and D.H. Barad Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR) Reprod. Biol. Endocrinol. 9 2011 67
12. N. Gleicher, and D.H. Barad Hype or hope? Ethical and practical considerations with clinical research in women with diminished ovarian reserve Reprod. BioMed. Online 25 2012 103 107
13. N. Gleicher, E. Ryan, A. Weghofer, S. Blanco-Mejia, and D.H. Barad Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study Reprod. Biol. Endocrinol. 7 2009 108
14. N. Gleicher, A. Weghofer, and D.H. Barad Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS) Reprod. Biol. Endocrinol. 8 2010 140
15. N. Gleicher, A. Weghofer, and D.H. Barad Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation Reprod. Biomed. Online 21 2010 360 365
16. D.J. Hendriks, E.R. Te Velde, C.W. Looman, L.F. Bancsi, and F.J. Broekmans Expected poor ovarian response in predicting cumulative pregnancy rates: a powerful tool Reprod. Biomed. Online 17 2008 727 736
17. K. Horie, K. Takakura, H. Fujiwara, H. Suginami, S. Liao, and T. Mori Immunohistochemical localization of androgen receptor in the human ovary throughout the menstrual cycle in relation to oestrogen and progesterone receptor expression Hum. Reprod. 7 1992 184 190
18. D. Isaacs, and D. Fitzgerald Seven alternatives to evidence based medicine BMJ 319 1999 1618
19. C.H. Kim, C.M. Howles, and H.A. Lee The effect of transdermal testosterone gel pretreatment on controlled ovarian stimulation and IVF outcome in low responders Fertil. Steril. 95 2011 679 683
20. E.R. Klinkert, F.J. Broekmans, C.W. Looman, and E.R. Te Velde A poor response in the first in vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles Fertil. Steril. 81 2004 1247 1253
21. A. Maheshwari, L. Stofberg, and S. Bhattacharya Effect of overweight and obesity on assisted reproductive technology - a systematic review Hum. Reprod. Update 13 2007 433 444
22. N. Massin, I. Cedrin-Durnerin, C. Coussieu, J. Galey-Fontaine, J.P. Wolf, and J.N. Hugues Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction technique - a prospective, randomized, double-blind study Hum. Reprod. 21 2006 1204 1211
23. M. Nielsen, I. Rasmussen, S. Kristensen, S. Christensen, K. Mollgård, E. Wreford Andersen, A. Byskov, and C. Yding Andersen In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA Mol. Hum. Reprod. 17 2011 63 70
24. J.F. Oudendijk, F. Yarde, M.J. Eijkemans, F.J. Broekmans, and S.L. Broer The poor responder in IVF: is the prognosis always poor? A systematic review Hum. Reprod. Update 18 2012 1 11
25. S. Rice, K. Ojha, S. Whitehead, and H. Mason Stage-specific expression of androgen receptor, follicle-stimulating hormone receptor, and anti-Mullerian hormone type II receptor in single, isolated, human preantral follicles: relevance to polycystic ovaries J. Clin. Endocrinol. Metab. 92 2007 1034 1040
26. H.N. Sallam, F. Ezzeldin, A.F. Agameya, A.F. Abdel-Rahman, and Y. El-Garem The definition of 'poor response': Bologna criteria Hum. Reprod. 27 2012 626 627 author reply 627-628
27. A. Sen, and S. Hammes Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function Mol. Endocrinol. 24 2010 1393 1403
28. M. Simoni, E. Nieschlag, and J. Gromoll Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction Hum. Reprod. Update 8 2002 413 421
29. S. Sudo, M. Kudo, S. Wada, O. Sato, A.J. Hsueh, and S. Fujimoto Genetic and functional analyses of polymorphisms in the human FSH receptor gene Mol. Hum. Reprod. 8 2002 893 899
30. S.K. Sunkara, and A. Coomarasamy Androgen pretreatment in poor responders undergoing controlled ovarian stimulation and in vitro fertilization treatment Fertil. Steril. 95 2011 e73 e74 author reply e75
31. T. Suzuki, H. Sasano, N. Kimura, M. Tamura, T. Fukaya, A. Yajima, and H. Nagura Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: relationship to expression of steroidogenic enzymes Hum. Reprod. 9 1994 1589 1595
32. Z. Veleva, I.Y. Jarvela, S. Nuojua-Huttunen, H. Martikainen, and J.S. Tapanainen An initial low response predicts poor outcome in in vitro fertilization/intracytoplasmic sperm injection despite improved ovarian response in consecutive cycles Fertil. Steril. 83 2005 1384 1390
33. J.T. Vreeburg, P.J. Schretlen, and M.J. Baum Specific, high-affinity binding of 17beta-estradiol in cytosols from several brain regions and pituitary of intact and castrated adult male rats Endocrinology 97 1975 969 977
34. K.A. Walters, C.M. Allan, and D.J. Handelsman Androgen actions and the ovary Biol. Reprod. 78 2008 380 389
35. S. Weil, K. Vendola, J. Zhou, and C. Bondy Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development J. Clin. Endocrinol. Metab. 84 1999 2951 2956
36. A. Wiser, O. Gonen, Y. Ghetler, T. Shavit, A. Berkovitz, and A. Shulman Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study Hum. Reprod. 25 2010 2496 2500
37. J.S. Younis Ovarian aging: latest thoughts on assessment and management Curr. Opin. Obstet. Gynecol. 23 2011 427 434
38. J.S. Younis The Bologna criteria for poor ovarian response; has the job been accomplished? Hum Reprod. 27 2012 1874 1875