Whole genome analyses reveal no pathogenetic single nucleotide or structural differences between monozygotic twins discordant for amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Volumn 16, Issue 5-6, 2015, Pages 385-392

  Meltz Steinberg, Karyn ^a   Nicholas, Thomas J ^a   Koboldt, Daniel C ^a   Yu, Bing ^b   Mardis, Elaine ^a   Pamphlett, Roger ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Amyotrophic lateral sclerosis; gene variant; genetics; genomics; monozygotic twin study; motor neuron disease; whole genome sequencing

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; EPIGENETICS; EWING SARCOMA BREAKPOINT REGION 1 GENE; FEMALE; GENE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC CONSERVATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME ANALYSIS; HEREDITY; HUMAN; LEUKOCYTE; MALE; MISSENSE MUTATION; MONOZYGOTIC TWINS; PATHOGENESIS; POPULATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; SYNAPTOTAGMIN 9 GENE; TWIN DISCORDANCE; COPY NUMBER VARIATION; GENE FREQUENCY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; GENOME; HETEROZYGOTE; MIDDLE AGED; TWINS;

CALMODULIN BINDING PROTEIN; EWSR1 PROTEIN, HUMAN; RNA BINDING PROTEIN; SYNAPTOTAGMIN; SYT9 PROTEIN, HUMAN;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; CALMODULIN-BINDING PROTEINS; DNA COPY NUMBER VARIATIONS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOME; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; RNA-BINDING PROTEINS; SYNAPTOTAGMINS; TWINS, MONOZYGOTIC;

EID: 84945117227     PISSN: 21678421     EISSN: 21679223     Source Type: Journal    
DOI: 10.3109/21678421.2015.1040029     Document Type: Article

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